Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal‐Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application

Abstract

The challenge of bacterial infection increases the risk of mortality and morbidity in acute and chronic wound healing. Silver nanoparticles (Ag NPs) are a promising new version of conventional antibacterial nanosystem to fight against the bacterial resistance in concern of the drug discovery void. However, there are several challenges in controlling the size and colloidal stability of Ag NPs, which readily aggregate or coalesce in both solid and aqueous state. In this study, a template‐guided synthesis of ultrafine Ag NPs of around 2 nm using water‐soluble and biocompatible γ‐cyclodextrin metal‐organic frameworks (CD‐MOFs) is reported. The CD‐MOF based synthetic strategy integrates AgNO3 reduction and Ag NPs immobilization in one pot achieving dual functions of reduced particle size and enhanced stability. Meanwhile, the synthesized Ag NPs are easily dispersible in aqueous media and exhibit effective bacterial inhibition. The surface modification of cross‐linked CD‐MOF particles with GRGDS peptide boosts the hemostatic effect that further enhances wound healing in synergy with the antibacterial effect. Hence, the strategy of ultrafine Ag NPs synthesis and immobilization in CD‐MOFs together with GRGDS modification holds promising potential for the rational design of effective wound healing devices.

Metal–Organic Frameworks for Biomedical Applications

“…c) The preparation process of ultrafine Ag NPs growth in the pores of CD‐MOF and the surface modification of CD‐MOF. Reproduced with permission 66. Copyright 2019, Wiley‐VCH.…”

“…Interestingly, Zhang and co‐workers described a water‐soluble cyclodextrin MOF (CD‐MOF) as synthetic template, namely GS5‐CL‐Ag@CD‐MOF, which was loaded with ultrafine Ag NPs with Gly‐Arg‐Gly‐Asp‐Ser (GRGDS) peptide functionalization to promote antibacterial effect and wound healing (Figure 8c). 66 The CD‐MOF was composed of γ‐CDs as ligands and K + with a pore size of 0.78 nm. Ag NPs immobilized in the apertures of CD‐MOF exhibited ultrafine particle sizes of 2 nm, high aqueous dispersion, and efficient antibacterial effect against both gram‐negative and gram‐positive bacteria.…”

“…In this review article, we will summarize the recent developments of MOF‐based composite materials including the synthesis and functionalization8–15 and their biomedical applications in the delivery of cargos including drugs, nucleic acids, proteins, and dyes ( Table 1 ),19,21–23,25–29,31b,d,34–41 bioimaging ( Table 2 ),43–45,47–54 antimicrobial ( Table 3 ),57,60–67 biosensing ( Table 4 ),69–73,75–86 and biocatalysis ( Table 5 ). 91–95 Moreover, the potential of MOFs for biomedical applications has been clarified through the analysis of recent examples reported in literature.…”

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

“…GRGDS peptide, which promotes hemostatic plug formation through binding to integrin GPIIb-IIIa receptor on activated platelets was used for further surface functionalization of these MOFs. These surface-functionalized MOFs showed elevated wound healing through hemostatic effects in synergy with the antibacterial effect of silver nanoparticles embedded in MOFs (Shakya et al, 2019).…”

Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

“…Owing to the broad-spectrum antibacterial and few drug resistance properties, silver nanoparticles (AgNPs) have been widely used as antibacterial agent or surface coating in dental instrument, contact lenses, cardiovascular stent, implant, et al (Le Ouay and Stellacci, 2015;Qiao et al, 2019;Shakya et al, 2019). However, during the synthesis process, toxic reducing agent are always used, which may increase the cytotoxicity or potential risk of environment pollution (Duan et al, 2015).…”