Ulcerative colitis in Finland:

Lindén, Göran; Möller, Carl

doi:10.1007/bf02553198

Cited by 14 publications

(2 citation statements)

References 11 publications

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“…Characteristics of the 18 cohort studies for UC are shown in Table 1[19-21,23,24,32-35,39-45]. The reported incidence rate ranged from 0.97 to 15.6 per 100,000/year.…”

Section: Resultsmentioning

confidence: 99%

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The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis

et al. 2012

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BackgroundThe objective of this study was to conduct a systematic review with meta-analysis of studies assessing the association between living in an urban environment and the development of the Crohn’s disease (CD) or ulcerative colitis (UC).MethodsA systematic literature search of MEDLINE (1950-Oct. 2009) and EMBASE (1980-Oct. 2009) was conducted to identify studies investigating the relationship between urban environment and IBD. Cohort and case–control studies were analyzed using incidence rate ratio (IRR) or odds ratio (OR) with 95 % confidence intervals (CIs), respectively. Stratified and sensitivity analyses were performed to explore heterogeneity between studies and assess effects of study quality.ResultsThe search strategy retrieved 6940 unique citations and 40 studies were selected for inclusion. Of these, 25 investigated the relationship between urban environment and UC and 30 investigated this relationship with CD. Included in our analysis were 7 case–control UC studies, 9 case–control CD studies, 18 cohort UC studies and 21 cohort CD studies. Based on a random effects model, the pooled IRRs for urban compared to rural environment for UC and CD studies were 1.17 (1.03, 1.32) and 1.42 (1.26, 1.60), respectively. These associations persisted across multiple stratified and sensitivity analyses exploring clinical and study quality factors. Heterogeneity was observed in the cohort studies for both UC and CD, whereas statistically significant heterogeneity was not observed for the case–control studies.ConclusionsA positive association between urban environment and both CD and UC was found. Heterogeneity may be explained by differences in study design and quality factors.

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“…Characteristics of the 18 cohort studies for UC are shown in Table 1[19-21,23,24,32-35,39-45]. The reported incidence rate ranged from 0.97 to 15.6 per 100,000/year.…”

Section: Resultsmentioning

confidence: 99%

“…Urban and rural populations were not consistently defined across all studies. Several studies (n = 10 for UC; n = 11 for CD) did not define an urban and/or rural environment [12,13,16,17,19-31]. The studies that defined this exposure used definitions that varied and some papers stratified by multiple levels of exposure (e.g.…”

Section: Methodsmentioning

confidence: 99%

The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis

et al. 2012

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Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends

Benchimol

Fortinsky

Gozdyra

et al. 2011

Inflammatory Bowel Diseases

858

593

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Geographic variation in the incidence of and mortality from inflammatory bowel disease

Sonnenberg

1986

Diseases of the Colon &Amp; Rectum

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The geographic and temporal variations in mortality from Crohn's disease and ulcerative colitis were investigated. The validity of mortality data as indicators of morbidity was tested by comparing the death rates and incidences among different countries. Death rates from Crohn's disease and ulcerative colitis were high in England, Germany, and the Scandinavian countries, and low in the Mediterranean countries. There was a significant correlation between the incidence and mortality of both diseases among different countries. In addition, the incidence and mortality of Crohn's disease were correlated with those of ulcerative colitis. In countries with a low mortality rate from Crohn's disease, the death rates in men tended to be higher than those in women. In contrast, countries with high death rates from Crohn's disease showed female predominance. No such relationship existed for ulcerative colitis. The overall change in mortality rates during the last 20 to 30 years was characterized by a rise of Crohn's disease and a marked fall of ulcerative colitis. In countries with a high mortality rate from Crohn's disease, the death rates started to fall in recent times. The significant correlations between incidence and mortality show that the death rates from both diseases represent reliable indicators of the morbidity and that the severity of the two diseases is similar in different countries. The marked temporal and geographic variations in both incidence and mortality suggest that environmental factors play an important role in the etiology of both diseases.

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Ulcerative colitis in Finland:

Cited by 14 publications

References 11 publications

The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis

The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis

Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends

Geographic variation in the incidence of and mortality from inflammatory bowel disease

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