Ultrasensitive electrochemiluminescent immunosensing based on trimetallic Au–Pd–Pt/MoS2 nanosheet as coreaction accelerator and self-enhanced ABEI-centric complex

Li, Yujian; Wang, Yihua; Bai, Lijuan; Lv, Heye; Huang, Wei; Liu, Shengchun; Ding, Shijia; Zhao, Min

doi:10.1016/j.aca.2020.05.055

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…In conclusion, there might be three reasons for the low LOD of the developed method: (1) The ECL method is a highly sensitive detection technique itself . (2) The self-enhanced ECL sensing strategy is an effective signal amplification approach as reported. ,, (3) Hg 2+ can specifically react with thymine (T) to form a stable T-Hg 2+ -T complex, which can accelerate the electron transfer than the double-stranded DNA without Hg 2+ . , …”

Section: Resultsmentioning

confidence: 99%

“…27 (2) The self-enhanced ECL sensing strategy is an effective signal amplification approach as reported. 27,32,60 (3) Hg 2+ can specifically react with thymine (T) to form a stable T-Hg 2+ -T complex, which can accelerate the electron transfer than the double-stranded DNA without Hg 2+ . 47,48 Selectivity, Repeatability, and Stability of the Developed Sensing Strategy.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg²⁺ Detection

Zhang²,

Zhao

et al. 2021

ACS Appl. Nano Mater.

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Accurate determination of hazardous Hg2+ is particularly essential for the environment safety and human health. In this work, using Hg2+ as a bridge for the electrochemiluminescence (ECL) reagent and the corresponding coreactant, a new type of self-enhanced ECL nanomaterial was simply and controllably prepared for the first time. In detail, tris (4,4′-dicarboxylicacid-2,2′-bipyridyl) ruthenium(II) dichloride modified with DNA1 (Ru-DNA1) and graphite-like carbon nitride quantum dots linked with DNA2 (QDs-DNA2) were used as the ECL reagent and coreactant, respectively. In the presence of Hg2+, they could be integrated together to form a self-enhanced ECL nanomaterial (Ru-DNA1-Hg2+-QDs-DNA2) via the T-Hg2+-T duplex structure. The ECL signal strength was positively proportional to the concentration of Hg2+. On this basis, sensitive and selective detection of Hg2+ could be achieved by simply modifying the ECL nanomaterial on the electrode surface. Under the optimal experimental conditions, the proposed sensing strategy expressed a superior linear relation with Hg2+ concentration from 10 fM to 1 nM. Moreover, a low detection limit of 3.3 fM with outstanding selectivity, repeatability, and stability for Hg2+ analysis was obtained. In addition, the proposed sensing strategy exhibited reasonable accuracy for real sample assay compared with the atomic fluorescence spectrometry method. From this work, it is suggested that by programming the analytes and the corresponding recognition element, other analytes might also be sensitively and selectively detected using the proposed method.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg²⁺ Detection

Zhang²,

Zhao

et al. 2021

ACS Appl. Nano Mater.

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“…The incorporation of nanocomposites into ECL sensors has been shown to influence the sensitivity, stability, detection range, and detection limit of the sensing platform [ 183 ]. The 2D MoS 2 nanosheets have the advantages of increasing conductivity, providing a high surface area, and improving the photocatalytic performance of ECL sensors [ 81 , 186 , 187 ]. However, only a few studies on ECL sensors based on 2D-MoS 2 /metal-NSs composites have been reported.…”

Section: Propertiesmentioning

confidence: 99%

Functionalization of 2D MoS2 Nanosheets with Various Metal and Metal Oxide Nanostructures: Their Properties and Application in Electrochemical Sensors

