Ultrasound modalities and quantification

Postema, Arnoud W.; Idzenga, Tim; Mischi, Massimo; Frinking, Peter; Rosette, Jean de la; Wijkstra, Hessel

doi:10.1097/mou.0000000000000162

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…In CETRUS recordings, the entire prostate is represented by groups of data points; moreover, current studies often focus on the PZ hyperperfusion region rather than the whole prostate and do not conduct tissue analysis of other normal tissue181920. Here, we show that incorporating normal tissue TICs could significantly improve the diagnostic accuracy of nodule TICs for PCa detection (Fig.…”

Section: Discussionmentioning

confidence: 78%

Contrast-enhanced transrectal ultrasound for prediction of prostate cancer aggressiveness: The role of normal peripheral zone time-intensity curves

Huang

Zhu

Zhou

et al. 2016

Sci Rep

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To assess the role of time-intensity curves (TICs) of the normal peripheral zone (PZ) in the identification of biopsy-proven prostate nodules using contrast-enhanced transrectal ultrasound (CETRUS). This study included 132 patients with 134 prostate PZ nodules. Arrival time (AT), peak intensity (PI), mean transit time (MTT), area under the curve (AUC), time from peak to one half (TPH), wash in slope (WIS) and time to peak (TTP) were analyzed using multivariate linear logistic regression and receiver operating characteristic (ROC) curves to assess whether combining nodule TICs with normal PZ TICs improved the prediction of prostate cancer (PCa) aggressiveness. The PI, AUC (p < 0.001 for both), MTT and TPH (p = 0.011 and 0.040 respectively) values of the malignant nodules were significantly higher than those of the benign nodules. Incorporating the PI and AUC values (both, p < 0.001) of the normal PZ TIC, but not the MTT and TPH values (p = 0.076 and 0.159 respectively), significantly improved the AUC for prediction of malignancy (PI: 0.784–0.923; AUC: 0.758–0.891) and assessment of cancer aggressiveness (p < 0.001). Thus, all these findings indicate that incorporating normal PZ TICs with nodule TICs in CETRUS readings can improve the diagnostic accuracy for PCa and cancer aggressiveness assessment.

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Section: Discussionmentioning

confidence: 78%

Contrast-enhanced transrectal ultrasound for prediction of prostate cancer aggressiveness: The role of normal peripheral zone time-intensity curves

Huang

Zhu

Zhou

et al. 2016

Sci Rep

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“…Afterwards, CUDI maps were generated from the CEUS recordings. To generate CUDI parametric maps, first perpixel time-intensity curves (TICs) reflecting contrast dispersion dynamics are extracted from the CEUS recordings [21]. CUDI then measures the cancer-related decrease in contrast dispersion by a spatiotemporal correlation analysis of the TICs [27].…”

Section: Methodsmentioning

confidence: 99%

“…Prostate cancer requires angiogenesis to progress to clinically significant disease and the resultant macro-and microvascular changes are targeted by CEUS [20]. In CEUS, intravascular microbubble contrast agents are used, which allow visualization and quantification of blood flow patterns associated with malignancy [21]. Typically, the inflow and outflow of a contrast bolus are recorded one plane at a time, after which the examiner looks for increased focal enhancement [22].…”

Section: Introductionmentioning

confidence: 99%

“…These signs may be subtle and many aspects of the blood flow dynamics recorded are simply not appreciable to the naked eye. Computer-aided quantification techniques have been proposed to aid in the interpretation of CEUS, potentially improving accuracy, speeding-up reading, and decreasing user dependency [21]. Contrast ultrasound dispersion imaging (CUDI) is based on the fact that cancer-related angiogenetic vascular structures are small in diameter, compressible, highly tortuous and lack normal endothelial lining, leading to less efficient dispersion of blood/contrast [23].…”

Section: Introductionmentioning

confidence: 99%

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Contrast-enhanced ultrasound with dispersion analysis for the localization of prostate cancer: correlation with radical prostatectomy specimens

et al. 2020

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“…Traditional drawbacks of CEUS are its user-dependency, the limited number of planes that can be visualized in one setting, and the fact that the cues that signify a suspicious focus are subtle and present in the image studies in a matter of seconds. To overcome these drawbacks, computer-aided quantification, a relatively new method to analyze CEUS recordings, is used to assist in the CEUS interpretation [16]. In the present trial, we will use the Contrast Ultrasound Dispersion Imaging (CUDI) method with computer-aided quantification developed at the Eindhoven University of Technology [17].…”

Section: Introductionmentioning

confidence: 99%

The prostate cancer detection rates of CEUS-targeted versus MRI-targeted versus systematic TRUS-guided biopsies in biopsy-naïve men: a prospective, comparative clinical trial using the same patients

et al. 2017

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BackgroundThe current standard for Prostate Cancer (PCa) detection in biopsy-naïve men consists of 10–12 systematic biopsies under ultrasound guidance. This approach leads to underdiagnosis and undergrading of significant PCa while insignificant PCa may be overdiagnosed. The recent developments in MRI and Contrast Enhanced Ultrasound (CEUS) imaging have sparked an increasing interest in PCa imaging with the ultimate goal of replacing these “blind” systematic biopsies with reliable imaging-based targeted biopsies.Methods/designIn this trial, we evaluate and compare the PCa detection rates of multiparametric (mp)MRI-targeted biopsies, CEUS-targeted biopsies and systematic biopsies under ultrasound guidance in the same patients. After informed consent, 299 biopsy-naïve men will undergo mpMRI scanning and CEUS imaging 1 week prior to the prostate biopsy procedure. During the biopsy procedure, a systematic transrectal 12-core biopsy will be performed by one operator blinded for the imaging results and targeted biopsy procedure. Subsequently a maximum of 4 CEUS-targeted biopsies and/or 4 mpMRI-targeted biopsies of predefined locations determined by an expert CEUS reader using quantification techniques and an expert radiologist, respectively, will be taken by a second operator using an MRI-US fusion device. The primary outcome is the detection rate of PCa (all grades) and clinically significant PCa (defined as Gleason score ≥7) compared between the three biopsy protocols.DiscussionThis trial compares the detection rate of (clinically significant) PCa, between both traditional systematic biopsies and targeted biopsies based on predefined regions of interest identified by two promising imaging technologies. It follows published recommendations on study design for the evaluation of imaging guided prostate biopsy techniques, minimizing bias and allowing data pooling. It is the first trial to combine mpMRI imaging and advanced CEUS imaging with quantification.Trial registrationThe Dutch Central Committee on Research Involving Human Subjects registration number NL52851.018.15, registered on 3 Nov 2015. Clinicaltrials.gov database registration number NCT02831920, retrospectively registered on 5 July 2016.

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Ultrasound modalities and quantification

Abstract: The novel ultrasound modalities of SWE and CEUS imaging open the door for taking targeted biopsies based on the detection and localization of PCa by these novel modalities. This potentially improves PCa detection wherein significantly reducing the number of biopsy cores.

Cited by 13 publications

References 42 publications

Contrast-enhanced transrectal ultrasound for prediction of prostate cancer aggressiveness: The role of normal peripheral zone time-intensity curves

Contrast-enhanced transrectal ultrasound for prediction of prostate cancer aggressiveness: The role of normal peripheral zone time-intensity curves

Contrast-enhanced ultrasound with dispersion analysis for the localization of prostate cancer: correlation with radical prostatectomy specimens

The prostate cancer detection rates of CEUS-targeted versus MRI-targeted versus systematic TRUS-guided biopsies in biopsy-naïve men: a prospective, comparative clinical trial using the same patients

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