Typhoid fever colitis with massive lower gastrointestinal bleeding

Salem, Yousif; Johnston, Keith A.; Salem, Amro

doi:10.18203/2349-2902.isj20190412

Cited by 1 publication

(2 citation statements)

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“…Studies reported that these complications are rarely encountered nowadays due to timely and effective antibiotic treatment. 8 , 9 Our patient presented with hematochezia after 2 weeks of systemic symptoms onset. Diagnosis of enteric fever is confirmed by isolation of Salmonella typhi from blood, bone marrow, stool, and urine specimens.…”

Section: Discussionmentioning

confidence: 81%

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Lower gastrointestinal bleeding as a complication of enteric fever: A case report

Abay,

Bhat,

Tadesse

2024

SAGE Open Medical Case Reports

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Enteric fever is a systemic bacterial infection caused by enteroinvasive, gram-negative bacilli, named Salmonella enterica serovar typhi and Salmonella enterica serovar paratyphi. It presents with hectic fever, headache, malaise, bowel habit changes, and abdominal pain. Diagnosis is usually confirmed by blood culture. Gastrointestinal complications of enteric fever include intestinal bleeding, bowel perforation, pancreatitis, and cholecystitis. We encountered a case of lower gastrointestinal bleeding (hematochezia) as a complication of enteric fever. A 35-year-old male patient presented to Aster CMI hospital, India, with an intermittent fever of 2-week duration associated with dry cough, loss of appetite, abdominal pain, and generalized body weakness. Four days after admission, he experienced three episodes of lower gastrointestinal bleeding. Upon physical examination, he was hemodynamically stable and had a high-grade fever, mild hepatomegaly, tipped splenomegaly, and lower abdominal tenderness. Blood culture grew Salmonella typhi. Abdominal ultrasound showed ileocolonic thickening with enlarged mesenteric lymph nodes. Abdominal computed tomography scan displayed enlarged mesenteric lymph nodes with surrounding fat strands. A colonoscopy revealed multiple shallow, punched-out, and punctate ileocolonic ulcerative lesions, with stigmata of active bleeding at caecal ulcers. Colonoscopy-guided biopsy suggested multifocal active colitis favoring infective etiology. Diagnosis of blood culture-confirmed enteric ulcer was made. He was treated with ceftriaxone 1 g iv twice daily for 10 days and rehydrated with intravenous fluids. Adrenaline injection was done at the site of bleeding ulcers, and hemostasis was secured. Other additional medications were antipyretics, anti-emetics, multivitamins, and proton pump inhibitors. He was fever-free on the third day of admission and discharged after 10 days of hospital stay. He was appointed to follow-up clinic after a week. He was completely healthy on the day of the first follow-up clinic visit and planned to resume his duties. Enteric fever remains a common public health problem in most developing countries. Early suspicion and prompt institution of appropriate antibiotics are crucial in the reduction of systemic and local complications of enteric fever. Since gastrointestinal complications of enteric fever are less often encountered in the antibiotic era, clinicians should be cognizant of an enteric ulcer as a cause of lower gastrointestinal bleeding.

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Section: Discussionmentioning

confidence: 81%

“…Life-threatening bleeding requires invasive measures including angiographic coil embolization, endoscopic therapy (adrenaline injection, thermal coagulation, or hemoclipping, alone or in combination), and surgical interventions (hemicolectomy or segmental resection). 6 , 9 , 12 , 14 , 15 …”

Section: Discussionmentioning

confidence: 99%