Ultrasound in dermatology: Principles and applications

Kleinerman, Rebecca; Whang, Talley; Bard, Robert L.; Marmur, Ellen S.

doi:10.1016/j.jaad.2011.12.016

Cited by 184 publications

(197 citation statements)

References 71 publications

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“…We obtained no statistical differences when comparing the Breslow index with the three classes of vascularization but a post hoc test identified that the Breslow index is significantly higher in lesions with hypervascularization compared to those with low vascularity. This confirms that the Breslow index and hypervascularization represents negative prognostic factors for the evolution of patients with CM by increasing the risk of metastasis or relapse [5,11,21,22].…”

Section: Discussionsupporting

confidence: 76%

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Doppler ultrasound and strain elastography in the assessment of cutaneous melanoma: preliminary results

et al. 2015

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Aim: To study the usefulness of color or power Doppler ultrasound (US) in the pre-surgical evaluation of skin melanoma, and to correlate the Doppler characteristics with the appearance on high frequency ultrasound strain elastography (SE) in the preoperative evaluation of cutaneous melanoma. Materials and method: The study included 42 cutaneous melanoma lesions in 39 adult subjects examined between September 2011 and January 2015. Doppler US features (the presence and aspect of vascularization, and the number of vascular pedicles) and elasticity by strain elastography were evaluated together with the pathological results. Results: The melanoma lesions presented hyper-vascularization, with multiple vascular pedicles and stiff appearance. Significant correlations between the thickness of the tumor, measured histopathologically by the Breslow index, and the degree of vascularization (p=0.0167), and number of vascular pedicles (p=0.0065) were identified. Strong correlations between the SE appearance and vascularization on one hand, and SE and the number of vascular pedicles were also identified (p<0.001). Conclusion: Our study demonstrates that Doppler US and SE offer useful information for THE preoperative evaluation of cutaneous melanoma and may contribute to better defining the long term prognosis.

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Section: Discussionsupporting

confidence: 76%

“…The thickness of CM lesions represents a very important element for preoperative management and prognosis, being correlated with the risk of metastasis or relapsing, as well [11,12,21,22]. Catalano et al [11] found that CMs with a thickness greater than 2 mm showing high vascularization have a high risk for a bad prognosis.…”

Section: Discussionmentioning

confidence: 99%

Doppler ultrasound and strain elastography in the assessment of cutaneous melanoma: preliminary results

et al. 2015

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“…One of the critical barriers in early skin-cancer detection is the lack of reliable non-invasive techniques [7] that can detect the cancer at an early stage with high detection probability (i.e., the probability of correctly detecting a malignant lesion) and low false-alarm probability (i.e., the probability of declaring a benign lesion as malignant). Non-invasive techniques for skin-cancer detection include multispectral (MS) imaging [8][9][10], digital dermatoscopy and videodermatoscopy (sequential digital dermatoscopy) [11,12], reflectance-mode confocal microscopy [13], ultrasound [14,15], laser Doppler perfusion imaging [16], and optical coherence tomography (OCT) [17,18]. Each technology presents some restrictions and limitations to non-invasively detect skin cancer with high detection probability and low false-alarm probability.…”

Section: Introductionmentioning

confidence: 99%

Detection theory for accurate and non-invasive skin cancer diagnosis using dynamic thermal imaging

Godoy

Hayat

Ramírez

et al. 2017

Biomed. Opt. Express

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Skin cancer is the most common cancer in the United States with over 3.5M annual cases. Presently, visual inspection by a dermatologist has good sensitivity (> 90%) but poor specificity (< 10%), especially for melanoma, which leads to a high number of unnecessary biopsies. Here we use dynamic thermal imaging (DTI) to demonstrate a rapid, accurate and non-invasive imaging system for detection of skin cancer. In DTI, the lesion is cooled down and the thermal recovery is recorded using infrared imaging. The thermal recovery curves of the suspected lesions are then utilized in the context of continuous-time detection theory in order to define an optimal statistical decision rule such that the sensitivity of the algorithm is guaranteed to be at a maximum for every prescribed false-alarm probability. The proposed methodology was tested in a pilot study including 140 human subjects demonstrating a sensitivity in excess of 99% for a prescribed specificity in excess of 99% for detection of skin cancer. To the best of our knowledge, this is the highest reported accuracy for any non-invasive skin cancer diagnosis method. 1, 93-112 (1948). 35. G. Shi, F. Han, L. Wang, C. Liang, and K. Li, "Q-r curve of thermal tomography and its clinical application on breast tumor diagnosis," Biomed. Opt. Express 6, 1109-1123 (2015). -differentiating facts from fiction, and the impact of high precision quantum well infrared photodetector camera systems, and other factors, in its reemergence," Infrared Phys.

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“…37 Transducers of 20, 75 or 100 MHz frequency have been developed. A resolution of 80-200 μm and penetration depth from 8 to 1.5 mm is possible.…”

Section: High Frequency Ultrasonographymentioning

confidence: 99%

Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

Kardynał¹,

Olszewska

2014

J Dermatol Case Rep

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Over the past few years melanoma has grown into a disease of socio-economic importance due to the increasing incidence and persistently high mortality rates. Melanoma is a malignant tumor with a high tendency to metastasize. Therefore, an extremely important part of the therapeutic process is to identify the disease at an early stage: in situ or stage I. Many tools for early diagnosis of melanoma are available today, including dermoscopy, videodermoscopy and in vivo reflectance confocal microscopy. Other methods such as high frequency ultrasound, optical coherence tomography and electrical impedance spectroscopy may serve as additional diagnostic aids. Modern imaging techniques also allow the monitoring of melanocytic skin lesions over months or years to detect the moment of malignant transformation. This review summarizes the current knowledge about modern diagnostic techniques, which may aid early diagnosis of

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Ultrasound in dermatology: Principles and applications

Cited by 184 publications

References 71 publications

Doppler ultrasound and strain elastography in the assessment of cutaneous melanoma: preliminary results

Doppler ultrasound and strain elastography in the assessment of cutaneous melanoma: preliminary results

Detection theory for accurate and non-invasive skin cancer diagnosis using dynamic thermal imaging

Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

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