Über eine pulmonale Infektion durch Mycobacterium malmoense

Abstract

Nicht-tuberkulöse Mykobakterien gewinnen als Infektionserreger beim Menschen zunehmend an Bedeutung.Neben Mycobacterium (M.) avium-intracellulare ist hier vor allem M. malmoense zu nennen. AbstractM. malmoense could be cultivated in sputum samples of a 49-year-old patient with destructive pulmonary disease. The conventional antituberculous therapy (started because initially a presumptive diagnosis of tuberculosis was established) was altered to ethambutol, rifabutin, clarithromycin and ciprofloxacin, followed by a long-time therapy with azithromycin or clarithromycin. But till now it was not possible to eradicate the mycobacteria from the respiratory tract (insufficient compliance, interruptions of the therapy due to side effects, excessive smoking). Infections due to M. malmoense are rare events. Many patients have disposing underlying diseases. In most cases it is a pulmonary infection. The most frequent used antibiotics are rifampicin (or rifabutin), ethambutol and clarithromycin.

The First Surgical Treatment Case of Pulmonary Mycobacterium malmoense Infection in Japan

“…In addition, some reports stated that pulmonary M. malmoense infection was mainly complicated by chronic obstructive lung disease, such as pneumoconiosis, chronic airway infection, or pulmonary emphysema (7,8,9). Moreover, it was reported that M. malmoense infection was usually observed among HIV-negative people (2,10 (2,10,11,(13)(14)(15) …”