Ultra-selective fiber optic SPR platform for the sensing of dopamine in synthetic cerebrospinal fluid incorporating permselective nafion membrane and surface imprinted MWCNTs-PPy matrix

Pathak, Anisha; Gupta, Banshi D.

doi:10.1016/j.bios.2019.03.023

Cited by 71 publications

(39 citation statements)

References 35 publications

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“…In another biosensor development, CNTs are employed as a matrix for the molecular imprinting (MIP) of dopamine (DA), providing a generic platform for the sensing of neurotransmitters [92]. The MIP on the surface of CNTs encompasses the advantages of high sensitivity and selectivity due to the easy removal and uptake of the analyte during sensing, large surface to volume ratio providing increased sensing hotspots, and a stable composite with imprinting conducting polymer (polypyrrole; PPy) due to binding in a de-localized π-electron cloud of CNTs and PPy.…”

Section: Carbon Nanomaterials-based Plasmonic Sensorsmentioning

confidence: 99%

“…SEM images of ( a ) as obtained MWCNTs, ( b ) DA embedded MWCNTs-PPy matrix, ( c ) DA imprinted MWCNTs-PPy matrix, ( d ) Nafion/MWCNTs-PPy MIP nanocomposite, and ( e ) UV-vis spectra of the MWCNTs-PPy MIP nanocomposite during seven elution steps. Reprinted with permission from [92]. Copyright 2019 Elsevier.…”

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Carbon-Based Nanomaterials for Plasmonic Sensors: A Review

Gupta

Pathak

Semwal

2019

Sensors

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The surface plasmon resonance (SPR) technique is a remarkable tool, with applications in almost every area of science and technology. Sensing is the foremost and majorly explored application of SPR technique. The last few decades have seen a surge in SPR sensor research related to sensitivity enhancement and innovative target materials for specificity. Nanotechnological advances have augmented the SPR sensor research tremendously by employing nanomaterials in the design of SPR-based sensors, owing to their manifold properties. Carbon-based nanomaterials, like graphene and its derivatives (graphene oxide (GO)), (reduced graphene oxide (rGO)), carbon nanotubes (CNTs), and their nanocomposites, have revolutionized the field of sensing due to their extraordinary properties, such as large surface area, easy synthesis, tunable optical properties, and strong compatible adsorption of biomolecules. In SPR based sensors carbon-based nanomaterials have been used to act as a plasmonic layer, as the sensitivity enhancement material, and to provide the large surface area and compatibility for immobilizing various biomolecules, such as enzymes, DNA, antibodies, and antigens, in the design of the sensing layer. In this review, we report the role of carbon-based nanomaterials in SPR-based sensors, their current developments, and challenges.

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Section: Carbon Nanomaterials-based Plasmonic Sensorsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Carbon-Based Nanomaterials for Plasmonic Sensors: A Review

Gupta

Pathak

Semwal

2019

Sensors

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“…CNTs have exceptional wavelength conversion function, particularly the adjustable near-infrared emission, which represents fluctuations in local dielectric function but is resistant to permanent photobleaching. In addition, they show high luminous intensity and excellent luminous properties, which are ideal for optical biosensing [75,76,77,78,79,80]. CNTs have only a sixth of the density of steel but are 100 times stronger, allowing their use in fabricating piezoresistive sensors [81,82,83,84].…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

“…Optical sensors based on surface plasmon resonance (SPR) using CNT have also been reported. Pathak and Gupta developed a polypyrrole (PPy) MIP on carboxylated multi-walled carbon nanotubes (CMWCNT) with a permselective nafion membrane for the SPR detection of dopamine (DA) [77]. This sensor demonstrated a wide dynamic range of 10 −9 –10 −5 M with an LOD of 18.9 pM in synthetic cerebrospinal fluid.…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

188

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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