Über Hemmwirkungen des Serums von Kranken mit hepatorenalem Syndrom und mit chronischer Urämie auf Sauerstoffverbrauch und Kohlenhydratstoffwechsel von Nieren- und Hirngewebe der Ratte

Energy Metabolism in Acute Uremic Rats

“…The toxic effects of uremic serum on substrate utili zation and oxidative phosphorylation in various tissues obtained from normal rats were, however, practically simi lar, irrespective of the fact whether the serum was taken from humans in acute or chronic state of uremia [5,6,10,13]. This difference between in vitro experiments and ob servations in intact organisms is very striking.…”

“…Another possibility is the in capability of isolated tissue to react as the whole organism would do. It may be remarked that not all sera from acute or chronic uremic humans depress the VO2 of isolated tissues [6,13].…”

“…Lowered rates of respiration, substrate utilization, gluconeogenesis and oxidative phosphorylation have been observed when tissue slices or isolated mitochondria were incubated in uremic serum [5,6,10,13]. However, not much work has been re ported on whole organisms under uremic state, except for Adelman and Holliday [1] who only recently reported on energy consumption in chronic uremic rats.…”

Carbohydrate Metabolism of Salivary Glands of Acutely Uremic Rats

“…A lowered lactate production subse quent to ischemic exercise of the forearm muscle in chronic renal insufficiency has been reported by Nakao et al [25] and Westervelt [26], whereas Quintanilla et al [27] de scribed decreased lactate generation by liver slices from uremic rats. Inhibited phosphofructokinase activity of kid ney slices in the presence of uremic serum has been ob served by Renner and Heintz [9,28]. Corresponding to these results, a decreased glucose utilization was found in kidney slices bathed in uremic serum [8].…”

“…According to these authors metabolic acidosis facilitates the increased gluconeogenetic ability of the kid neys. Glucose utilization is inhibited in brain slices bathed in uremic serum [8,9]. Notable results have been obtained by DeFerrari et al [10] demonstrating that the uremic brain does not utilize amino acids.…”