Ultra-Widefield Swept-Source Optical Coherence Tomography Angiography in the Assessment of Choroidal Changes in Young Adults With Myopia

Gao, Xin; Rao, Cai-Hua; Li, Fang; Liu, Lun; Kejun, Liu

doi:10.1167/tvst.11.12.14

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…None of the parameters for the middle-and large-vessel choroidal layers, except for CT MVCL (r = -0.22, p = 0.04) were significantly associated with changes in AL. Other investigators had noted similar findings for the negative correlation for CT CL , CVD CL and MCVW CL with AL, and positive correlation for CBA CL with AL (15)(16)(17)(18). Taken together, these findings suggest that the increase in AL could have exerted a stretching force on the choroidal vessels, thereby decreasing choroidal vessel width.…”

Section: Discussionsupporting

confidence: 70%

Quantitative assessment of the choroidal vasculature in myopic macular degeneration with optical coherence tomographic angiography

Dan

Ang

et al. 2023

Front. Ophthalmol.

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BackgroundTo assess and compare choroidal morphometric vascular parameters, using optical coherence tomographic angiography (OCTA), in highly myopic adults with and without myopic macular degeneration (MMD).MethodsThis is a clinic-based observational study of 148 eyes with axial length (AL) ≥25mm, enrolled from the high myopia clinic of the Singapore National Eye Centre. MMD was graded from fundus photographs. Swept source OCT (SS-OCT) and OCTA were performed and assessed for choroidal layer thickness (CT) and choroidal vasculature (choroidal vessel density (CVD), choroidal branch area (CBA) and mean choroidal vessel width (MCVW)) in the different choroidal layers (overall choroidal layer (CL), medium-vessel choroidal layer (MVCL), large-vessel choroidal layer (LVCL)).ResultsCTCL (r=-0.58, p<0.001), CTMVCL (r=-0.22, p=0.04), MCVWCL (r=-0.58, p<0.001), and CVDCL (r=-0.19, p=0.02) were negatively correlated with AL, while CBACL (r=0.61, p<0.001) was positively correlated. Compared to eyes with no MMD, eyes with MMD2 had lower CTCL (120.37±47.18µm vs 218.33±92.70µm, p<0.001), CTMVCL (70.57±15.28µm vs 85.32±23.71µm, p=0.04), CTLVCL (101.65±25.36µm vs 154.55±68.41µm, p=0.001) and greater CVDCL (71.10±3.97% vs 66.97±3.63%, p<0.001), CVDMVCL (66.96±2.35% vs 65.06±2.69%, p=0.002), CVDLVCL (68.36±2.56% vs 66.58±2.88%, p=0.012), MCVWMVCL (6.14±0.34µm vs 5.90±0.35µm, p=0.007), and CBACL (12.69±1.38% vs 11.34±1.18%, p<0.001). After adjusting for age, thicker CTCL (odds ratio (OR) 0.98, 95% confidence interval (CI) 0.97-0.99, p<0.001), CTMVCL (OR 0.97 (0.94-0.99), p=0.002) and CTLVCL (OR 0.97 (0.96-0.98, p<0.001) were significantly associated with lower odds of MMD2, while increased CVDCL (OR 1.37 (1.20-1.55), p<0.001), CVDMVCL (OR 1.39 (1.12-1.73), p=0.003), CVDLVCL (OR 1.31 (1.07-1.60), p=0.009), CBACL (OR 2.19 (1.55-3.08), p<0.001) and MCVWMVCL (OR 6.97 (1.59-30.51), p=0.01) was significantly associated with higher odds of MMD2.ConclusionDecrease in choroidal vessel width, density and thickness, and an increase in vascular branching were observed in eyes with long AL. A thinner and denser choroid with greater branching area and vessel width, which may all be signs of hypoxia, were associated with greater odds of MMD2.

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Section: Discussionsupporting

confidence: 70%

Quantitative assessment of the choroidal vasculature in myopic macular degeneration with optical coherence tomographic angiography

Dan

Ang

et al. 2023

Front. Ophthalmol.

