Ultra-sensitive voltammetric sensor for trace analysis of carbamazepine

Veiga, Alfredina; Dordio, Ana V.; Carvalho, A.J. Palace; Teixeira, Dora Martins; Teixeira, Jorge Ginja

doi:10.1016/j.aca.2010.06.031

Cited by 60 publications

(30 citation statements)

References 36 publications

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“…Chromatographic methods are the most commonly applied ones for the determination of CBZ or its photodegradation products in different matrices , although spectrophotometric, mass spectrometric, electrochemical and capillary electrophoretic methods have also been proposed [40][41][42][43][44][45][46][47]. Since CBZ is not fluorescent in solution, fluorimetric methods for its determination have been developed in a nylon surface [48] or through the formation of fluorescent derivatives by oxidation with Ce(IV) [49,50], permanganate [51] and lead dioxide [52], or by photochemical reaction [53].…”

Section: Introductionmentioning

confidence: 99%

Second-order advantage with excitation–emission photoinduced fluorimetry for the determination of the antiepileptic carbamazepine in environmental waters

Lozano

Escandar

2013

Analytica Chimica Acta

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A photochemically induced fluorescence system combined with second-order chemometric analysis for the determination of the anticonvulsant carbamazepine (CBZ) is presented. CBZ is a widely used drug for the treatment of epilepsy and is included in the group of emerging contaminant present in the aquatic environment. CBZ is not fluorescent in solution but can be converted into a fluorescent compound through a photochemical reaction in a strong acid medium. The determination is carried out by measuring excitation-emission photoinduced fluorescence matrices of the products formed upon ultraviolet light irradiation in a laboratory-constructed reactor constituted by two simple 4 W germicidal tubes. Working conditions related to both the reaction medium and the photoreactor geometry are optimized by an experimental design. The developed approach enabled the determination of CBZ at trace levels without the necessity of applying separation steps, and in the presence of uncalibrated interferences which also display photoinduced fluorescence and may be potentially present in the investigated samples. Different second-order algorithms were tested and successful resolution was achieved using multivariate curve resolution-alternating least-squares (MCR-ALS). The study is employed for the discussion of the scopes and yields of each of the applied second-order chemometric tools. The quality of the proposed method is probed through the determination of the studied emerging pollutant in both environmental and drinking water samples. After a pre-concentration step on a C18 membrane using 50.0 mL of real water samples, a prediction relative error of 2% and limits of detection and quantification of 0.2 and 0.6 ng mL(-1) were respectively obtained.

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Section: Introductionmentioning

confidence: 99%

Second-order advantage with excitation–emission photoinduced fluorimetry for the determination of the antiepileptic carbamazepine in environmental waters

Lozano

Escandar

2013

Analytica Chimica Acta

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“…They therefore offer interesting alternatives to replace the methods that are currently in use. Teixeira et al 19 described the voltammetric determination of carbamazepine at a multi-walled carbon nanotubes (MWCNTs) film-coated glassy carbon electrode (GCE) and Jaldappagari et al 20 investigated the electrochemical behavior of carbamazepine (CBZ) at a fullerene-C 60 modified glassy carbon electrode. These included polarography in which the electrochemical reduction of CBZ at a mercury drop electrode was studied, 14,15 potentiometry with polymer membrane-based ion-selective electrodes, 16 more recently, described by Garcia et al 17 , the determination of carbamazepine in pharmaceutical solutions using differential-pulse adsorptive stripping voltammetry and the oxidation properties of the molecule with different modified and the unmodified carbon electrodes.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behaviors and electrochemical determination of carbamazepine at ionic liquid modified carbon paste electrode in the presence of sodium dodecyl sulfate

