Ultrasensitive Determination of Piroxicam at Diflunisal-Derived Gold Nanoparticle-Modified Glassy Carbon Electrode

Piroxicam voltammetric determination by ultra low cost pencil graphite electrode

“…Moreover, SWV did not show cathodic peaks with significant difference from the blank assays ( Figure 2B). PRX seems to have an irreversible electrooxidation reaction in acidic pHs (I pa /I pc > 1.0), as presented in previous studies and in the SWV herein conducted (Shaikh et al, 2017;Torriero et al, 2006).…”

“…In literature, the determination of PRX with the use of many modified electrodes is reported. Some of these modified electrodes show high sensibility with LOD and LOQ values of nM scale (10 -9 mol.L -1 ), however, the preparation of these electrodes require specific materials, expensive equipment, qualified instrumentalists and are often strenuous (Shahrokhian, Jokar, Ghalkhani, 2010;Macêdo, 2018;Gholivand, Malekzadeh, Derakhshan, 2014;Shaikh et al, 2017).…”

A Brief Review of Analytical Methods for the Estimation of TTR Kinetic Stabilizers in Pharmaceutical Formulations and Biological Matrices

“…The proposed method was sensitive and accurate with mean recovery values for the different pharmaceutical formulations of 98.7% and all method validation parameters within the specified limits [64]. Under the optimized conditions methods showed good linearity in the concentration ranges 8x10 -8 -4x10 -6 M, 3x10 -8 -5x10 -7 M and 5x10 -9 -2x10 -7 for 60s, 180s and 300s, respectively [64] and 0.5-50 µM [65] with obtained correlation coefficients over 0.996 [64]. The achieved LOD values were 0.375 ng/ml for MMT-Ca-modified CPE (300s) [64] and 50 nM for the second one [65].…”

“…Voltammetry is another rapid and sensitive analytical technique often applied for the quantification of bulk drug or pharmaceutical formulations in various matrices [61][62][63]. There are two developed voltammetric methods for DIF determination alone [64] or with Piroxicam at DIF-derived gold nanoparticles [65]. It is possible to quantify DIF by using a montmorillonite-Ca-modified carbon paste electrode (MMT-Ca-modified CPE) [64] or differential pulse voltammetry with a modified glassy carbon electrode (DPV GCE) [65].…”

“…There are two developed voltammetric methods for DIF determination alone [64] or with Piroxicam at DIF-derived gold nanoparticles [65]. It is possible to quantify DIF by using a montmorillonite-Ca-modified carbon paste electrode (MMT-Ca-modified CPE) [64] or differential pulse voltammetry with a modified glassy carbon electrode (DPV GCE) [65]. The analyte was measured with an electrolyte consisting of Ag/AgCl/3M KCl in acetate buffer with pH=5.0 using 10% (w/w) Camodified CPE.…”