Über einige Inhaltsstoffe der bakteriellen Tumoren vonBryophyllum daigremontianum (Hamet et Perr.) Berg

Karsten, Uwe; Müller‐Stoll, Wolfgang R.

doi:10.1007/bf02103164

Cited by 2 publications

(6 citation statements)

References 20 publications

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“…Peaks A ( t R = 9.9 min; λ max = 271 nm), B ( t R = 10.2 min; λ max = 271 nm) and C ( t R = 15.4 min; λ max = 281 nm) were attributed to benzoic acid derivatives, while peak E ( t R = 19.4 min; λ max = 309 nm) to a cinnamic acid derivative. Peaks D ( t R = 16.5 min; λ max = 290 nm) and F ( t R = 19.9 min; λ max = 296 nm) were assigned to bufadienolides …”

Section: Resultsmentioning

confidence: 99%

“…[18 -23] However, the only flavonoid reported for K. daigremontiana is kaempferol 3-p-coumaroylarabinoside, named bryophylloside. [23] [24] The presence of bioactive flavonoids in other Kalanchoe species was reported in some studies. [15] [25 -27] The present study aimed to investigate the flavonoid content of K. daigremontiana and to assess its antiherpetic potential using acyclovir-sensitive strains of HSV-1 and HSV-2 in in vitro replication assays.…”

Section: Introductionmentioning

confidence: 97%

“…However, the only flavonoid reported for K . daigremontiana is kaempferol 3‐ p ‐coumaroylarabinoside, named bryophylloside . The presence of bioactive flavonoids in other Kalanchoe species was reported in some studies…”

Section: Introductionmentioning

confidence: 99%

“…Several bufadienolides and phenolic substances were isolated from this plant . However, the only flavonoid reported for K .…”

Section: Introductionmentioning

confidence: 99%

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Anti‐HSV‐1 and HSV‐2 Flavonoids and a New Kaempferol Triglycoside from the Medicinal Plant Kalanchoe daigremontiana

Ürményi

Saraiva

Casanova

et al. 2016

Chemistry & Biodiversity

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Kalanchoe daigremontiana (Crassulaceae) is a medicinal plant native to Madagascar. The aim of this study was to investigate the flavonoid content of an aqueous leaf extract from K. daigremontiana (Kd), and assess its antiherpetic potential. The major flavonoid, kaempferol 3-O-β-d-xylopyranosyl-(1 → 2)-α-l-rhamnopyranoside (1), was isolated from the AcOEt fraction (Kd-AC). The BuOH-soluble fraction afforded quercetin 3-O-β-d-xylopyranosyl-(1 → 2)-α-l-rhamnopyranoside (2) and the new kaempferol 3-O-β-d-xylopyranosyl-(1 → 2)-α-l-rhamnopyranoside-7-O-β-d-glucopyranoside (3), named daigremontrioside. The crude extract, Kd-AC fraction, flavonoids 1 and 2 were evaluated using acyclovir-sensitive strains of HSV-1 and HSV-2. Kd-AC was highly active against HSV-1 (EC = 0.97 μg/ml, SI > 206.1) and HSV-2 (EC = 0.72 μg/ml, SI > 277.7). Flavonoids 1 and 2 showed anti-HSV-1 (EC = 7.4 μg/ml; SI > 27 and EC = 5.8 μg/ml; SI > 8.6, respectively) and anti-HSV-2 (EC = 9.0 μg/ml; SI > 22.2 and EC = 36.2 μg/ml; SI > 5.5, respectively) activities, suggesting the contribution of additional substances to the antiviral activity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

“…Several bufadienolides and phenolic substances were isolated from this plant . However, the only flavonoid reported for K .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti‐HSV‐1 and HSV‐2 Flavonoids and a New Kaempferol Triglycoside from the Medicinal Plant Kalanchoe daigremontiana

Ürményi

Saraiva

Casanova

et al. 2016

Chemistry & Biodiversity

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“…The different activities of K. daigremontiana depend on its phytochemical composition, and its analysis has shown that flavonoids, phenolic acids, and bufadienolides are the main metabolites [8,11,[13][14][15]. To date, only 4 flavonoid compounds of K. daigremontiana have been reported in the literature [8,16].…”

Section: Identification Of Flavonoids and Bufadienolides And Cytotoximentioning

confidence: 99%

Identification of Flavonoids and Bufadienolides and Cytotoxic Effects of Kalanchoe daigremontiana Extracts on Human Cancer Cell Lines

et al. 2020

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Kalanchoe species are well-known medicinal plants used in traditional medicine as anti-inflammatory and analgesic remedies. Recently, it has been reported that Kalanchoe plants have cytotoxic properties; however, data on traditional use of these plants in tumor treatment are extremely limited. Kalanchoe daigremontiana is one of the most popular species cultivated in Europe, and it is used, among other things, as a remedy in treating skin injuries and wounds. Studies on the biological activity of this species are scarce, and there is a lack of data on the cytotoxic activity of K. daigremontiana extracts on epithelial cancer cells in the literature. In our present study, we analyzed the phytochemical composition of K. daigremontiana ethanol extract and fractions–water and dichloromethane–by the HPLC-DAD-ESI-MS method and estimated cytotoxic activity of the extracts on human adenocarcinoma (HeLa), ovarian (SKOV-3), breast (MCF-7), and melanoma (A375) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, real-time cell analyzer (RTCA), and flow cytometry. We identified 6 bufadienolide compounds and 19 flavonoids, mostly kaempferol, quercetin, isorhamnetin, and myricetin glycosides, of which only 3 flavonoids have been identified in K. daigremontiana to date. Other flavonoids that were characterized in our study have not yet been found in this plant. The ethanol extract and water fraction of K. daigremontiana did not show significant cytotoxic activity on the tested cell lines. In contrast, the dichloromethane fraction showed the strongest activity against all cell lines with IC50 values of ≤ 10 µg/mL. The results indicated that this activity is mainly due to the presence of bersaldegenin-1,3,5-orthoacetate.

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Über einige Inhaltsstoffe der bakteriellen Tumoren vonBryophyllum daigremontianum (Hamet et Perr.) Berg

Cited by 2 publications

References 20 publications

Anti‐HSV‐1 and HSV‐2 Flavonoids and a New Kaempferol Triglycoside from the Medicinal Plant Kalanchoe daigremontiana

Anti‐HSV‐1 and HSV‐2 Flavonoids and a New Kaempferol Triglycoside from the Medicinal Plant Kalanchoe daigremontiana

Identification of Flavonoids and Bufadienolides and Cytotoxic Effects of Kalanchoe daigremontiana Extracts on Human Cancer Cell Lines

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