Ultrasensitive electrochemical sensor for prostate specific antigen detection with a phosphorene platform and magnetic covalent organic framework signal amplifier

Liang, Huan; Xu, Hanbin; Zhao, Yuting; Zheng, Jing; Zhao, Hui; Li, Guoliang; Li, Can-Peng

doi:10.1016/j.bios.2019.111691

Cited by 92 publications

(39 citation statements)

References 42 publications

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“…Electrochemical detection with differential pulse voltammetry and electrochemical impedance spectroscopy allowed low LODs for both the targets with high reproducibility and recyclability [275]. Liang’s group developed a similar electrochemical sensor using magnetic COFs for the determination of PSA in buffer as well as serum [276]. The sandwich immunosensor consisted of an AuNP–phosphorene nanocomposite platform for the immobilization of primary antibodies.…”

Section: Organic Nanomaterials Applications For Healthcare Biosensingmentioning

confidence: 99%

“…Secondary antibody functionalised AuNP loaded magnetic COFs along with methylene blue were responsible for electrochemical signal generation. The research presented an effective assay for PSA detection in the range of 100 fg mL −1 to 10 ng mL −1 , utilising an optimum combination of the superior electron transfer of phosphorene, effective enrichment of methylene blue in the COF, and the excellent catalytic activity of Fe 3 O 4 molecules [276].…”

Section: Organic Nanomaterials Applications For Healthcare Biosensingmentioning

confidence: 99%

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Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

188

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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Section: Organic Nanomaterials Applications For Healthcare Biosensingmentioning

confidence: 99%

Section: Organic Nanomaterials Applications For Healthcare Biosensingmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

188

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“…As far as biosensors are concerned, another contribution was made by Li et al, who prepared a novel electrochemical assay for the determination of prostate specific antigen (PSA) using black phosphorene (BPene) as a platform and magnetic covalent organic frameworks (Fe 3 O 4 @COFs) for signal amplification [60]. BPene was prepared via water-phase exfoliation, using sonication.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Chemistry of Phosphorene: Synthesis, Functionalization and Biomedical Applications in an Update Review

Pica

D’Amato

2020

Inorganics

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The present review aims to highlight the potential of an emerging 2D single element material: phosphorene. Attention is focused on the more recent studies on phosphorene, in terms of synthetic approaches, modification aimed at its stabilization, and potential applications in the biomedical field. Critical aspects for a practical use of phosphorene are discussed, in order to show a realistic scenario and challenges facing researchers.

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“…Recently, electrochemical sensing has gained extensive attention in multiple fields, such as pharmacy, clinical diagnosis, environmental monitoring, and food safety, because of its low cost, sensitive response, and simple operation (Yan et al, 2019 ; Yang et al, 2019 ; Liang et al, 2020 ). COFs have been widely exploited in electrochemical sensing due to their unique properties (Liang et al, 2019a ; Sun et al, 2019a ), which can improve the sensitivity of electrochemical sensors. For example, COFs possess a highly ordered porous structure, functional groups, and available holes, providing a large active surface in which to load electroactive molecules.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensors Based on Covalent Organic Frameworks: A Critical Review

et al. 2020

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The metal-free cousins of metal-organic frameworks, covalent organic frameworks (COFs), are a class of pre-designable crystalline polymers composed of light elements and connected by strong covalent bonds. COFs are being given more and more attention in the electrochemical sensor field due to their fascinating properties, such as highly tunable porosity, intrinsic chemical and thermal stability, structural diversity, large specific surface area, and unique adsorption characteristics. However, there are still some key issues regarding COFs that need to be urgently resolved before they can be effectively applied in electrochemical sensing. In this review, we summarized recent achievements in developing novel electrochemical sensors based on COFs, and discussed the key fundamental and challenging issues that need to be addressed, including the mechanisms underlying charge transport, methods to improve electrical conductivity, immobilization methods on different substrates, synthesis strategies for nanoscale COFs, and the application of COFs in different fields. Finally, the challenges and outlooks in this promising field are tentatively proposed.

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Ultrasensitive electrochemical sensor for prostate specific antigen detection with a phosphorene platform and magnetic covalent organic framework signal amplifier

Cited by 92 publications

References 42 publications

Nanomaterials for Healthcare Biosensing Applications

Nanomaterials for Healthcare Biosensing Applications

Chemistry of Phosphorene: Synthesis, Functionalization and Biomedical Applications in an Update Review

Electrochemical Sensors Based on Covalent Organic Frameworks: A Critical Review

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