Duan

Zuo-ning

2012

J Serb Chem Soc

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The electrochemical behavior and electrochemical determination of carbamazepine (CBZ) at hydrophobic ionic liquid 1-Benzyl-3-Methylimidazole hexafluorophosphate ([BnMIM]PF6) modified carbon paste electrode ([BnMIM]PF6/CPE) in the presence of sodium dodecyl sulfate (SDS) were investigated. A well-defined and sensitive oxidation peak was observed at [BnMIM]PF6/CPE in the presence of SDS and 0.10 M phosphate buffer solution (pH 6.80). The oxidation peak current of CBZ increased significantly at [BnMIM]PF6/CPE in the presence of SDS compared with that in the absence of SDS at carbon paste electrode. It suggested that both SDS and [BnMIM]PF6/CPE show an obvious enhancing effect on the electrochemical oxidation of CBZ. The electrochemical kinetic parameters for CBZ at [BnMIM]PF6/CPE in aqueous SDS solutions were also determined by Chronocoulometry and Chronoamperometry. Finally, the experimental conditions were optimized, and a new electrochemical method of determination for CBZ had been established. The oxidation peak current was linearly dependent on CBZ concentration in the range of 7.0 μM to 0.7 mM with a detection limit of 0.98 μM (signal to noice ratio, S/N = 3). The relative standard deviation for six determinations of 0.10 mM CBZ was between 1.40 and 2.13%. The proposed method was applied in the determination of CBZ in commercial tablet samples

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“…CBZ, as one of the most widely used antiepileptic drugs, is successfully prescribed in the treatment of psychomotor, generalized tonic–clonic seizures and complex partial seizures. In a voltammetric method [ 114 ] for analysis of CBZ, dihexadecyl hydrogen phosphate was used as a dispersing agent to obtain a homogeneous dispersion of MWCNTs and to form a uniform and stable MWCNT film on the surface of a GCE. The LOD of the method was 40 nM.…”

Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

et al. 2014

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Nanomaterial-modified detection systems represent a chief driver towards the adoption of electrochemical methods, since nanomaterials enable functional tunability, ability to self-assemble, and novel electrical, optical and catalytic properties that emerge at this scale. This results in tremendous gains in terms of sensitivity, selectivity and versatility. We review the electrochemical methods and mechanisms that may be applied to the detection of neurological drugs. We focus on understanding how specific nano-sized modifiers may be applied to influence the electron transfer event to result in gains in sensitivity, selectivity and versatility of the detection system. This critical review is structured on the basis of the Anatomical Therapeutic Chemical (ATC) Classification System, specifically ATC Code N (neurotransmitters). Specific sections are dedicated to the widely used electrodes based on the carbon materials, supporting electrolytes, and on electrochemical detection paradigms for neurological drugs and neurotransmitters within the groups referred to as ATC codes N01 to N07. We finally discuss emerging trends and future challenges such as the development of strategies for simultaneous detection of multiple targets with high spatial and temporal resolutions, the integration of microfluidic strategies for selective and localized analyte pre-concentration, the real-time monitoring of neurotransmitter secretions from active cell cultures under electro- and chemotactic cues, aptamer-based biosensors, and the miniaturization of the sensing system for detection in small sample volumes and for enabling cost savings due to manufacturing scale-up. The Electronic Supporting Material (ESM) includes review articles dealing with the review topic in last 40 years, as well as key properties of the analytes, viz., pKa values, half-life of drugs and their electrochemical mechanisms. The ESM also defines analytical figures of merit of the drugs and neurotransmitters. The article contains 198 references in the main manuscript and 207 references in the Electronic Supporting Material.FigureᅟElectronic supplementary materialThe online version of this article (doi:10.1007/s00604-014-1308-4) contains supplementary material, which is available to authorized users.

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Ultra-sensitive voltammetric sensor for trace analysis of carbamazepine

Cited by 60 publications

References 36 publications

Second-order advantage with excitation–emission photoinduced fluorimetry for the determination of the antiepileptic carbamazepine in environmental waters

Second-order advantage with excitation–emission photoinduced fluorimetry for the determination of the antiepileptic carbamazepine in environmental waters

Electrochemical behaviors and electrochemical determination of carbamazepine at ionic liquid modified carbon paste electrode in the presence of sodium dodecyl sulfate

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

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