Ultrastructural and Biosynthetic Changes in Epitheliocytes of Renal Tubules during the Development of Chronic Renal Failure

Abstract

Structural and functional studies of changes in the tubular compartment during progressive renal dysfunction showed that the major types of damage to tubular cells include dystrophy, degeneration, and atrophy. These changes were associated with inhibition of biosynthetic processes in the tubular epithelium, progressive interstitial fibrosis, and disturbances in the structure and function of peritubular microvessels.