Ultrasonic-controlled “explosive” hydrogels to precisely regulate spatiotemporal osteoimmune disturbance

Han, Xiaoyu; Shen, Jieliang; Chen, Shuyu; Cai, Zhengwei; Zhu, Ying; Yi, Weiwei; Li, Kai; Cai, Weiye; Tao, Bailong; Cui, Wenguo; Bai, Dingqun

doi:10.1016/j.biomaterials.2023.122057

Cited by 20 publications

(8 citation statements)

References 64 publications

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“…The encapsulation rate was calculated as described in a previous study. [36,37] Preparation of HA-CHO/HA-NH 2 and UCH Hydrogels: To create HA-CHO, 1 g of HA (Macklin, Shanghai, China) and 450 mg of sodium periodate (Macklin, Shanghai, China) were dissolved and stirred in 90 mL of ddH 2 O at 25 °C. After agitation in the dark for 4 h, the reaction was quenched with 500 μL of ethylene glycol (Aladdin, Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep‐Layer Drug Delivery

Han,

Wang,

Shen

et al. 2023

Advanced Materials

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Conventional coupling agents (such as polyvinylpyrrolidone, methylcellulose, and polyurethane) are unable to efficiently transport drugs through the skin's dual barriers (the epidermal cuticle barrier and the basement membrane barrier between the epidermis and dermis) when exposed to ultrasound, hindering deep and non‐invasive transdermal drug delivery. In this study, nanobubbles prepared by the double emulsification method and aminated hyaluronic acid were crosslinked with aldehyde‐based hyaluronic acid by dynamic covalent bonding through the Schiff base reaction to produce an innovative ultrasound‐nanobubble coupling agent. By amplifying the cavitation effect of ultrasound, drugs can be efficiently transferred through the double barrier of the skin and delivered to deep layers. In an in vitro model of isolated porcine skin, this agent achieved an effective penetration depth of 728 μm with the parameters of ultrasound set at 2 W, 650 kHz, and 50% duty cycle for 20 min. Consequently, drugs can be efficiently delivered to deeper layers non‐invasively. In summary, this ultrasound nanobubble coupling agent efficiently achieves deep‐layer drug delivery by amplifying the ultrasonic cavitation effect and penetrating the double barriers, heralding a new era for non‐invasive drug delivery platforms and disease treatment.This article is protected by copyright. All rights reserved

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Section: Methodsmentioning

confidence: 99%

Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep‐Layer Drug Delivery

Han,

Wang,

Shen

et al. 2023

Advanced Materials

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“…This procedure may also generate a reparative granuloma as a template for further callus production. The acute inflammatory reaction reaches its highest point within 24–48 h and subsides approximately 1 week after the fracture …”

Section: Structural Fundamentals Of Bonementioning

confidence: 99%

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aslam Khan,

Aslam,

Bin Abdullah

et al. 2024

ACS Appl. Bio Mater.

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In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, and interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs and regenerates fractured bones. Bone is a multihierarchical complex structure, and it performs several essential biofunctions, including maintaining mineral balance and structural support and protecting soft organs. Protein-based polymers have gained interest in developing ideal scaffolds as emerging biomaterials for bone fractured healing and regeneration, and it is challenging to design ideal bone substitutes as perfect biomaterials. Several protein-based polymers, including collagen, keratin, gelatin, serum albumin, etc., are potential materials due to their inherent cytocompatibility, controlled biodegradability, high biofunctionalization, and tunable mechanical characteristics. While numerous studies have indicated the encouraging possibilities of proteins in BTE, there are still major challenges concerning their biodegradability, stability in physiological conditions, and continuous release of growth factors and bioactive molecules. Robust scaffolds derived from proteins can be used to replace broken or diseased bone with a biocompatible substitute; proteins, being biopolymers, provide excellent scaffolds for bone tissue engineering. Herein, recent developments in protein polymers for cutting-edge bone tissue engineering are addressed in this review within 3−5 years, with a focus on the significant challenges and future perspectives. The first section discusses the structural fundamentals of bone anatomy and ideal scaffolds, and the second section describes the fabrication techniques of scaffolds. The third section highlights the importance of proteins and their applications in BTE. Hence, the recent development of protein polymers for state-of-the-art bone tissue engineering has been discussed, highlighting the significant challenges and future perspectives.

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“…Treatment modalities usually include conservative and surgical treatment (22,23). Conservative treatment generally uses a fixed external fixator to stabilize the bone in the correct position and allow it to heal naturally.…”

Section: The Effect Of Different Concentrations Of Ha On the Prolifer...mentioning

confidence: 99%

The hyaluronic acid gel promotes the formation of osteoblasts mineralized nodules and fracture callus by regulating the expression of Runx2 and osteocalcin

Jiaquan Yang,

Yulian Liu,

Kunqiang Chen

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Ultrasonic-controlled “explosive” hydrogels to precisely regulate spatiotemporal osteoimmune disturbance

Cited by 20 publications

References 64 publications

Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep‐Layer Drug Delivery

Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep‐Layer Drug Delivery

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

The hyaluronic acid gel promotes the formation of osteoblasts mineralized nodules and fracture callus by regulating the expression of Runx2 and osteocalcin

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