Ultra low concentration deltamethrin loaded patch development and evaluation of its repellency against dengue vector Aedes (S) albopictus

Chattopadhyay, Pronobesh; Dhiman, Sunil; Devi, Kangujam Adiya; Banerjee, Subham; Rabha, Bipul; Chaurasia, AK; Veer, Vijay

doi:10.1186/1756-3305-6-284

Cited by 18 publications

(16 citation statements)

References 24 publications

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“…DSC results obtained here indicated that the CWO was stable in pectin nanocapsules, which was produced by crosslinking with CaCl 2 . The comparable result was reported previously by Chattopadhyay et al 50 , who used DSC tool to study the compatibility between the polymer, active and other components of the formulations. In both the cases, the shift towards higher temperature was observed in the thermogram of the polymer loaded with active content.…”

Section: Resultssupporting

confidence: 89%

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Kala

Sogan

Naik

et al. 2020

Sci Rep

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The use pesticide is one of the indispensable means to combat mosquito borne diseases. However, the repeated use of synthetic pesticides has induced resistance in the vector pest along with undesirable impact on the environment. The biodegradability, non-persistent and user's safety are the root cause to prefer plant-derived pesticides to synthetic ones. The botanical based pesticides tend to degrade rapidly under the influence of several environmental factors. For the feasible application as pesticides, the plant products are formulated either as liquid or as purely solid. Despite well-established formulation technology in pesticide delivery, their handling trouble is being ignored. There is difficulty in liquid formulation of pesticide products, as they are prone to splashing and spillage, resulting in contamination, wastage and direct exposure to skin; whereas a solid formulation tends to produce dust. In the present work, cedarwood (Cedrus deodara) essential oil embedded pectin nanocapsules were produced. The nanocapsules were characterized according to their morphology, size, encapsulation efficiency and thermal stability. Furthermore, the nanocapsules were impregnated onto mini cotton tea bags to be employed as RTU (ready to use) formulation for treating the breeding sites of mosquitoes. The larvicidal activity of the bags treated with pectin-cedar wood nanocapsules was assessed against malaria vector, Anopheles culicifacies and 98% mortality was recorded till 4 weeks, this suggests its potential and hassle free applications in controlling mosquito vector. Global health threats, primarily due to mosquito borne diseases can devastate communities in social and economic terms and hinder development progress 1. Among the various vector borne diseases, malaria is the major public health issue, which transmits through the bite of Anopheles mosquitoes 2. According to the World Health Organization (WHO) 2019 report, malaria causes 228 million morbidity cases and 405,000 number of mortality 3. Anopheles culicifacies is alone accountable for 60-65% of the malaria burden 4. A Mosquito-borne disease remains a challenge since there is no vaccine, and further drug resistance is an increasing threat. Under these circumstances, vector control plays a vital role and often remains the only way to prevent disease outbreaks. The control of malaria vector, Anopheles, relies upon indoor residual spray (IRS) and insecticide treated nets (ITN) 5. Several other control tools have also been proposed including; nano pesticides, microbial pesticides (that are natural occurring bacteria, fungi and viruses) and pesticides of plant origin, which may act as repellents, oviposition deterrents and larvicides etc. 6,7. A new generation biotechnological tool in mosquito control program, based on genetically modified mosquitoes and sterile Insect Technique (SIT) is also being considered 7,8. Despite significant progress so far, further investigations are needed to determine if genetically modification based strategies can be an effective metho...

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Section: Resultssupporting

confidence: 89%

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Kala

Sogan

Naik

et al. 2020

Sci Rep

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“…In addition to their insecticidal effect, pyrethroids have both spatial repellent and contact irritant effects,[ 17 – 19 ] though excitorepellency is probably the most important effect when pyrethroids are used on clothing. Limited evidence suggests that pyrethroid-resistant populations may actually be more strongly repelled by pyrethroids and other repellents than fully susceptible mosquitoes.…”

Section: Introductionmentioning

confidence: 99%

Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes

et al. 2018

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Pyrethroid-treated clothing is commonly worn for protection against mosquitoes; pyrethroids are both insecticides and repellents. Pyrethroid resistance has become increasingly common in Aedes aegypti, the vector of dengue, Zika, and other arboviruses, but it is not clear whether resistance is associated with reductions in repellency. In order to determine whether long-lasting permethrin impregnated (LLPI) clothing is protective, we used Aedes aegypti from New Orleans, LA (pyrethroid-sensitive) and San Juan, PR (resistant) to measure both lethality and repellency. PCR and Sanger sequencing were used to confirm resistance status by detecting mutations in the kdr gene at positions 1016 and 1534. Arm-in-cage trials of 100 Aedes aegypti females from both populations were performed for 10 minutes to bare arm or an arm clothed in untreated military camouflage or military camouflage impregnated with deltamethrin, permethrin, or etofenprox. Trials were repeated 4–5 times on different days. Number of landings, number of blood meals, and immediate and 24-hour mortality were recorded. Mortality was extremely low in all trials. Compared to untreated cloth, mosquitoes demonstrated a trend towards a 2%-63% reduction in landings and a statistically significant 78–100% reduction in blood feeding on pyrethroid-treated cloth for most insecticides. Effects were observed in both pyrethroid-sensitive and pyrethroid-resistant mosquito populations. Our data show that kdr mutations are associated with pyrethroid resistance but are likely not the only contributors. Pyrethroids appear to maintain repellent effect against resistant mosquitoes. This finding suggests that even in places where pyrethroid resistance is widespread, permethrin still has a role for use as a repellent on clothing to protect against mosquito bites.

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“…Therefore, the current challenge refers to the need to protect people before they go to bed and while they are outdoors. One way of doing this might be to use repellents to prevent mosquitoes from biting and hence a number of products have been developed with this in mind (Kweka et al, 2012;Chattopadhyay et al, 2013;Revay et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of the spatial repellent metofluthrin on landing rates of outdoor biting anophelines in Cambodia, Southeast Asia

Charlwood

Nenhep

Protopopoff³

et al. 2016

Medical Vet Entomology

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The emergence of artemisinin-resistant malaria in Southeast Asia is a major problem. The fact that many people become infected with malaria when they are outside has prompted the development of 'spatial' rather than topical repellents. The respective effects of one or four slow-release emanators of metofluthrin, a pyrethroid, were tested in Pailin, Pursat and Koh Kong, Cambodia. Numbers of mosquitoes counted in outdoor landing catches when one or four emanators were suspended close to the collector were compared with control collections. In Pailin, the effects of emanators on catches in Furvela tent traps and Centers for Disease Control (CDC) light traps suspended underneath houses were also investigated. Rate ratios were used to determine differences. A total of 29 255 mosquitoes were collected over 2934 h of landing collections, 87 nights of tent trapping and 81 nights of light trap capture. In Pailin, landing rates were reduced by 48% by a single emanator and by 67% by four emanators (P < 0.001). Similar reductions were observed in the number of mosquitoes collected in tent traps and the number of anophelines only collected in light traps. Results were similar in Pursat, but, for unknown reasons, those in Koh Kong showed no difference between control and metofluthrin collections (P > 0.05). These findings suggest that although the product can produce a significant effect, it requires further improvement.

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Ultra low concentration deltamethrin loaded patch development and evaluation of its repellency against dengue vector Aedes (S) albopictus

Cited by 18 publications

References 24 publications

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes

Effects of the spatial repellent metofluthrin on landing rates of outdoor biting anophelines in Cambodia, Southeast Asia

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