Ultrasonic resonator technology as a new quality control method evaluating gelatin nanoparticles

Fuchs, Sebastian; Winter, Gerhard; Coester, Conrad

doi:10.3109/02652040903079534

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…Polymeric nanodispersion is created simply by dissolving the polymer in the organic phase and by nanoemulsification using an appropriate method of sonication (27). Then, the solvent is slowly removed from the polymer containing nanodroplets to generate nanoparticles.…”

Section: Sonication Methodsmentioning

confidence: 99%

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Babu²,

2014

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Abstract. Nanomedicine refers to biomedical and pharmaceutical applications of nanosized cargos of drugs/vaccine/DNA therapeutics including nanoparticles, nanoclusters, and nanospheres. Such particles have unique characteristics related to their size, surface, drug loading, and targeting potential. They are widely used to combat disease by controlled delivery of bioactive(s) or for diagnosis of life-threatening problems in their very early stage. The bioactive agent can be combined with a diagnostic agent in a nanodevice for theragnostic applications. However, the formulation scientist faces numerous challenges related to their development, scale-up feasibilities, regulatory aspects, and commercialization. This article reviews recent progress in the method of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization.

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Section: Sonication Methodsmentioning

confidence: 99%

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Babu²,

2014

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“…Apart from drug quantification, the URT method has also been proposed to test the quality of gelatin nanoparticles . Interesting is further the use of this technique to monitor manufacturing of nanosuspensions.…”

Section: Pat Sensor Conceptsmentioning

confidence: 99%

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

Simon

Pataki

Marosi

et al. 2015

Org. Process Res. Dev.

359

238

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This multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche. Furthermore, the paper discusses the PAT paradigm from the regulatory science perspective. Given the multidisciplinary nature of PAT, such an endeavour would be almost impossible for a single author, so the concept of a multiauthor review was born. Each section of the multiauthor review has been written by a single expert or group of experts with the aim to report on its own research results. This paper also serves as a comprehensive source of information on PAT topics for the novice reader.

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“…None of those articles analyzes the near-field behavior to optimize a specific sensor design. While there are already sophisticated measurement systems for ultrasonic spectroscopy [9,10,11], they are highly sophisticated and not designed to be used in unknown tool-sensor configurations.…”

Section: Introductionmentioning

confidence: 99%

Sensor Design Optimization for Ultrasonic Spectroscopy Cure Monitoring

Pommer

Sinapius

2018

Sensors

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In the field of cure monitoring, resonant ultrasonic cure monitoring is a unique technique to measure the progression of cure of composites in fully or partially closed tools. It allows for the use of electronic hardware that is less sophisticated than traditional pulse-based ultrasonic systems to obtain accurate results. While this technique is not new, it has been used very rarely. One reason for this is the lack of optimized sensors. Commercially available sensors are optimized for pulse-based ultrasonic testing. This paper establishes a possible optimized sensor design for resonant ultrasound cure monitoring using a multi-parameter FE model.

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Ultrasonic resonator technology as a new quality control method evaluating gelatin nanoparticles

Cited by 8 publications

References 36 publications

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

Sensor Design Optimization for Ultrasonic Spectroscopy Cure Monitoring

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