Ultrathin-layer chromatography nanostructures modified by atomic layer deposition

Jim, Steven R.; Foroughi-Abari, A.; Krause, Kathleen M.; Li, P.; Kupsta, Martin; Taschuk, Michael T.; Cadien, Ken; Brett, Michael

doi:10.1016/j.chroma.2013.05.050

Cited by 28 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, SERS is not a separation technique, and therefore it does not always allow for reliable differentiation of several components in a mixture. Among many separation methods, TLC is relatively simple and cheap, and has long been used for primary screening of crude plant drugs and pharmacologically active components of standardized extracts and their formulations [14,19,20]. It can be also used as a purity test of drug substances [21] for preliminary identification.…”

Section: Introductionmentioning

confidence: 99%

Rapid on-site detection of ephedrine and its analogues used as adulterants in slimming dietary supplements by TLC-SERS

Cao

Lou

et al. 2014

Anal Bioanal Chem

View full text Add to dashboard Cite

Ephedrine and its analogues are in the list of prohibited substance in adulteration to botanical dietary supplements (BDS) for their uncontrollable stimulating side effects. However, they were always adulterated illegally in BDS to promote losing weight. In order to avoid detection, various kinds of ephedrine analogues were added rather than ephedrine itself. This has brought about great difficulties in authentication of BDS. In this study, we put forward for the first time a method which combined thin-layer chromatography (TLC) and surface-enhanced Raman scattering (SERS) to directly identify trace adulterant. Ephedrine, pseudoephedrine, methylephedrine, and norephedrine were mixed and used in this method to develop an analytical model. As a result, the four analogues were separated efficiently in TLC analysis, and trace-components and low-background SERS detection was realized. The limit of detection (LOD) of the four analogues was 0.01 mg/mL. Eight common Raman peaks (△υ = 620, 1003, 1030, 1159, 1181, 1205, 1454, 1603 cm(-1)) were extracted experimentally and statistically to characterize the common feature of ephedrine analogues. A TLC-SERS method coupled with common-peak model was adopted to examine nine practical samples, two of which were found to be adulterated with ephedrine analogues. Identification results were then confirmed by UPLC-QTOF/MS analysis. The proposed method was simple, rapid, and accurate and can also be employed to trace adulterant identification even when there are no available reference derivatives on-site or unknown types of ephedrine analogues are adulterated.

show abstract

Section: Introductionmentioning

confidence: 99%

Rapid on-site detection of ephedrine and its analogues used as adulterants in slimming dietary supplements by TLC-SERS

Cao

Lou

et al. 2014

Anal Bioanal Chem

View full text Add to dashboard Cite

show abstract

“…A number of nanomaterials have been explored for use as supports and stationary phases in column, capillary or planar LC methods. As is indicated in Table , both carbon‐based nanomaterials and inorganic nanomaterials have been used in LC applications . Much of this work was been done through the use of columns, however, nanomaterials have also been employed in packed capillaries and in planar techniques such as thin‐layer chromatography (TLC) and ultrathin‐layer chromatography (UTLC) (see Sections –).…”

Section: Types Of Nanomaterials Used In Lcmentioning

confidence: 99%

“…The figures shown for the inorganic nanomaterials are (top) nanostructured columns coated with a material such as aluminum oxide and (bottom) gold nanoparticles coated on graphene‐modified silica. These figures were adapted with permission from .…”

Section: Types Of Nanomaterials Used In Lcmentioning

confidence: 99%

“…The direct placement of nanomaterials on supports has been of particular interest for use in planar chromatography and UTLC as a way for quickly making and modifying these materials . Vapor deposition methods have been used to fabricate or place nanomaterials on supports for UTLC . Atomic‐layer deposition (ALD) has also been used to deposit nanomaterials based on aluminum oxide or zirconium oxide onto silica for UTLC‐based separations .…”

Section: Incorporation or Immobilization Of Nanomaterials In Lc Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials as stationary phases and supports in liquid chromatography

et al. 2017

View full text Add to dashboard Cite

The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the applications that have been explored for such systems. A number of carbon-based nanomaterials and inorganic nanomaterials have been considered for use in LC, ranging from carbon nanotubes, fullerenes and nanodiamonds to metal nanoparticles and nanostructures based on silica, alumina, zirconia and titanium dioxide. Many ways have been described for incorporating these nanomaterials into LC systems. These methods have included covalent immobilization, adsorption, entrapment, and the synthesis or direct development of nanomaterials as part of a chromatographic support. Nanomaterials have been used in many types of LC. These applications have included the reversed-phase, normal-phase, ion-exchange, and affinity modes of LC, as well as related methods such as chiral separations, ion-pair chromatography and hydrophilic interaction liquid chromatography. Both small and large analytes (e.g., dyes, drugs, amino acids, peptides and proteins) have been used to evaluate possible applications for these nanomaterial-based methods. The use of nanomaterials in columns, capillaries and planar chromatography has been considered as part of these efforts. Potential advantages of nanomaterials in these applications have included their good chemical and physical stabilities, the variety of interactions many nanomaterials can have with analytes, and their unique retention properties in some separation formats.

show abstract

“…The advantages of UTLC are the short migration distance and short development times as well as the low‐consumption of mobile phase compared with conventional TLC. As a result, several kinds of fabrication UTLC substrates such as glancing angle deposition, atomic layer deposition, and electro spinning with different materials were demonstrated. Although UTLC can separate mixtures efficiently, the detection limit is low because the sample must be dyeing or plate must be fluorescent contained.…”

Section: Introductionmentioning

confidence: 99%

A high‐performance multifunctional substrate of ultrathin‐layer chromatography (UTLC) and surface‐enhanced Raman scattering (SERS) for rapid biochemical mixture screening

Lee

Lin

Huang

et al. 2018

J Raman Spectroscopy

View full text Add to dashboard Cite

We present a multifunctional substrate of ultrathin‐layer chromatography (UTLC) and surface‐enhanced Raman scattering (SERS), which enables analytes separation and label‐free detection simultaneously. This integrated substrate is composed of silicon nanowires array (SiNWA), decorated with silver nano‐dendrites (AgNDs). This SiNWA is fabricated by a facile and low‐cost metal‐assisted chemical etching process, and the AgNDs are then decorated onto SiNWA by chemical reduction process. These AgNDs provide abundant hot spots by inducing strong localized electric field, which is confirmed by finite‐difference time‐domain simulation calculations. With the optimized multifunctional substrate, the screening of melamine is successfully validated. The high linear dependence of signal intensity and melamine concentrations from 15 to 1,500 ppm with small deviation was carried out by our developed UTLC–SERS substrate, providing a great potential for quantitative detection. Besides, the SERS signals further show a low relative standard deviation of 8.7%, benefited from the calibration by a peak located at 520 cm−1 of silicon. In short, such a low‐cost, high‐stable multifunctional substrate of UTLC and SERS can be readily employed for practical applications of rapid biochemical mixture screening.

show abstract

Ultrathin-layer chromatography nanostructures modified by atomic layer deposition

Cited by 28 publications

References 35 publications

Rapid on-site detection of ephedrine and its analogues used as adulterants in slimming dietary supplements by TLC-SERS

Rapid on-site detection of ephedrine and its analogues used as adulterants in slimming dietary supplements by TLC-SERS

Nanomaterials as stationary phases and supports in liquid chromatography

A high‐performance multifunctional substrate of ultrathin‐layer chromatography (UTLC) and surface‐enhanced Raman scattering (SERS) for rapid biochemical mixture screening

Contact Info

Product

Resources

About