Ultra-low-dose computed tomography for attenuation correction of cadmium-zinc-telluride single photon emission computed tomography myocardial perfusion imaging

Grossmann, M; Giannopoulos, Andreas A.; Bechtiger, Fabiola A.; Messerli, Michael; Schwyzer, Moritz; Benz, Dominik C.; Kudura, Ken; Gebhard, Cathérine; Gräni, Christoph; Pazhenkottil, Aju P.; Kaufmann, Philipp A.; Buechel, Ronny R.

doi:10.1007/s12350-018-1303-y

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…The first threshold proposed was moved to 145 HU using 100 kVp, 177 HU if 80 kVp is applied and 207 for the 70 kVp, reducing mean effective dose per patient from 0.60 mSv to 0.19 mSv and 0.12 mSv respectively. The data from this previous study was used also by Grossmann et al (2018) to evaluate and develop an attenuation map. The group has validated the previous CCS ultra-low-dose CT in comparison with the reference standard tube potential (120 kVp) for AC in MPI, obtaining accurate and comparable results of the attenuation maps between the 70-80 kVp and the 120 kVp-CT.…”

Section: Opportunities For Combining Ac and Ccsmentioning

confidence: 99%

Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology

Camoni

Santos

Attard

et al. 2020

European J Hybrid Imaging

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The use of hybrid systems is increasingly growing in Europe and this is progressively important for the final result of diagnostic tests. As an integral part of the hybrid imaging system, computed tomography (CT) plays a crucial role in myocardial perfusion imaging diagnostics. Throughout Europe, a variety of equipment is available and also different university curricula of the nuclear medicine technologist are observed. Hence, the Technologist Committee of the European Association of Nuclear Medicine proposes to identify, through a bibliographic review, the recommendations for best practice in computed tomography applied to attenuation correction and calcium score in myocardial perfusion imaging, which courses in the set of knowledge, skills, and competencies for nuclear medicine technologists. This document aims at providing recommendations for CT acquisition protocols and CT image optimization in nuclear cardiology.

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Section: Opportunities For Combining Ac and Ccsmentioning

confidence: 99%

Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology

Camoni

Santos

Attard

et al. 2020

European J Hybrid Imaging

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“…Both CTAC and RAC significantly improved the specificity of detecting RCA stenosis, however only CTAC significantly improved the specificity of diagnosing CAD at a patient level. Recently, with the development of new collimators, reconstruction methods and imaging protocols, the CTAC radiation dose has been significantly reduced while preserving image quality and quantitative measurements ( 52 , 53 ). The dose reduction is greatest for larger patients ( 54 ), in whom AC is most commonly required ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Huang

Yen

et al. 2021

Front. Cardiovasc. Med.

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Background: The aim of this study was to determine whether, and if so how, attenuation correction (AC) improves the diagnostic performance of myocardial perfusion imaging (MPI) in different coronary artery-supplied territories, using coronary angiography as the reference standard.Methods: PubMed and EMBASE were searched until December 2020 for studies evaluating AC MPI for the diagnosis of coronary artery disease (CAD) with vessel-based data. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. For each study, the sensitivity, specificity, diagnostic odds ratios and areas under summary receiver operating characteristic curves (AUC) with 95% confidence intervals were calculated to determine the diagnostic accuracy of AC compared to non-AC MPI. A bivariate mixed-effects model was used to pool the data. Subgroup analyses considering the type of radiotracer and type of AC were performed.Results: A total of 264 articles were screened, of which 22 studies (2,608 patients) were enrolled. Significant improvements in specificity [0.78 vs. 0.58 in overall CAD, 0.87 vs. 0.61 in right coronary artery (RCA)] and diagnostic odds ratios (16 vs. 8 in overall CAD, 18 vs. 7 in RCA) after AC were shown in overall CAD at a patient level and RCA stenosis. Improvements in AUC were also noted. MPI had a similar diagnostic performance for detecting left anterior descending and left circumflex coronary artery stenosis with or without AC. There were trends of decreased sensitivity after AC, but none were significant. Diagnostic odds ratio showed significant improvement after AC only in the technetium-99m subgroup.Conclusion: The results of this study suggest that AC should be applied to MPI to improve the diagnosis of CAD regardless of which type of radiotracer, and that AC MPI can improve the specificity of detecting RCA stenosis.

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“…It has been shown that separately acquired coronary artery calcium scans can be used for AC of SPECT MPI studies (9). The use of separately obtained CT for AC is supported by vendors for routine clinical use (10,11).…”

Section: Solid-state Spect/ct Systemsmentioning

confidence: 99%

Solid-State Detector SPECT Myocardial Perfusion Imaging

Slomka

Miller

et al. 2019

J Nucl Med

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There has been an evolutionary leap in SPECT imaging with the advent of camera systems that use solid-state crystals and novel collimator designs configured specifically for cardiac imaging. Solid-state SPECT camera systems have facilitated dramatic reductions in both imaging time and radiation dose while maintaining high diagnostic accuracy. These advances are related to simultaneous improvement in photon sensitivity due to the collimator and imaging geometry, as well as image resolution due to the improved energy resolution of the new crystals. Improved photon sensitivity has facilitated fast or low-dose myocardial perfusion imaging (MPI), and early dynamic imaging has emerged as a technique for assessing myocardial blood flow with SPECT. Lastly, general-purpose solid-state camera systems and hybrid SPECT/CT systems have also been developed that may have important clinical roles in cardiac imaging. This review summarizes state-of-the-art solid-state SPECT MPI technology and clinical applications, including emerging techniques for SPECT MPI flow estimation. We also discuss imaging protocols used with the new cameras, potential imaging pitfalls, and the latest data providing large-scale validation of the diagnostic and prognostic value of this new technology.

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Ultra-low-dose computed tomography for attenuation correction of cadmium-zinc-telluride single photon emission computed tomography myocardial perfusion imaging

Abstract: Attenuation maps for MPI obtained from ultra-low radiation dose CT scans are interchangeable with attenuation maps from standard-dose CT while offering a substantial reduction in radiation dose exposure.

Cited by 10 publications

References 33 publications

Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology

Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Solid-State Detector SPECT Myocardial Perfusion Imaging

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