Ultra‐processed food is associated with features of metabolic syndrome and non‐alcoholic fatty liver disease

Ivancovsky‐Wajcman, Dana; Fliss-Isakov, Naomi; Webb, Muriel; Bentov, Itay; Shibolet, Oren; Kariv, Revital; Zelber‐Sagi, Shira

doi:10.1111/liv.14996

Cited by 57 publications

(58 citation statements)

References 56 publications

(112 reference statements)

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“…Moreover, this study showed that, in two weeks, participants exposed to the high UPF diet gained 0.9 kg compared to participants exposed to the non-UPF diet, who lost 0.9 kg. The poor nutritional quality of UPFs, the hyper-palatable taste and the use of artificialized matrices with the subsequent effect on satiety feeling have been associated with an increased risk of obesity, which has been attributed to their high content in total fats, saturated fats, and free sugars, [54], and also the use of additives, some of them linked to the deleterious effects of UPFs [55,56]. In this regard, investigations can be found studying additive exposure and long-term potential effects in humans [56].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

et al. 2021

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Ultra-processed foods (UPFs) consumption could affect gut microbiota diversity and profile. We aimed to evaluate the effects of UPFs on microbiota, considering the role of sex. The consumption of UPFs (using NOVA criteria) was assessed with a validated 137-item food-frequency questionnaire. Participants (n = 359) were classified into less than three servings per day (n = 96) of UPFs and more than five (n = 90). Women and men were subclassified following the same criteria. 16S rRNA sequencing was performed from DNA fecal samples, and differences in microbiota were analyzed using EdgeR. The relationship between UPFs and bacteria was assessed by Spearman correlation and comparison of tertiles of consumption. Women who consumed more than five servings/day of UPFs presented an increase in Acidaminococcus, Butyrivibrio, Gemmiger, Shigella, Anaerofilum, Parabacteroides, Bifidobacterium, Enterobacteriales, Bifidobacteriales and Actinobacteria and a decrease in Melainabacter and Lachnospira. Bifidobacterium, Bifidobacteriales and Actinobacteria was positively associated with pizza and Actinobacteria with industrially processed dairy in women. Men who consumed more than five servings/day presented an increase of Granulicatella, Blautia, Carnobacteriaceae, Bacteroidaceae, Peptostreptococcaceae, Bacteroidia and Bacteroidetes and a decrease of Anaerostipes and Clostridiaceae. Bacteroidia and Bacteroidetes correlated positively with industrially processed meat. This study suggests that UPFs may affect microbiota composition differently in women and men.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

et al. 2021

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“…Fresh/frozen fruits and vegetables, fresh meat, fresh milk, eggs, nuts, and whole-grain are some examples of MPFs; and UPFs can be addressed as industrial formulas with multiple ingredients, including sweetened beverages, refined cereal and bread, processed cheese and processed meats products, pizza, and confectionary [ 55 ]. Previous studies have shown that dietary patterns rich in UPFs are associated with increased risk of several cardiometabolic disorders such as metabolic syndrome, cardiovascular diseases, diabetes, and obesity [ 56 ], while the strong inverse relationship of MPFs intake and obesity has been observed [ 57 ]. UPFs are characterized by low nutritional quality, high energy density, which included a high amount of simple carbohydrates, saturated fats, and sodium; while they contain a lower amount of fiber, vitamins, minerals, and proteins in comparison with MPFs [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that dietary patterns rich in UPFs are associated with increased risk of several cardiometabolic disorders such as metabolic syndrome, cardiovascular diseases, diabetes, and obesity [ 56 ], while the strong inverse relationship of MPFs intake and obesity has been observed [ 57 ]. UPFs are characterized by low nutritional quality, high energy density, which included a high amount of simple carbohydrates, saturated fats, and sodium; while they contain a lower amount of fiber, vitamins, minerals, and proteins in comparison with MPFs [ 56 ]. Salome et al reported that higher energy intake from MPFs was related to higher animal protein intake, better plant protein diversity, increased diet quality, and remarkably decreased risk of cardiometabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluating type and amount of dietary protein in relation to metabolic syndrome among Iranian adults: cross-sectional analysis of Fasa Persian cohort study

Jamshidi

Farjam

Ekramzadeh

et al. 2022

Diabetol Metab Syndr

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Background and aim Metabolic syndrome is characterized by several conditions including abdominal obesity, dyslipidemia, impaired glucose levels, and hypertension; which all are directly associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. This study aimed to evaluate the association of the amount and source of dietary protein with the risk of metabolic syndrome and its components in adult men and women. Material and method This study was performed using Persian cohort data, Fasa branch, which included 3660 men and 5262 women. Individuals were divided into five groups for total dietary proteins, plant proteins, and animal proteins using the quintiles, and the odds of incidence for metabolic syndrome and each component was evaluated. Results A higher intake of total protein was associated with lower odds of having metabolic syndrome (OR: 0.24 95% CI 0.18–0.33, P-trend < 0.001 in men, OR: 0.42 95% CI 0.34–0.51, P-trend < 0.001 in women) and all of its components. men (OR: 0.35 95% CI 0.25–0.48, P-trend < 0.001) and women (OR: 0.41 95% CI 0.33–0.52, P-trend < 0.001) in the highest quintile of plant protein intake had a reduced prevalence of metabolic syndrome and its components. An increased animal protein intake was associated with a lower prevalence of metabolic syndrome (P-trend < 0.001), a declined risk of having elevated triglycerides (P-trend = 0.016) in men, and a reduced risk of having abdominal obesity in men (P-trend < 0.001) and women (P-trend < 0.001). Conclusion A higher consumption of total protein and plant protein was associated with a lower prevalence of metabolic syndrome and its components. Increased consumption of animal protein seemed to be related to a lower prevalence abdominal obesity. Also, only in men, animal protein was associated with decreased risk of having metabolic syndrome.

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“…In particular, for individual diseases, risk factors have been identified that show extensive overlap with each other. Particular attention has been given to diet, for which conditions of high risk have been identified in the use of foods with high protein and lipid content, especially industrial ultra-processed food [43]. An examination of this topic is beyond the scope of this commentary.…”

Section: Sustainability Perspectivesmentioning

confidence: 99%

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Biganzoli¹,

Demicheli²

2021

Preprint

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The paradigm of the Somatic Mutation Theory (SMT) is failing and a new paradigm is in the making but not yet established. What is being challenged is a conceptual approach that involves the entire human biology and the development of chronic diseases. The behavior of breast cancer is well compatible with the concept that the primary tumor is able to control its microscopic metastases, in the same way that an organ (e.g., the liver) is able to control its physiological size. This finding suggested that breast cancer and its metastases may behave as an organoid. The new paradigm under construction considers the origin of tumors as a disturbance in the communication network between tissue cell populations and between cells and extracellular matrix, and supports a systemic approach to the study of both healthy and pathologic tissues. The commentary provides a rationale for the role of physical exercise in the control of tumor dormancy according to a human evolutionary perspective.

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Ultra‐processed food is associated with features of metabolic syndrome and non‐alcoholic fatty liver disease

Cited by 57 publications

References 56 publications

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

Evaluating type and amount of dietary protein in relation to metabolic syndrome among Iranian adults: cross-sectional analysis of Fasa Persian cohort study

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

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