2011
DOI: 10.4021/cr11e
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Ultra-Sensitive C-Reactive Protein (US-CRP) in Patients With Periodontal Disease and Risk of Acute Myocardial Infarction

Abstract: BackgroundThe purpose of this study was to determine if the US-CRP values associated with periodontal disease are risk markers for Acute Myocardial Infarction (AMI) and to determine if the US-CRP levels associated with recent AMI are higher in patients with Periodontal disease.MethodsIn order to meet the goal of the study, a case control study design was conducted. The analysis sample consisted of 401 adults (30 - 75 years old), living in Bogota D.C., Colombia, from the Hospital Universitario San Ignacio, the … Show more

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Cited by 5 publications
(5 citation statements)
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“…9 In the current study, individuals of 25 years and above were invited to participate as CP commonly affects middleaged adults and elderly. 10 Several biochemical markers of systemic inflammation have been identified in periodontitis. The quest for markers like CRP, that are indicative of periodontal disease, is a long one and the correlation of marker levels with systemic disease multiplies the importance of such markers.…”
Section: Discussionmentioning
confidence: 99%
“…9 In the current study, individuals of 25 years and above were invited to participate as CP commonly affects middleaged adults and elderly. 10 Several biochemical markers of systemic inflammation have been identified in periodontitis. The quest for markers like CRP, that are indicative of periodontal disease, is a long one and the correlation of marker levels with systemic disease multiplies the importance of such markers.…”
Section: Discussionmentioning
confidence: 99%
“…It was not the intention of our study to stratify periodontitis into mild, moderate or severe categories. With regard to the severity of periodontal disease, there is evidence of lack of standardization across studies for measuring attachment loss and disease activity . Furthermore, the European consensus in periodontal health and CVD has questioned the most appropriate way to measure periodontal disease, either by destruction (disease consequence) or by exposure itself in terms of infection load or host response .…”
Section: Discussionmentioning
confidence: 99%
“…Periodontitis is a chronic inflammatory disease that occurs commonly in middle‐aged adults and elderly people . Periodontal pathogens affect local and systemic immune and inflammatory responses.…”
mentioning
confidence: 99%
“…These pro-inflammatory cytokines included interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-a, as well as matrix metalloproteinases [ 26 28 ]. As the severity of periodontitis increases, so does the concentration of circulating inflammatory mediators which gradually accumulate to form a systemic inflammatory response [ 29 , 30 ]. The long-term activity of specific bacteria in periodontitis stimulated the secretion of C-reactive protein [ 31 ].…”
Section: Discussionmentioning
confidence: 99%