Über den Nachweis komplementbindender Auto-Antikörper bei Nieren- und Lebererkrankungen

Vorlaender, K. O.

doi:10.1007/bf02045954

Cited by 46 publications

(6 citation statements)

References 14 publications

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“…During the last years, "autoimmunization" has been demonstrated to occur in an increasing number of diseases, characterized by symptoms similar to those described above as typical for ulcerative colitis. Circulating antibodies against constituents of human tissue have been detected in disorders of the thyroid (16)(17)(18)(19), lupus erythematosus disseminatus (20)(21)(22)(23), Addison's disease (24), lupoid hepatitis (25,26), acute nephritis (27,28), the nephrotic syndrome (27), and in other diseases. In some of these disorders it has been possible to determine the chemical nature of the antigen capable of reacting with such antibodies.…”

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confidence: 99%

Autoantibodies in Human Ulcerative Colitis

Broberger

Perlmann

1959

The Journal of Experimental Medicine

397

108

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Sera from 30 children, suffering from ulcerative colitis, were examined for the presence of antibodies capable of reacting with antigens of normal human tissue. It was possible to demonstrate that most of the sera contained a precipitating and hemagglutinating factor, reacting with a constituent of human colonic tissue. This constituent was obtained, within 1 hour after death, from colonic tissue of newborn babies who had died without feeding. It could also be prepared from fetal tissue. The antigen can be extracted with phenol-water at 65°C. and seems to be a polysaccharide. The precipitating factor in the sera of the patients behaves electrophoretically as a γ-globulin. Phenol-water extracts from liver and from kidney also reacted positively with the sera from certain patients. There are indications which suggest that the antigen obtained from these tissues is identical with that from colon. Sera from 38 healthy children did not give any reactions with the extracts used. In additional controls, the sera of 32 children with various diseases, all of suspected autoimmune origin, were also tested. A few of these reacted positively with the phenol-water extracts from the organs mentioned above. Most likely, the antigen reacting in these cases is different from that reacting with the antibodies in the sera from patients with ulcerative colitis. The possible role of the antibodies in the pathogenesis of ulcerative colitis and the mechanism of their formation are discussed.

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confidence: 99%

Autoantibodies in Human Ulcerative Colitis

Broberger

Perlmann

1959

The Journal of Experimental Medicine

397

108

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“…Antibodies against liver tissue were demonstrated as early as 1908 by Fiessinger (13) in serum from a number of patients with liver cirrhosis, and the demonstration of autoantibodies in liver cirrhosis has recently been described by Dausset (8). Circulating antibodies against liver tissue have also been demonstrated in hepatitis (12,39,6). The demonstration of circulating antibodies is, however, no direct evidence of autoimmunization as a cause of the liver disease.…”

Section: Discussionmentioning

confidence: 99%

Liver Cirrhosis in Patients with a Lupus Erythematosus‐like Syndrome

Krook

1961

Journal of Internal Medicine

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“…This hypothesis would not explain the onset of nephritis without a latent period. In human glomerulonephritis an antibody to human kidney has been found (Bialcstock, 1951 andVorlaender, 1952;Pfeiffer, SchofHing and Bnich, 1953). Sarre et al (1954) found no such antibody in the serum of rabbits with Masugi nephritis.…”

Section: Discussionmentioning

confidence: 99%