Ultrasound-assisted ionic liquid/ionic liquid-dispersive liquid–liquid microextraction for the determination of sulfonamides in infant formula milk powder using high-performance liquid chromatography

Gao, Shiqian; Yang, Xiu‐Wei; Wei, Yu Chen; Liu, Zhongling; Zhang, Hanqi

doi:10.1016/j.talanta.2012.07.050

Cited by 80 publications

(30 citation statements)

References 37 publications

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“…Dispersive liquid–liquid microextraction (DLLME), which is another LPME mode, has been widely employed for food analysis . In the case of milk or its derivatives, different methodologies have been proposed for the extraction of diverse analytes as, for example, antibiotics polybrominated diphenyl ethers , cholesterol nonsteroidal anti‐inflammatory drugs , etc. However, up to now, this technique has not been employed for the determination of estrogenic hormones in these matrices.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the combination of a dispersive liquid–liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt

et al. 2015

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In this work, the suitability of a methodology based on dispersive liquid-liquid microextraction (DLLME) has been evaluated for the extraction of four endoestrogens (estriol, 17α-estradiol, 17β-estradiol, and estrone), an exoestrogen (17α-etynylestradiol), and a mycotoxin (zearalenone), together with some of their major metabolites (2-methoxyestradiol, α-zearalanol, β-zearalanol, α-zearalenol, and β-zearalenol) from different types of milk (whole and skimmed cow milk and semiskimmed goat milk) and whole natural yogurt. The methodology includes a previous protein precipitation with acidified ACN and a defatting step with n-hexane. Separation of the analytes, determination, and quantification were developed by MEKC coupled to ESI-MS using a BGE containing an aqueous solution of ammonium perfluorooctanoate as MS friendly surfactant. Calibration, precision, and accuracy studies of the described DLLME-MEKC-MS/MS method were evaluated obtaining a good linearity and LODs in the low micrograms per liter range.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the combination of a dispersive liquid–liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt

et al. 2015

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“…Sulfonamides (SAs), which are synthetic antibiotics , have been widely used as bacteriostatic reagents and growth promoters in animal husbandry owing to their antimicrobial activity and low cost . However, the overuse of SAs can result in the SA residues in the products of animal origin and thereby becomes a potential hazard to human health .…”

Section: Introductionmentioning

confidence: 99%

“…However, the overuse of SAs can result in the SA residues in the products of animal origin and thereby becomes a potential hazard to human health . The SAs and their metabolites could cause Stevens Johnson syndrome, blood disorders, liver damage, hypersensitive allergic reactions, and drug‐resistant problems to human beings . To ensure the safety of food for consumers, European Union and some other countries, including USA, Japan, and China, have legislated for the maximum residue limit of 100 μg/kg for total SAs in foodstuffs of animal origin, such as meat, milk, and eggs .…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, ILs have been widely used as extraction solvents instead of conventional organic solvents in sample preparation due to their unique chemicophysical properties, such as negligible vapor pressure at room temperature, miscibility with water and organic solvents, good solubility for organic and inorganic compounds, high thermal stability, and environmental friendliness . IL‐based dispersive liquid–liquid microextraction , homogeneous liquid–liquid microextraction (HLLME) , single‐drop liquid‐phase microextraction , and aqueous two‐phase extraction have been developed for extracting SA residues in water, honey, milk, animal plasma, and infant formula milk powder. However, all the above methods can only be applied for liquid samples or water‐soluble samples.…”

Section: Introductionmentioning

confidence: 99%

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Matrix solid-phase dispersion coupled with homogeneous ionic liquid microextraction for the determination of sulfonamides in animal tissues using high-performance liquid chromatography

Wang

Jiang

et al. 2015

J. Sep. Science

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Matrix solid-phase dispersion coupled with homogeneous ionic liquid microextraction was developed and applied to the extraction of some sulfonamides, including sulfamerazine, sulfamethazine, sulfathiazole, sulfachloropyridazine, sulfadoxine, sulfisoxazole, and sulfaphenazole, in animal tissues. High-performance liquid chromatography was applied to the separation and determination of the target analytes. The solid sample was directly treated by matrix solid-phase dispersion and the eluate obtained was treated by homogeneous ionic liquid microextraction. The ionic liquid was used as the extraction solvent in this method, which may result in the improvement of the recoveries of the target analytes. To avoid using organic solvent and reduce environmental pollution, water was used as the elution solvent of matrix solid-phase dispersion. The effects of the experimental parameters on recoveries, including the type and volume of ionic liquid, type of dispersant, ratio of sample to dispersant, pH value of elution solvent, volume of elution solvent, amount of salt in eluate, amount of ion-pairing agent (NH4 PF6 ), and centrifuging time, were evaluated. When the present method was applied to the analysis of animal tissues, the recoveries of the analytes ranged from 85.4 to 118.0%, and the relative standard deviations were lower than 9.30%. The detection limits for the analytes were 4.3-13.4 μg/kg.

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“…Additionally, Zhao et al [30] first employed a hydrophilic IL as the dispersive solvent, and this method has been successfully applied to analyze environmental pollutants [31,32]. With regards to the use of hydrophilic ILs as dispersive solvents, Gao et al have reported an application with C 4 MIm-BF 4 in an ultrasound-assisted IL-DLLME mode for the determination of sulfonamides in infant-formula milk powder [33]. They named their method as ultrasound-assisted IL/IL-DLLME, given that two ILs were needed in the method: one hydrophobic IL acting as the extractant; and one hydrophilic IL acting as the dispersive solvent.…”

mentioning

confidence: 99%

Determination of triazine herbicides in juice samples by microwave-assisted ionic liquid/ionic liquid dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography

et al. 2017

J. Sep. Sci.

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A novel microextraction method, termed microwave-assisted ionic liquid/ionic liquid dispersive liquid-liquid microextraction, has been developed for the rapid enrichment and analysis of triazine herbicides in fruit juice samples by high-performance liquid chromatography. Instead of using hazardous organic solvents, two kinds of ionic liquids, a hydrophobic ionic liquid (1-hexyl-3-methylimidazolium hexafluorophosphate) and a hydrophilic ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate), were used as the extraction solvent and dispersion agent, respectively, in this method. The extraction procedure was induced by the formation of cloudy solution, which was composed of fine drops of 1-hexyl-3-methylimidazolium hexafluorophosphate dispersed entirely into sample solution with the help of 1-butyl-3-methylimidazolium tetrafluoroborate. In addition, an ion-pairing agent (NH PF ) was introduced to improve recoveries of the ionic liquid phase. Several experimental parameters that might affect the extraction efficiency were investigated. Under the optimum experimental conditions, the linearity for determining the analytes was in the range of 5.00-250.00 μg/L, with the correlation coefficients of 0.9982-0.9997. The practical application of this effective and green method is demonstrated by the successful analysis of triazine herbicides in four juice samples, with satisfactory recoveries (76.7-105.7%) and relative standard deviations (lower than 6.6%). In general, this method is fast, effective, and robust to determine triazine herbicides in juice samples.

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Ultrasound-assisted ionic liquid/ionic liquid-dispersive liquid–liquid microextraction for the determination of sulfonamides in infant formula milk powder using high-performance liquid chromatography

Cited by 80 publications

References 37 publications

Evaluation of the combination of a dispersive liquid–liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt

Evaluation of the combination of a dispersive liquid–liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt

Matrix solid-phase dispersion coupled with homogeneous ionic liquid microextraction for the determination of sulfonamides in animal tissues using high-performance liquid chromatography

Determination of triazine herbicides in juice samples by microwave-assisted ionic liquid/ionic liquid dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography

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