UHPLC Q-Exactive Orbitrap MS based metabolomics and biological activities of Camellia fascicularis from different geographical regions

Shi, Zhijiao; Tang, Junrong; Xiang, Jianying; Deng, Jia; Kan, Huan; Shi, Zhengjun; Zhao, Ping; Zhang, Yingjun; Liu, Yun

doi:10.1016/j.indcrop.2024.118432

Industrial Crops and Products

2024

DOI: 10.1016/j.indcrop.2024.118432

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UHPLC Q-Exactive Orbitrap MS based metabolomics and biological activities of Camellia fascicularis from different geographical regions

Zhijiao Shi,

Junrong Tang,

Jianying Xiang

et al.

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2024

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Cited by 2 publications

References 49 publications

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The uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition

Yilmaz,

Cakir,

Zengin

et al. 2024

Food Bioscience

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The uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition

Yilmaz,

Cakir,

Zengin

et al. 2024

Food Bioscience

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Bioactivity-Guided Isolation of Secondary Metabolites from Camellia fascicularis: Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking

Tang,

Li,

et al. 2024

Foods

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Camellia fascicularis is a valuable ornamental, edible, and medicinal plant with promising prospects for bioactivity development. We screened the bioactivity of eight fractions (Fr. A−I) obtained from the ethyl acetate phase of C. fascicularis via silica gel column chromatography. The results indicated that the anti-inflammatory, antioxidative, and antimicrobial active components were mainly found in Fr. B*, E, A, and H; Fr. A–G; and Fr. D–I, respectively. Bioactivity-guided isolation identified 18 secondary metabolites. Compounds 1, 3–5, 7, and 15–18 were isolated from the genus Camellia for the first time in this study, whereas the other compounds were also isolated from this plant for the first time. The structures of these compounds were elucidated through comprehensive spectroscopic techniques. Compounds 1, 9−11, 28, 30, and 31 demonstrated antioxidative activities comparable to those of ascorbic acid, whereas the remaining compounds exhibited diminished antioxidative activity. In terms of antimicrobial activity, compounds 7, 18, 22, and 27 exerted inhibitory potency against Pseudomonas aeruginosa, similar to tetracycline (MIC: 125 µg/mL). Other compounds showed moderate to weak inhibitory effects against Staphylococcus aureus and Escherichia coli (MIC: 250–500 µg/mL). Molecular docking revealed that compounds 2, 36, 41, and 65 showed strong binding affinity for 8ET0, whereas compounds 2, 36, 38, 40, 63, and 65 showed strong binding affinity for 3A4A. This research further increased the diversity of the secondary metabolites of C. fascicularis, laying a foundation for the subsequent development and utilization of this species.

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UHPLC Q-Exactive Orbitrap MS based metabolomics and biological activities of Camellia fascicularis from different geographical regions

Cited by 2 publications

References 49 publications

The uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition

The uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition

Bioactivity-Guided Isolation of Secondary Metabolites from Camellia fascicularis: Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking

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