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“…TCP, thickest choroidal point. This image was generated by PiView Image System V1 37 , 38 (this software is an application built into the device). …”

Section: Resultsmentioning

confidence: 99%

New findings on choroidal features in healthy people by ultra-widefield swept-source optical coherence tomography angiography

Liu,

Chen,

Leng

et al. 2023

Sci Rep

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To evaluate the distribution of choroidal thickness (CT) and its trend with age in healthy people using 120° ultra-wide field swept-source optical coherence tomography angiography (UWF SS-OCTA). In this cross-sectional observational study, healthy volunteers underwent single imaging of the fundus with UWF SS-OCTA at a field of view (FOV) of 120° (24 mm × 20 mm) centered on the macula. The characteristics of CT distribution in different regions and its changes with age were analyzed. A total of 128 volunteers with a mean age of 34.9 ± 20.1 years and 210 eyes were enrolled in the study. The thickest mean choroid thickness (MCT) was located at the macular region and supratemporal region, followed by the nasal side of the optic disc, and thinnest below the optic disc. The maximum MCT was: 213.40 ± 36.65 μm for the group aged 20–29, and the minimum MCT was: 162.11 ± 31.96 μm for the group aged ≥ 60. After the age of 50, MCT was significantly and negatively correlated decreased with age (r = − 0.358, p = 0.002), and the MCT in the macular region decreased more remarkably compared to other regions. The 120° UWF SS-OCTA can observe the distribution of choroidal thickness in the range of 24 mm × 20 mm and its variation with age. It was revealed that MCT decreased more rapidly in the macular region relative to other regions after 50 years old.

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“…Nevertheless, few studies have directly quantified the vascular density (VD) of choroid vessels (ChdV) within the HM fundus region. Recently, two studies have measured ChdV VD in sub-regions of the peripheral fundus, utilizing dimensions of 20 × 24 mm and 17 × 17 mm [ 3 , 8 ]. Quantitative assessment of choroidal vasculature by SS-OCTA technologyis still in its exploratory stage currently [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Observation of structural and vascular features of retina and choroid in myopia using ultra-widefield SS-OCTA

Si,

Pang,

Song

et al. 2024

BMC Ophthalmol

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Background To find the relationship between the changes of retinal and choriodal structure/ vascular densities (VD) and the myopia progress. Methods 126 eyes of 126 age-matched young participants were divided into three groups: Emmetropia and Low Myopia (EaLM) (33 eyes), Moderate Myopia (MM) (39 eyes), and High Myopia (HM) (54 eyes). Fundus images measuring 12 × 12 mm were captured using ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA). Each image was uniformly divided into nine regions: supra-temporal (ST), temporal (T), infra-temporal (IT), superior (S), central macular area (C), inferior (I), supra-nasal (SN), nasal (N), and infra-nasal (IN). Various structural parameters, including inner retina thickness (IRT), outer retina thickness (ORT), and choroid thickness (CT), were assessed, and the VD of the superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaries (CC), and choroid vessels (ChdV) were quantified. Results CT in upper fundus exhibited a significant reduction from EaLM to MM. Additionally, ORT (ST, S. SN, C, N, IT, I, IN), CT (ST, S, SN, T, C, N, IT, I, IN) and VDs of SCP (ST, S, C, I, IN), DCP (ST, S, T, C, I) and ChdV (T, N, I, IN) were statistically diminished in EaLM compared to HM. Furthermore, IRT (N), ORT (N, IN), CT (S, SN, T, C, IT, I) and VDs of SCP (I, IN) and DCP (I) exhibited significant decreases as MM progressed towards HM. Intriguingly, there was a notable increase in the VD of CC (ST, S, T, C, N) as myopia progressed from MM to HM. Conclusion Significant changes in retinal and choroid structure and vascular density occur as moderate myopia advances to high myopia. Efforts to curb myopia progression to this stage are essential, as the failure to do so may lead to the development of corresponding retinopathy.

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Ultra-Widefield Swept-Source Optical Coherence Tomography Angiography in the Assessment of Choroidal Changes in Young Adults With Myopia

Cited by 11 publications

References 44 publications

Quantitative assessment of the choroidal vasculature in myopic macular degeneration with optical coherence tomographic angiography

Quantitative assessment of the choroidal vasculature in myopic macular degeneration with optical coherence tomographic angiography

New findings on choroidal features in healthy people by ultra-widefield swept-source optical coherence tomography angiography

Observation of structural and vascular features of retina and choroid in myopia using ultra-widefield SS-OCTA

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