über die Beziehungen des Gleichgewichtes Cholesterin und Cholesterinester im Blut und Serum zur Leberfunktion

Thannhauser, S. J.; Schaber, Hans

doi:10.1007/bf01736611

Cited by 79 publications

(13 citation statements)

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“…In 1926 Thannhauser and Schaber 27 reported an association between low cholesterol and disease. Subsequently, total cholesterol (TC), low-density lipoprotein (LDL), and highdensity lipoprotein (HDL) have been shown to be substantially reduced in patients with many disorders including infections, burns and cancer [28][29][30] .…”

Section: Mechanisms Of Cholesterol Defi Ciencymentioning

confidence: 99%

Hypocholesterolemia in Clinically Serious Conditions - Review

Vyroubal¹,

Chiarla²,

Giovannini³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background:Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids and other components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demanding process. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown. During stressful situations a signifi cant hypocholesterolaemia may be found. Hypocholesterolemia has been known for a number of years to be a signifi cant prognostic indicator of increased morbidity and mortality connected with a whole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemia during the intensive care. . Methods and Results:We examined studies that are engaged in problems of hypocholesterolemia in critically ill. Very low levels of total as well as LDL cholesterol are most frequently found in serious polytrauma, after extensive surgery, in serious infections, in protracted hypovolemic shock. It is still not clear whether hypocholesterolemia refl ects only a serious metabolic disorder, which results from a life-threatening condition, or whether it has an active role in evolution and outcome.Conclusions: Hypocholesterolemia is commonly observed in critically ill patients. Nevertheless, it is not known whether it is a secondary manifestation of disease, or whether it actively contributes to deterioration of the disease. Although the contribution of hypocholesterolemia to mortality is modest compared with known risk factors such as increased severity of illness and the development of nosocomial infection, low serum lipid concentrations represent a potential therapeutic target in sepsis.

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Section: Mechanisms Of Cholesterol Defi Ciencymentioning

confidence: 99%

Hypocholesterolemia in Clinically Serious Conditions - Review

Vyroubal¹,

Chiarla²,

Giovannini³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…By ultracentrifugal analysis, Havel, Eder and Bragdon (19) In the present investigation, a chromatographic technique for the estimation of the main individual phospholipids of serum (21,22) was employed in order to characterize further the serum lipid abnormalities of patients with liver disease. The lipids were analyzed in this way in the whole serum of 12 patients with parenchymatous or obstructive jaundice, 3 patients with cirrhosis without jaundice, and 3 patients with bile fistula. In 10 of these patients, in addition, the lipids of the ultracentrifugally separated serum fractions D < 1.019, < 1.063, and > 1.063 were analyzed in the same manner.…”

mentioning

confidence: 99%

The Lipid Composition of Serum in Patients With Liver Disease*

Phillips¹

1960

J. Clin. Invest.

106

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“…Pierce and Gofman (6) examined the sera of thirty-two patients with cirrhosis and found levels of the Sf 10-20 class slightly higher than normal. They also studied forty-eight cases of acute hepatitis (7) and found elevations of the Sf 0-100 components with the largest increase in the Sf [12][13][14][15][16][17][18][19][20] class. The increased concentrations correlated most closely with the presence of jaundice and tended to decrease when the jaundice subsided.…”

mentioning

confidence: 99%

Protein-Lipid Relationships in Human Plasma: In Biliary Cirrhosis, Obstructive Jaundice, and Acute Hepatitis 1

Eder¹,

Russ²,

Pritchett³

et al. 1955

J. Clin. Invest.

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In 1862, Austin Flint (1) found that cholesterol accumulated in the blood in obstructive jaundice.Fifty years later Widal, Weill, and Laudat (2) pointed out that the hypercholesterolemia of obstructive jaundice is due in large measure to increase in serum free cholesterol in contradistinction to that of nephrosis, where both free and esterified cholesterol are greater than normal.More recently (3-5) it has been shown that plasma phospholipid increases even more than cholesterol, so that the ratio of total cholesterol to phospholipid is appreciably less than normal.The serum lipoproteins have also been measured in patients with liver disease. Pierce and Gofman (6) examined the sera of thirty-two patients with cirrhosis and found levels of the Sf 10-20 class slightly higher than normal. They also studied forty-eight cases of acute hepatitis (7) and found elevations of the Sf 0-100 components with the largest increase in the Sf [12][13][14][15][16][17][18][19][20] class. The increased concentrations correlated most closely with the presence of jaundice and tended to decrease when the jaundice subsided. McGinley, Jones, and Gofman (8) found a huge increase in the Sf 6 and Sf 8 groups, with varying increase in Sf 10-17 in five cases of biliary cirrhosis. By starch zone electrophoresis, Kunkel and Slater (9) observed that in biliary cirrhosis there was a high peak consisting predominantly of phospholipid which had the same relative mobility as normal beta lipoproteins. The concentration of alpha lipoproteins was extremely low.

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über die Beziehungen des Gleichgewichtes Cholesterin und Cholesterinester im Blut und Serum zur Leberfunktion

Cited by 79 publications

References 0 publications

Hypocholesterolemia in Clinically Serious Conditions - Review

Hypocholesterolemia in Clinically Serious Conditions - Review

The Lipid Composition of Serum in Patients With Liver Disease*

Protein-Lipid Relationships in Human Plasma: In Biliary Cirrhosis, Obstructive Jaundice, and Acute Hepatitis 1

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