Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through β‐endorphin and methionine‐enkephalin

Abstract

These results suggested that UVA eye irradiation exerts major effects on AOM + DSS-induced colon carcinoma.

Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice

“…The increase in ACTH secretion was most marked in mice with symptoms of AD (data not shown). ACTH has been shown to increase the expression of TSLP through the activity of nucleotide‐binding domain, leucine‐rich‐containing family, pyrin domain‐containing‐3 protein , and AD progression is thought to occur via this mechanism. However, we have previously reported that symptoms of DSS‐induced ulcerative colitis and AOM + DSS‐induced colon cancer can be ameliorated by UVA eye irradiation .…”

“…ACTH has been shown to increase the expression of TSLP through the activity of nucleotide‐binding domain, leucine‐rich‐containing family, pyrin domain‐containing‐3 protein , and AD progression is thought to occur via this mechanism. However, we have previously reported that symptoms of DSS‐induced ulcerative colitis and AOM + DSS‐induced colon cancer can be ameliorated by UVA eye irradiation . We have now also shown that AD symptoms can be reduced by UVA eye irradiation, suggesting a role for clock genes and the circadian rhythm in the progression of the disease.…”

“…For example, during dextran sodium sulfate (DSS)‐induced ulcerative colitis, symptom severity is increased by UVB eye irradiation but ameliorated by UVA eye irradiation . In addition, symptoms are lessened by UVA eye irradiation in both azoxymethane (AOM)‐ and DSS‐induced colon cancers . Finally, UVA eye irradiation has also been shown to affect thymic stromal lymphopoietin (TSLP) , which is closely associated with AD .…”

Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

“…In a mouse model of colon carcinoma induced by azoxymethane and dextran sodium sulphate, UVA radiation exposure of the eye resulted in elevated β-END and methionine-enkephalin, upregulation of their respective receptors, decreased IL-6 and TNF-α ( tumor promoters during early colitis-associated carcinogenesis), increased apoptosis markers and decreased cell proliferation markers compared to control. 257 The authors concluded that UVA irradiation of the murine eye was able to ameliorate symptoms of colon carcinoma through upregulation of β-END and methionine-enkephalin. Another experiment exposed the back skin of mice to UVB radiation and found that levels of CRH, β-END, ACTH and corticosterone were enhanced.…”

“…This experiment also showed a downregulation of the number of epidermal LCs in epidermal sheets derived from the ear and upregulation of secretory IgA in the gut, which indicates that systemic modulation of downstream organs may be plausible after UVA exposure to the eye. In a mouse model of colon carcinoma induced by azoxymethane and dextran sodium sulphate, UVA radiation exposure of the eye resulted in elevated β‐END and methionine‐enkephalin, upregulation of their respective receptors, decreased IL‐6 and TNF‐α ( tumor promoters during early colitis‐associated carcinogenesis), increased apoptosis markers and decreased cell proliferation markers compared to control 257 . The authors concluded that UVA irradiation of the murine eye was able to ameliorate symptoms of colon carcinoma through upregulation of β‐END and methionine‐enkephalin.…”