Ultrasensitive SERS detection of specific oligonucleotides based on Au@AgAg bimetallic nanorods

Ning, Cui-Fang; Tian, Ya-Fei; Zhou, Wen; Yin, Bin‐Cheng; Ye, Bang‐Ce

doi:10.1039/c9an00306a

Cited by 27 publications

(21 citation statements)

References 43 publications

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“…Among all noble metals, Ag nanocrystals have the best SERS activity, but Au nanocrystals are more stable than Ag nanocrystals. Combining Au and Ag can make full use of their individual advantages and synergistic effects for improved chemical and plasmonic properties 24 . Most recently, researchers found that sandwich structures prepared by embedding semiconductors in two layers of plasmonic noble metals showed very high Raman enhancement due to multidimensional plasma coupling 25 .…”

mentioning

confidence: 99%

Self-sustainable and recyclable ternary Au@Cu2O–Ag nanocomposites: application in ultrasensitive SERS detection and highly efficient photocatalysis of organic dyes under visible light

Zheng

Kou

et al. 2021

Microsyst Nanoeng

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Ternary noble metal–semiconductor nanocomposites (NCs) with core–shell–satellite nanostructures have received widespread attention due to their outstanding performance in detecting pollutants through surface-enhanced Raman scattering (SERS) and photodegradation of organic pollutants. In this work, ternary Au@Cu2O–Ag NCs were designed and prepared by a galvanic replacement method. The effect of different amounts of Ag nanocrystals adsorbed on the surfaces of Au@Cu2O on the SERS activity was investigated based on the SERS detection of 4-mercaptobenzoic acid (4-MBA) reporter molecules. Based on electromagnetic field simulations and photoluminescence (PL) results, a possible SERS enhancement mechanism was proposed and discussed. Moreover, Au@Cu2O–Ag NCs served as SERS substrates, and highly sensitive SERS detection of malachite green (MG) with a detection limit as low as 10−9 M was achieved. In addition, Au@Cu2O–Ag NCs were recycled due to their superior self-cleaning ability and could catalyze the degradation of MG driven by visible light. This work demonstrates a wide range of possibilities for the integration of recyclable SERS detection and photodegradation of organic dyes and promotes the development of green testing techniques.

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mentioning

confidence: 99%

Self-sustainable and recyclable ternary Au@Cu2O–Ag nanocomposites: application in ultrasensitive SERS detection and highly efficient photocatalysis of organic dyes under visible light

Zheng

Kou

et al. 2021

Microsyst Nanoeng

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“…The sample solution containing the analyte can be an extract from a real sample (i. e., mostly for food and agricultural applications) or a body-fluid from human or animal (i. e., for biomedical applications). Ning et al [158] functionalized the Au@Ag core-shell nanorods with a Raman reporter molecule and specific DNA (i. e., DNA1) to detect the HPV-16 gene. In parallel, a magnetic bead has also been functionalized with another DNA (i. e., DNA2), where the two designed DNAs were complementary to the target gene of HPV-16.…”

Section: Sers Detection Of Analyte In Solutionmentioning

confidence: 99%

“…On the other hand, metal NPs functionalized with different recognition elements allows the simultaneous detection of multiple analytes, which approach is also known as the Figure 11. a) Schematic illustration of colloidal biosensor using DNA-functionalized Au@AgAg nanorod as SERS probe (top) for the detection of gene HPV-16 using magnetic bead (bottom), [158] b) Synthesis of anisotropic Au nanorod/Polyaniline nanoparticles by a microfluidics approach (top) and change in the Raman intensity in the presence of different ions (bottom), [163] c) development of polymer-coated Au nanorod for simultaneous detection of different Raman active analytes (MO, FITC and R6G) via electrostatic interaction or hydrogen binding, [182] d) Simultaneous detection of ochratoxin A and aflatoxin B1 by selfassembly of Au nanoparticles around magnetic nanoparticle via the hybridization of designed aptamers and their complementary DNAs. [192] plasmonic nose.…”

Section: Sers Detection Of Analyte In Solutionmentioning

confidence: 99%

Metal Nanoparticles‐Enhanced Biosensors: Synthesis, Design and Applications in Fluorescence Enhancement and Surface‐enhanced Raman Scattering

