Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Abstract

Objectives: To estimate the frequency of human papillomavirus (HPV) infection and the genotype distribution of HPV among women with a Pap smear showing atypical squamous cells of undetermined significance (ASC-US) attending the Program for the Detection and Control of Cervical Cancer in Bogotá, Colombia. Study Design: Cervical samples from 200 women with an ASC-US Pap smear were analyzed for the presence of HPV DNA and genotype distribution using a commercial molecular technique (Linear Array®; Roche Molecular Systems, USA). Results: HPV infection was found in 140 women (70%). High-risk HPV types were present in 46.4% of the samples; 16.4% showed a low-risk HPV type, and 37.1% showed both. Of the positive samples, 42.9% were infected with a single viral genotype, whereas 57.1% exhibited multiple HPV infections. The most common HPV genotypes were HPV 16, 53, and 52 with a prevalence of 26.4, 16.4, and 13.6%, respectively. Conclusion: The epidemiological characterization of HPV infections described in this study might guide actions for epidemiological surveillance to strengthen the program in Bogotá and to develop appropriate HPV vaccination programs.

<p>Prevalence and Genotype Distribution of High-Risk Human Papillomavirus Infection in Women with Abnormal Cervical Cytology: A Population-Based Study in Shanxi Province, China</p>

“…22 Castellsagué et al 23 reported that HPV16, HPV18, HPV31, HPV58, and HPV52 were the top-five HR-HPV types in both normal and abnormal cervical cytology, according to estimates from 193 countries. Hernan et al 24 found that HPV16, HPV53, HPV52, HPV58, and HPV59 were the top-five genotypes in women with abnormal cervical cytology from Bogotá, Colombia. Our findings indicated that the top-five HR-HPV genotypes were HPV16, HPV58, HPV52, HPV53, and HPV51 in women with abnormal cervical cytology in Shanxi, while HPV18 was in 12th position.…”

Characteristics of high-risk human papillomavirus infection in women with abnormal cervical cytology: a population-based study in Shanxi Province, China

“…X. Castellsagué et al [22] reported that HPV16, 18, 31, 58, 52 were the top five HR-HPV types in both women with normal and abnormal cervical cytology according to estimates from 193 countries. Hernan et al [23] found HPV16, 53, 52, 58 and 59 were the top five genotypes in women with abnormal cervical cytology from Bogota, Columbia. Our finding indicated that the top five HR-HPV genotypes were HPV16, 58, 52, 53 and 51 in women with abnormal cervical cytology in Shanxi Province, China, while HPV18 was in the 12th position.…”