2022

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Two-dimensional transition metal dichalcogenides (2D TMDs) have gained considerable attention due to their distinctive properties and broad range of possible applications. One of the most widely studied transition metal dichalcogenides is molybdenum disulfide (MoS2). The 2D MoS2 nanosheets have unique and complementary properties to those of graphene, rendering them ideal electrode materials that could potentially lead to significant benefits in many electrochemical applications. These properties include tunable bandgaps, large surface areas, relatively high electron mobilities, and good optical and catalytic characteristics. Although the use of 2D MoS2 nanosheets offers several advantages and excellent properties, surface functionalization of 2D MoS2 is a potential route for further enhancing their properties and adding extra functionalities to the surface of the fabricated sensor. The functionalization of the material with various metal and metal oxide nanostructures has a significant impact on its overall electrochemical performance, improving various sensing parameters, such as selectivity, sensitivity, and stability. In this review, different methods of preparing 2D-layered MoS2 nanomaterials, followed by different surface functionalization methods of these nanomaterials, are explored and discussed. Finally, the structure–properties relationship and electrochemical sensor applications over the last ten years are discussed. Emphasis is placed on the performance of 2D MoS2 with respect to the performance of electrochemical sensors, thereby giving new insights into this unique material and providing a foundation for researchers of different disciplines who are interested in advancing the development of MoS2-based sensors.

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“…Most of these are immunosensors and employ naturally derived antibodies. They include impedimetric systems with an interdigitated electrode [10] or a three-electrode system [11], spectroelectrochemical systems using TiO 2 nanotube arrays [12] or gold nanopillar substrates [13], electrochemiluminescence systems using Au/Pd/Pt nanoflowers modified with MoS2 nanosheets [14] or a graphene sheet modified with a layer of rubrene [15] or reflectometric interference spectroscopy systems employing glass substrates [16]. As an alternative to immunosensors, enzymatic-based sensors have also been developed [17].…”

Section: Introductionmentioning

confidence: 99%

Plastic Antibody of Polypyrrole/Multiwall Carbon Nanotubes on Screen-Printed Electrodes for Cystatin C Detection

et al. 2021

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This work reports the design of a novel plastic antibody for cystatin C (Cys-C), an acute kidney injury biomarker, and its application in point-of-care (PoC) testing. The synthetic antibody was obtained by tailoring a molecularly imprinted polymer (MIP) on a carbon screen-printed electrode (SPE). The MIP was obtained by electropolymerizing pyrrole (Py) with carboxylated Py (Py-COOH) in the presence of Cys-C and multiwall carbon nanotubes (MWCNTs). Cys-C was removed from the molecularly imprinted poly(Py) matrix (MPPy) by urea treatment. As a control, a non-imprinted poly(Py) matrix (NPPy) was obtained by the same procedure, but without Cys-C. The assembly of the MIP material was evaluated in situ by Raman spectroscopy and the binding ability of Cys-C was evaluated by the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) electrochemical techniques. The MIP sensor responses were measured by the DPV anodic peaks obtained in the presence of ferro/ferricyanide. The peak currents decreased linearly from 0.5 to 20.0 ng/mL of Cys-C at each 20 min successive incubation and a limit of detection below 0.5 ng/mL was obtained at pH 6.0. The MPPy/SPE was used to analyze Cys-C in spiked serum samples, showing recoveries <3%. This device showed promising features in terms of simplicity, cost and sensitivity for acute kidney injury diagnosis at the point of care.

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Ultrasensitive electrochemiluminescent immunosensing based on trimetallic Au–Pd–Pt/MoS2 nanosheet as coreaction accelerator and self-enhanced ABEI-centric complex

Cited by 19 publications

References 25 publications

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg²⁺ Detection

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg²⁺ Detection

Functionalization of 2D MoS2 Nanosheets with Various Metal and Metal Oxide Nanostructures: Their Properties and Application in Electrochemical Sensors

Plastic Antibody of Polypyrrole/Multiwall Carbon Nanotubes on Screen-Printed Electrodes for Cystatin C Detection

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Ultrasensitive electrochemiluminescent immunosensing based on trimetallic Au–Pd–Pt/MoS2 nanosheet as coreaction accelerator and self-enhanced ABEI-centric complex

Cited by 19 publications

References 25 publications

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg2+ Detection

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg2+ Detection

Functionalization of 2D MoS2 Nanosheets with Various Metal and Metal Oxide Nanostructures: Their Properties and Application in Electrochemical Sensors

Plastic Antibody of Polypyrrole/Multiwall Carbon Nanotubes on Screen-Printed Electrodes for Cystatin C Detection

Contact Info

Product

Resources

About

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg²⁺ Detection

DNA-Modified Electrochemiluminescent Tris(4,4’-Dicarboxylicacid-2,2’-Bipyridyl)Ruthenium(II) Dichloride and Assistant DNA-Modified Carbon Nitride Quantum Dots for Hg²⁺ Detection