Ugi products containing boronate esters

Appoh, Francis E.; Manning, Marcy J.; Gullon, Teri J.; Hansen, Margaret A.; Bevans, Emily C.; Hogan, Krista D. M.; Turner, Courtney S.; Vogels, Christopher M.; Decken, Andreas; Westcott, Stephen A.

doi:10.2478/s11532-008-0030-7

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…However, these studies mainly focused on improving the conditions for constructing molecules containing the elements carbon, hydrogen, oxygen, nitrogen, halogens, and sulfur. Reports on utilizing an MCR as a platform to generate boron-containing analogs are very limited, and those that have been published often demonstrate the requirement for a prolonged reaction time or excessive purification procedures [31]. Herein, we report the use of the Passerini reaction for the efficient synthesis of boron-containing α-acyloxyamides.…”

Section: Introductionmentioning

confidence: 99%

Efficient Synthesis of Boron-Containing α-Acyloxyamide Analogs via Microwave Irradiation

et al. 2013

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Abstract:In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%