Ultrastructural and biochemical changes in a prokaryote induced by cytoskeletal active drugs

Avermectin inhibits Mucor miehei and Artemia salina chitin synthesis and to a degree DNA synthesis in the former. The antibiotic interferes with chitin turnover in brine shrimp and inhibits Streptomyces antibioticus chitinase activity in vitro. In light of the proposed mode of action of avermectin and the anomolies in the literature, it is proposed that avermectin can kill susceptible organisms not only by a neurotoxic mechanism but also by inhibiting chitin turnover and synthesis at low concentration and thus the molting/ecdysis process.

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Inhibition of chitin metabolism by avermectin in susceptible organisms.

Calcott

Fatig

1984

J. Antibiot.

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Ultrastructural and biochemical changes in a prokaryote induced by cytoskeletal active drugs

Cited by 1 publication

References 22 publications

Inhibition of chitin metabolism by avermectin in susceptible organisms.

Inhibition of chitin metabolism by avermectin in susceptible organisms.

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