Yaraki

Tan

2020

Chemistry An Asian Journal

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Metal nanoparticles (NP) that exhibit localized surface plasmon resonance play an important role in metalenhanced fluorescence (MEF) and surface-enhanced Raman scattering (SERS). Among the optical biosensors, MEF and SERS stand out to be the most sensitive techniques to detect a wide range of analytes from ions, biomolecules to macromolecules and microorganisms. Particularly, anisotropic metal NPs with strongly enhanced electric field at their sharp corners/edges under a wide range of excitation wavelengths are highly suitable for developing the ultrasensitive plasmonenhanced biosensors. In this review, we first highlight the reliable methods for the synthesis of anisotropic gold NPs and silver NPs in high yield, as well as their alloys and composites with good control of size and shape. It is followed by the discussion of different sensing mechanisms and recent advances in the MEF and SERS biosensor designs. This includes the review of surface functionalization, bioconjugation and (directed/self) assembly methods as well as the selection/screening of specific biorecognition elements such as aptamers or antibodies for the highly selective biodetection. The right combinations of metal nanoparticles, biorecognition element and assay design will lead to the successful development of MEF and SERS biosensors targeting different analytes both in-vitro and in-vivo. Finally, the prospects and challenges of metal-enhanced biosensors for future nanomedicine in achieving ultrasensitive and fast medical diagnostics, high-throughput drug discovery as well as effective and reliable theranostic treatment are discussed.

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“…Ning et al also demonstrated SERS performances obtained by using Au–Ag–Ag nanorod coupled to the magnetic beads through DNA hybridization. A LOD of 1 fM for HPV-16 fragments (human papillomavirus DNA type 16) was found [ 77 ]. Hussain et al reported on the quick contaminant detection in milk by using Au/Ag core-shell nanoparticles.…”

Section: Novelties On Plasmonic and Non-plasmonic Nanomaterials Fomentioning

confidence: 99%

Latest Novelties on Plasmonic and Non-Plasmonic Nanomaterials for SERS Sensing

Barbillon

2020

Nanomaterials

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An explosion in the production of substrates for surface enhanced Raman scattering (SERS) has occurred using novel designs of plasmonic nanostructures (e.g., nanoparticle self-assembly), new plasmonic materials such as bimetallic nanomaterials (e.g., Au/Ag) and hybrid nanomaterials (e.g., metal/semiconductor), and new non-plasmonic nanomaterials. The novel plasmonic nanomaterials can enable a better charge transfer or a better confinement of the electric field inducing a SERS enhancement by adjusting, for instance, the size, shape, spatial organization, nanoparticle self-assembly, and nature of nanomaterials. The new non-plasmonic nanomaterials can favor a better charge transfer caused by atom defects, thus inducing a SERS enhancement. In last two years (2019–2020), great insights in the fields of design of plasmonic nanosystems based on the nanoparticle self-assembly and new plasmonic and non-plasmonic nanomaterials were realized. This mini-review is focused on the nanoparticle self-assembly, bimetallic nanoparticles, nanomaterials based on metal-zinc oxide, and other nanomaterials based on metal oxides and metal oxide-metal for SERS sensing.

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Ultrasensitive SERS detection of specific oligonucleotides based on Au@AgAg bimetallic nanorods

Abstract: We synthesized a novel and sensitive Au/Ag bimetallic SERS-active nanotag, Au–Ag–Ag core–shell–shell nanorod (Au@AgAgNR).

Cited by 27 publications

References 43 publications

Self-sustainable and recyclable ternary Au@Cu2O–Ag nanocomposites: application in ultrasensitive SERS detection and highly efficient photocatalysis of organic dyes under visible light

Self-sustainable and recyclable ternary Au@Cu2O–Ag nanocomposites: application in ultrasensitive SERS detection and highly efficient photocatalysis of organic dyes under visible light

Metal Nanoparticles‐Enhanced Biosensors: Synthesis, Design and Applications in Fluorescence Enhancement and Surface‐enhanced Raman Scattering

Latest Novelties on Plasmonic and Non-Plasmonic Nanomaterials for SERS Sensing

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