Ubiquitous convalescent plasma: An artificial universal plasma for COVID-19 patients

Bardsiri, Mahla Sattarzadeh; Kouhbananinejad, Seyedeh Mehrnaz; Vahidi, Reza; Soleimany, Saeed; Moghadari, Masoud; Derakhshani, Ali; Kashani, Bahareh; Farsinejad, Alireza

doi:10.1016/j.transci.2021.103188

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…It is difficult to establish these procedures in small individual blood banks as they require either specialized or large-scale equipment. The principle of adsorbing the isoagglutinins onto structures expressing the cognate antigens can also be applied by adding red cells from red cell concentrates [ 17 ]. This also allows for the removal of the formed immune complexes.…”

Section: Introductionmentioning

confidence: 99%

Plasma Isoagglutinin Depletion for Blood Group Independent Plasma Transfusion

Raster¹,

Jacob²,

Greinacher³

et al. 2022

Transfus Med Hemother

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Background: Plasma transfusion is one of the basic treatments in patients with major blood loss. The anti-A and anti-B antibodies contained in the plasma demand ABO blood group compatibility. This is limiting the use of plasma in emergency situations and can cause a shortage in the supply of plasma of certain blood groups. We developed a method for anti-A and anti-B depletion by adsorbing plasma isoagglutinins using red blood cells. Materials and Methods: Three units of fresh frozen plasma were thawed after quarantine storage, pooled, and an aliquot of red cell concentrate was added. After 2 h of incubation at room temperature antibody-red-cell complexes were removed by centrifugation, the isoagglutinin-depleted plasma was split into three units and deep frozen. Isoagglutinin titers, free hemoglobin, residual red cells, clotting factor activity, and sterility of plasma units were determined after isoagglutinin depletion and a double freeze-thawing procedure. Results: Anti-B titers in group A plasma were reduced from values of 1:64 to 1:1 or lower, anti-A titers in group B plasma decreased from values of 1:128 to at least 1:16. Postprocedure clotting factor activities were preserved with 88.0 ± 7.3% (factor V), 106.9 ± 11.4% (factor VIII), and 84.0 ± 7.5% (factor XI) fulfilling the quality control requirements. No residual red cells were found, but free hemoglobin slightly increased to 53.7 ± 5.2 μmol/L. All units were sterile. Discussion: We described a method for the production of anti-A- and anti-B-depleted plasma in a closed system that uses standard equipment. The resulting isoagglutinin-depleted plasma may allow for blood group independent plasma transfusion.

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Section: Introductionmentioning

confidence: 99%

Plasma Isoagglutinin Depletion for Blood Group Independent Plasma Transfusion

Raster¹,

Jacob²,

Greinacher³

et al. 2022

Transfus Med Hemother

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Changes in Psycho-Physiological Indicators After Training With the Use of Neuro-Biofeedback in People Who Had Covid-19

Zonov¹,

Nasyrova²,

Leontiev

2022

Acta med. Eurasica

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COVID-19 is an acute respiratory infection caused by SARS-CoV-2 coronavirus. The most common complications of this disease are viral pneumonia, acute respiratory failure and thromboembolism, up to 20% of patients suffer from long–term symptoms. The purpose of this study was to study the possibility of using neuro-biofeedback method in neuro-correction of patients who had suffered from COVID-19 disease with emotional disorders. The study involved 40 people (27 women and 13 men) who had suffered from COVID-19, experiencing emotional disorders and in need of rehabilitation, of whom 24 individuals made up the main group and 16 individuals – the control group. The age of the participants ranged from 25 to 73 years, the mean age was 42.25±2.59 years. Prior to the beginning and at the end of the study, both groups underwent tests: the "Depression Questionnaire", the State-Trait Anxiety Inventory, determination by the PSM-25 stress scale. The equipment "Neuro V" (Zelenograd, Russia) was used for neuro-biofeedback training. The neuro-feedback technology "Neuro V" makes it possible to use electroencephalography parameters for self-regulation. Stimulation of the alpha rhythm in the frequency range 8-14 Hz helped to change the psychoemotional state of the subjects. The changes were confirmed by valid diagnostic tests "Spielberger–Khanin Anxiety Scale", "Depression Questionnaire", indicators on PSM-25 stress scale, as well as a "subjective" decrease in the severity of the asthenic syndrome. The technique that we propose gave the opportunity to increase not only the indices of alpha rhythm power in the electroencephalography, but the subjective assessment of health as well.

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Ubiquitous convalescent plasma: An artificial universal plasma for COVID-19 patients

Cited by 2 publications

References 25 publications

Plasma Isoagglutinin Depletion for Blood Group Independent Plasma Transfusion

Plasma Isoagglutinin Depletion for Blood Group Independent Plasma Transfusion

Changes in Psycho-Physiological Indicators After Training With the Use of Neuro-Biofeedback in People Who Had Covid-19

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