Úlceras perianales

Barrabés-Torrella, Cristina; Melé‐Ninot, Gemma; Marín-Piñero, Dídac; Iglesias‐Sancho, Maribel

doi:10.1016/j.piel.2021.12.012

Cited by 1 publication

(5 citation statements)

References 18 publications

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“…10 It is relevant to note that allergic contact dermatitis affecting the perianal region, triggered by topical corticosteroids and/or lidocaine, can also contribute to the development of PAUs. 1,11 These findings suggest that the development of PAU may be multifactorial, and diagnosis requires careful consideration of potential contributing factors. The proposed mechanism of PAU induced by antihemorrhoidal ointments (Figure 4) is a combination of topical steroid skin effects: the analgesic effect but also adverse effects of topical lidocaine, compounded by the anatomic properties of the perianal area (humidity and occlusion).…”

Section: Discussionmentioning

confidence: 99%

“…Perianal ulcers can have various causes and result in significant discomfort for affected individuals. 1 Certain medications have been associated with PAU development, such as nicorandil PO (used for the treatment of ischemic heart disease) and suppositories containing ergotamine, ergot derivatives, or paracetamol-codeine (used for pain management). 2,3 In the latter, poor perfusion due to vasoconstriction is probably the main underlying mechanism for PAU development.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the adverse effects of topical lidocaine are typically mild and may include erythema, rash, edema, and dermatitis 10 . It is relevant to note that allergic contact dermatitis affecting the perianal region, triggered by topical corticosteroids and/or lidocaine, can also contribute to the development of PAUs 1,11 …”

Section: Discussionmentioning

confidence: 99%

“…Diagnosing a PAU requires a comprehensive evaluation, including a detailed medical history, physical examination, and laboratory testing. In some cases, a skin biopsy may be necessary to confirm the diagnosis or exclude other possible causes 1 . Here, the authors present two cases of PAU due to an antihemorrhoidal ointment.…”

Section: Introductionmentioning

confidence: 95%

“…In some cases, a skin biopsy may be necessary to confirm the diagnosis or exclude other possible causes. 1 Here, the authors present two cases of PAU due to an antihemorrhoidal ointment. Both patients gave permission to publish their case details and associated images.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Perianal Ulcers from Antihemorrhoidal Ointment: A Case Report and Literature Review

García-Irigoyen,

Guzmán-Bucio,

Molina-López

et al. 2024

Adv Skin Wound Care

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Perianal ulcers (PAUs) related to antihemorrhoidal product use have been recently reported in the literature through a few case reports. However, other etiologies of PAU must be ruled out, including infectious disease, inflammatory disease, malignancy, pressure injuries, radiotherapy, and other topical drugs. In this report, the authors describe two cases of PAUs due to an antihemorrhoidal ointment. In case 1, a 68-year-old woman with a history of hemorrhoids presented with PAUs after using an antihemorrhoidal ointment for 2 months. The ulcers were assessed through a histopathologic study and treated with calcium alginate dressings, with complete re-epithelialization occurring after 2 months. In case 2, a 58-year-old woman with a history of hemorrhoids developed painful PAUs while using an antihemorrhoidal ointment for 2 months. No other probable cause was found, and the ulcers were treated by discontinuing the ointment. The ulcers showed marked improvement, and complete re-epithelialization occurred after 6 weeks without additional treatment.

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Section: Discussionmentioning

confidence: 99%