Ultrasonic micronebulizer inferface for high-performance liquid chromatography with flame photometric detector

Karnicky, Joseph F.; Zitelli, L.; Wal, Sj. van der

doi:10.1021/ac00129a023

Cited by 30 publications

(8 citation statements)

References 35 publications

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“…Further, acetonitrile significantly increases the background noise and quenches the detector signal at even low percentages. Various interface designs have been proposed to overcome these problems [201][202][203][204][205]. Kientz and Brinkman [18] recently summarized and discussed the advantages and limitations of the use of flame photometric detection in microcolumn LC.…”

Section: Flame Photometric Detectionmentioning

confidence: 99%

Microcolumn liquid chromatography: instrumentation, detection and applications

Vissers¹,

Claessens

Cramers

1997

Journal of Chromatography A

208

101

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This review discusses many different aspects of microcolumn liquid chromatography (LC) and reflects the areas of microcolumn LC research interest over the past decades. A brief theoretical discussion on a number of major issues, such as column characterisation, chromatographic dilution effects and extracolumn band broadening in microcolumn LC is given. Recent progress in column technology and the demands and developments of instrumentation and accessories for microcolumn LC are also reviewed. Besides that, the developments in a large number of established and also more recent detection techniques for microcolumn LC are also discussed. The potential of hyphenation of microcolumn LC with other techniques, more particularly of multidimensional chromatography and microcolumn LC coupled to mass spectrometry is reviewed. Finally, the perspective of microcolumn LC separation methods is stressed by a number of relevant applications.

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Section: Flame Photometric Detectionmentioning

confidence: 99%

Microcolumn liquid chromatography: instrumentation, detection and applications

Vissers¹,

Claessens

Cramers

1997

Journal of Chromatography A

208

101

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show abstract

“…It has been reported that ultrasonic nebulizers are capable of operating at flow rates down to 20 mL min À1 , without the need for any makeup solvent. 21,22 The ability to provide very high transport efficiency at flow rates in the range of 2-20 mL min À1 suggests good potential for ultrasonic micronebulizers use with microwave induced plasma spectrometry. Ultrasonic nebulizers are popular with inductively coupled plasma (ICP) optical emission (OES) and mass spectrometry (MS).…”

Section: Introductionmentioning

confidence: 99%

Method development for simultaneous multi-element determination of transition (Au, Ag) and noble (Pd, Pt, Rh) metal volatile species by microwave induced plasma spectrometry using a triple-mode microflow ultrasonic nebulizer and in situ chemical vapor generation

Matusiewicz

Ślachciński

2010

J. Anal. At. Spectrom.

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The analytical potential of a coupled continuous-microflow ultrasonic nebulizer triple-mode micro capillary system (m-USN/TCS)-Ar/He mixed gas microwave induced plasma-optical emission spectrometry (MIP-OES) has been evaluated for the purpose of determination of metal volatile species (Au, Ag, Pd, Pt, Rh). An extremely short reaction time between sample, acid and reductant and a rapid separation of the reaction products is obtained by mixing the sample, acid and the sodium borohydride reductant solution at the quartz oscillator, converting liquids into aerosol at the entrance to the spray chamber. A univariate approach and simplex optimization procedure was used to achieve optimized conditions and derive analytical figures of merit. Results showed that the analytical performance of the new system was superior to that of ultrasonic nebulizer dual-mode capillary system. Analytical performance of the ultrasonic nebulization system was characterized by determination of the limits of detection (LODs) and precision (RSDs) with the m-USN/TCS observed at a 15 mL min À1 flow rate. The experimental concentration detection limits for simultaneous determination, calculated as the concentration giving a signal equal to three times of the standard deviation of the blank (LOD, 3s blank criterion, peak height) were 1.2, 1.5, 1.1, 2.9 and 1.8 ng mL À1 for Au, Ag, Pd, Pt and Rh, respectively. The method offers relatively good precision (RSD ranged from 7 to 8%) for liquid analysis and microsampling capability. The accuracy of the method was verified using certified reference materials (TORT-1, NIST 2710, NIST 1643e, IAEA-336) and by the aqueous standard calibration technique. The measured contents of elements in reference materials were in satisfactory agreement with the certified value (Ag) and added amounts (Au, Pd, Pt, Rh).

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“…It has been reported that ultrasonic nebulizers are capable of operating at flow rates down to 20 mL min À1 , without the need for any makeup solvent. 17,18 The ability to provide very high transport efficiency at flow rates in the range of 2-20 mL min À1 suggests good potential for ultrasonic micronebulizers use with plasma spectrometry. Ultrasonic nebulizers become popular with inductively coupled plasma (ICP) optical emission (OES) and mass spectrometry (MS).…”

Section: Introductionmentioning

confidence: 99%