u-Plasminogen Activator

Ellis, Vincent

doi:10.1016/b978-0-12-382219-2.00645-1

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…The role of the plasminogen cascade enzymes in the epidermis has been discussed for 35 years . However, it was not until recently that their relevance in the SC was established .…”

Section: Discussionmentioning

confidence: 99%

“…Besides kallikreins (KLKs), other serine proteases, and especially members of the trypsin family such as urokinase (uPA) and plasmin together with their zymogens, have started to receive more attention . Activation of pro‐uPA, the zymogen of uPA, generates catalytically active high molecular weight (HMW)‐uPA and a low molecular weight (LMW)‐uPA . A number of serine and cysteine proteases can activate pro‐uPA such as plasmin, matriptase, tryptase, and the various trypsin‐like KLKs and the cathepsins B and L .…”

Section: Introductionmentioning

confidence: 99%

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The effects of benzylsulfonyl‐D‐Ser‐homoPhe‐(4‐amidino‐benzylamide), a dual plasmin and urokinase inhibitor, on facial skin barrier function in subjects with sensitive skin

Voegeli

Wikstroem

Campiche

et al. 2016

Intern J of Cosmetic Sci

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“…The role of the plasminogen cascade enzymes in the epidermis has been discussed for 35 years . However, it was not until recently that their relevance in the SC was established .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of benzylsulfonyl‐D‐Ser‐homoPhe‐(4‐amidino‐benzylamide), a dual plasmin and urokinase inhibitor, on facial skin barrier function in subjects with sensitive skin

Voegeli

Wikstroem

Campiche

et al. 2016

Intern J of Cosmetic Sci

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The Role of Stromal Proteolytic Systems in Cancer Progression (Review)

Кугаевская

Timoshenko

et al. 2019

Obŝaâ reanimatologiâ

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Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available for prevention of critical illness accompanying this pathological condition.Nowadays, proteolytic systems of tumor microenvironment (ТМЕ) are regarded as key regulators of a tumor progression including tumor growth, invasion and metastazing. The review discusses ТМЕ structure and role in cancer progression.Recent data decipher the role of proteolytic systems in the interaction stromal cells with tumor cells in different types of cancer in humans. The most known proteolytic systems contributed to cancer progression are matrix metalloproteinase system (MMP), urokinase-type plasminogen activator system (uPA-system), various cathepsins, granzymes, and elastase. Inhibition of extracellular proteolysis in the course of an oncological process is considered an effective approach to cancer therapy.

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The urokinase-type plasminogen activator system and its role in tumor progression

Kugaevskaya

Timoshenko

et al. 2018

BIOMED KHIM

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In the multistage process of carcinogenesis, the key link in the growth and progression of the tumor is the invasion of malignant cells into normal tissue and their distribution and the degree of destruction of tissues. The most important role in the development of these processes is played by the system of urokinase-type plasminogen activator (uPA system), which consists of several components: serine proteinase – uPA, its receptor – uPAR and its two endogenous inhibitors – PAI-1 and PAI-2. The components of the uPA system are expressed by cancer cells to a greater extent than normal tissue cells. uPA converts plasminogen into broad spectrum, polyfunctional protease plasmin, which, in addition to the regulation of fibrinolysis, can hydrolyze a number of components of the connective tissue matrix (СTM), as well as activate the zymogens of secreted matrix metalloproteinases (MMР) – pro-MMР. MMРs together can hydrolyze all the main components of the СTM, and thus play a key role in the development of invasive processes, as well as to perform regulatory functions by activating and releasing from STM a number of biologically active molecules that are involved in the regulation of the main processes of carcinogenesis. The uPA system promotes tumor progression not only through the proteolytic cascade, but also through uPAR, PAI-1 and PAI-2, which are involved in both the regulation of uPA/uPAR activity and are involved in proliferation, apoptosis, chemotaxis, adhesion, migration and activation of epithelial-mesenchymal transition pathways. All of the above processes are aimed at regulating invasion, metastasis and angiogenesis. The components of the uPA system are used as prognostic and diagnostic markers of many cancers, as well as serve as targets for anticancer therapy.

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u-Plasminogen Activator

Cited by 3 publications

References 68 publications

The effects of benzylsulfonyl‐D‐Ser‐homoPhe‐(4‐amidino‐benzylamide), a dual plasmin and urokinase inhibitor, on facial skin barrier function in subjects with sensitive skin

The effects of benzylsulfonyl‐D‐Ser‐homoPhe‐(4‐amidino‐benzylamide), a dual plasmin and urokinase inhibitor, on facial skin barrier function in subjects with sensitive skin

The Role of Stromal Proteolytic Systems in Cancer Progression (Review)

The urokinase-type plasminogen activator system and its role in tumor progression

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