Ulcerative lichen planus associated with Sjögren's syndrome

Abstract

Ulcerative lichen planus is a rare variant of lichen planus that is characterized by ulcerations of the feet and toes that are accompanied by toenail loss. However, the nail, oral mucosa, genital mucosa and the scalp are also sometimes affected by ulcerative lichen planus. Several authors have drawn attention to the association of ulcerative lichen planus and autoimmune diseases. We report a patient who had ulcerative lichen planus, with ulcerative erythema on the soles and palms, nail dystrophy and oral lesions, as well as Sjögren's syndrome; she was successfully treated with etretinate.

Association of autoimmune diseases with oral lichen planus: a cross‐sectional, clinical study

“…Lichen planus has been associated with a number of disorders, generally of autoimmune origin: myasthenia gravis, Sjögren's syndrome, ulcerative colitis, psoriasis, thymoma, lupus erythematous, coeliac disease. Likewise, Sjögren's syndrome, lupus erythematous, type 1 diabetes and pernicious anaemia have also been associated with OLP …”

“…The association between OLP and other autoimmune diseases has been a subject of ongoing research, although studies characterizing these associations are scarce. The aim of this study was to investigate the association between autoimmune disease and OLP, diagnosed both clinically and histopathologically and to compare OLP patients with a control population.…”

Erosive lichen planus of the soles: Effective response to prednisone

“…Several authors have drawn attention to the association of ulcerative LP and autoimmune diseases, such as autoimmune thyroiditis, associated with primary biliary cirrhosis and Sjögren’s syndrome 9,10. However, this study did not investigate autoimmune diseases for the referred patient.…”

Lichen Planus

“…No information on dosage are provided (Miyagaki et al 2013 ). Another Japanese woman with ulcerative LP of the sole and Sjogren syndrome was treated with etretinate 30 mg/day for 2 months with nearly resolution of the ulcer (Tsuboi and Katsuoka 2007 ).…”