U-bent fiber optic plasmonic biosensor platform for ultrasensitive analyte detection

Ramakrishna, Bandaru; Divagar, M.; Khanna, S. N.; Danny, Christina Grace; Gupta, Shalini; Vani, Janakiraman; R, Sai V V

doi:10.1016/j.snb.2020.128463

Cited by 34 publications

(13 citation statements)

References 21 publications

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“…George et al [ 29 ] reported an immunobiosensor for the detection of chikungunya (an infectious disease) through the non-structural protein 3 (CHIKV-nsP3) biomarker, achieving a limit-of-detection (LOD) of 0.52 ng/mL. Bandaru et al [ 33 ] reported the production of a plasmonic U-bent fiber biosensor capable of detecting human immunoglobulin G with ultra-low LOD (∼7 aM). Manoharan et al [ 34 ] described a similar architecture for detecting bacterial endotoxins such as lipopolysaccharides with a LOD of 0.4 ng/mL.…”

Section: Cost-effective Optical Fiber Configurations For Biosensingmentioning

confidence: 99%

Cost-Effective Fiber Optic Solutions for Biosensing

et al. 2022

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In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.

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Section: Cost-effective Optical Fiber Configurations For Biosensingmentioning

confidence: 99%

Cost-Effective Fiber Optic Solutions for Biosensing

et al. 2022

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“… 134 More recently, a plasmonic fiberoptic absorbance biosensor (P-FAB), with a similar design, has been developed on the basis of this technique. 143 This low-cost, portable system provides huge potential for point-of-care testing, as proposed by Murugan et al 144 for COVID-19.…”

Section: Virus Sensor Technologiesmentioning

confidence: 99%

“…Using a low bandpass filter and photodetector, fluorescence intensity was measured when SARS-CoV nucleocapsid protein bound to its complementary antibody . More recently, a plasmonic fiberoptic absorbance biosensor (P-FAB), with a similar design, has been developed on the basis of this technique . This low-cost, portable system provides huge potential for point-of-care testing, as proposed by Murugan et al for COVID-19.…”

Section: Virus Sensor Technologiesmentioning

confidence: 99%

SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications

et al. 2021

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This review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals.

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“…Optical fiber-based LSPR sensors have been developed to detect different chemical and biomolecules such as enzymes, cortisol, cancer markers, and bacterial cells [ 78 , 79 , 90 , 91 , 92 , 93 ]. For example, cholesterol was detected by attaching cholesterol oxidase (ChOx) to AuNP-coated fiber via an adhesive layer of (3-mercaptopropyl) trimethoxysilane.…”

Section: Current Lspr Biosensors For the Detection Of Chemical And Biomoleculesmentioning

confidence: 99%

Biosensing Applications Using Nanostructure-Based Localized Surface Plasmon Resonance Sensors

Kim

Park

Jung

et al. 2021

Sensors

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Localized surface plasmon resonance (LSPR)-based biosensors have recently garnered increasing attention due to their potential to allow label-free, portable, low-cost, and real-time monitoring of diverse analytes. Recent developments in this technology have focused on biochemical markers in clinical and environmental settings coupled with advances in nanostructure technology. Therefore, this review focuses on the recent advances in LSPR-based biosensor technology for the detection of diverse chemicals and biomolecules. Moreover, we also provide recent examples of sensing strategies based on diverse nanostructure platforms, in addition to their advantages and limitations. Finally, this review discusses potential strategies for the development of biosensors with enhanced sensing performance.

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U-bent fiber optic plasmonic biosensor platform for ultrasensitive analyte detection

Cited by 34 publications

References 21 publications

Cost-Effective Fiber Optic Solutions for Biosensing

Cost-Effective Fiber Optic Solutions for Biosensing

SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications

Biosensing Applications Using Nanostructure-Based Localized Surface Plasmon Resonance Sensors

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