Über die Hemmwirkung einiger Amine auf das Wachstum von Tuberkelbazillen

Wagner‐Jauregg, Th.; Wagner, W. H.; Vonderbank, Hermann

doi:10.1007/bf00588670

Cited by 5 publications

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“…The proposal that immune dysfunction, or more specifically non-resolving low-level inflammation, may be relevant in depression and a target for treatment was first proposed in the early 1900s with vaccine therapy and the potential for typus to improve symptoms in patients residing in German asylums 64 . Associative evidence is strong, with increased levels of inflammatory cytokines including interleukin (IL) 6, TNFa and C-reactive protein (CRP) consistently reported to be higher in patients with depression compared to controls.…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

Novel and emerging treatments for major depression

et al. 2023

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Section: Anti-inflammatory Agentsmentioning

confidence: 99%

Novel and emerging treatments for major depression

et al. 2023

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Synthesis and some reactions of naphth[1,2‐d]oxazole‐5‐sulfonic acids

Osman

Youssef

Atta

1982

Journal of Heterocyclic Chem

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Naphth[1,2‐d]oxazole‐5‐sulfonic acid (1) has been prepared by the fusion of 4‐amino‐3‐hydroxynaphthalene‐1‐sulfonic acid with formamide. Interaction of 1 with a number of arenesulfonyl chlorides, aryloxyacetyl chlorides, 1‐naphthyloxyacetyl chloride, and chloroacetyl chloride gave 2‐(arylsulfonyl)‐, 2‐(aryloxyacetyl)‐, 2‐(1‐naphthyloxyacetyl)‐ and 2‐(chloroacetyl)naphth[1,2‐d]oxaxole‐5‐sulfonic acids (2, 3, 4 and 5), respectively. The corresponding sulfonyl chloride of 2 was condensed with amines giving the expected 2‐(arylsulfonyl)‐naphth[1,2‐d]oxazole‐5‐sulfonamides (6). Interaction of 5 with hydrazine gave 2‐hydrazinoacetyl and disubstituted hydrazine derivatives 7 and 8. Condensation of 7 with aromatic aldehydes yielded substituted hydrazonoacetyl derivatives 9. Two moles of 5 react with one mole of hydroquinone in dry acetone in the presence of anhydrous potassium carbonate and potassium iodide gave 1,4‐bis[5‐sulfonaphth[1,2‐d]oxazol‐2‐ylcarbonyl‐methoxy]benzene (10).

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Umlagerungsprodukte von Phenol‐ und Salicylsäure‐estern und deren tuberkulocide Eigenschaften

Vogelsang

Wagner‐Jauregg

1950

Justus Liebigs Ann. Chem.

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V o g e 1 s a n q i d Wagner -Jaw r P g g -Prop yl-3-meth yl-cholanthren (VI I I)Eine LBsung von 86,l mg 0x0-methyl-tetrahydro-cholanthren (XVI) v o m S c h m p . 181" in 5 ccm abs. Benzol wurde auf einmal zu einer GrignardLosung, die aus 57 mg M a g n e s i u m und 0,4 ccm frisch destilliertem n-Propyljodid in 5 ccm abs. Ather hergestellt worden war, hinzugegeben. Die Reaktionsmischung wurdc 1 Stundc auf dem Wasserbad am RiickfluIJ zum Siedeii erhitzt, dann mit Salzsaure zersetzt und ausgeathert. Die Lthe!:ische Lasung wurde neutral gewaschen und getrocknet. Der Riickstand der Ather-Losung (91 mg hellgelbes 81) wurde gut getrocknet und ohne weitere Reinigung mit 27 mg 22proc. P l a t i n -K o h l e O ) unter CO, auf 260" erhitzt.

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Über die Hemmwirkung einiger Amine auf das Wachstum von Tuberkelbazillen

Cited by 5 publications

References 0 publications

Novel and emerging treatments for major depression

Novel and emerging treatments for major depression

Synthesis and some reactions of naphth[1,2‐d]oxazole‐5‐sulfonic acids

Umlagerungsprodukte von Phenol‐ und Salicylsäure‐estern und deren tuberkulocide Eigenschaften

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