Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

Barhoumi, Aoune; Liu, Qian; Kohane, Daniel S.

doi:10.1016/j.jconrel.2015.07.018

Cited by 148 publications

(96 citation statements)

References 114 publications

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“…A major limitation of many phototriggerable drug delivery systems [5, 33, 34] is the high dosage of light necessary for drug release or other therapeutic effects to be activated. This problem is exacerbated by attenuation as light passes through tissues in vivo , and can have deleterious effects on effectiveness and safety.…”

Section: Discussionmentioning

confidence: 99%

Multiply repeatable and adjustable on-demand phototriggered local anesthesia

Rwei¹,

Zhan

Wang

et al. 2017

Journal of Controlled Release

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A phototriggerable system whereby patients could repeatedly and non-invasively control the timing and dosage of local anesthesia according to their needs would be beneficial for perioperative pain and perhaps obviate the need for oral narcotics. However, clinical application of phototriggerable systems have been limited by concerns over phototoxicity of lasers and limited tissue penetration of light. To address these limitations, we increased the devices’ effective sensitivity to light by co-delivering a second compound, dexmedetomidine, that potentiates the effect of delivered local anesthetics. The concurrent release of dexmedetomidine enhanced the efficacy of released local anesthetics, greatly increasing the number of triggerable nerve blocks (up to nine triggerable events upon a single injection) and reducing the irradiance needed to induce nerve block by 94%. The intensity and duration of on-demand analgesia could be adjusted by varying the intensity and duration of irradiance, which could not only be delivered by lasers, but also by light-emitting diodes, which are less expensive, safer, and more portable.

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Section: Discussionmentioning

confidence: 99%

Multiply repeatable and adjustable on-demand phototriggered local anesthesia

Rwei¹,

Zhan

Wang

et al. 2017

Journal of Controlled Release

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“…NDDSs formed by light‐responsive polymers can be triggered to dissociate and release the cargo in response to light irradiation. Owing to the clean and convenient nature of light‐triggered processes, light‐responsive NDDSs have been widely applied in drug delivery field …”

Section: Light‐responsive Nddssmentioning

confidence: 99%

Polymer-based drug delivery systems for cancer treatment

Guo

Wang

Xiao

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

116

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This review is focused on the chemical design and synthesis of polymer‐based drug delivery systems, in particular with stimuli‐responsive nanoplatforms for cancer treatment. We provide a brief description of the properties, synthesis and advantages of amphiphilic block copolymers, including polyether‐polyester and polyether‐polyanhydride. As for stimuli‐responsive polymers, we detail the recent innovative techniques for constructing smarter, more precise and optimally tuned nanocarriers that release drug in the disease site. This review is presented in the context of polymer science research, with special attention focused on the tailor‐made polymers containing specific chemical functionalities. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3525–3550

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“…Currently, considerable attentions have been paid to the development of light‐controlled therapeutic systems mainly owing to the appealing advantages of light activation including spatiotemporal precision, easy manipulation, and long history application as a therapy. So far, UV light excitation remains the most commonly used strategy for the photo‐induced therapeutic reagents and imaging probe release in vitro and in vivo . Although its initial success in principle, the widely accepted disadvantages, which UV light has poor capability of tissue penetration and it often inflicts potential biological damage, may greatly limit its further applications in biomedical fields .…”

Section: Photoactivated Drug Delivery and Bioimaging On The Basis Of mentioning

confidence: 99%

Photoactivated drug delivery and bioimaging

Yang

Xing

2016

WIREs Nanomed Nanobiotechnol

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Among the various types of diseases, cancer remains one of the most leading causes of mortality that people are always suffering from and fighting with. So far, the effective cancer treatment demands accurate medical diagnosis, precise surgery, expensive medicine administration, which leads to a significant burden on patients, their families, and the whole national healthcare system around the world. In order to increase the therapeutic efficiency and minimize side effects in cancer treatment, various kinds of stimuli-responsive drug delivery systems and bioimaging platforms have been extensively developed within the past decades. Among them, the strategy of photoactivated approach has attracted considerable research interest because light enables the precise control, in a highly spatial and temporal manner, the release of drug molecules as well as the activation of bioimaging agents. In general, several appropriate photoresponsive systems, which are normally sensitive to ultraviolet (UV) or visible light irradiation to undergo the multiple reaction pathways such as photocleavage and photoisomerization strategy etc. have been mainly involved in the light activated cancer therapies. Considering the potential issues of poor tissue penetration and high photoctotoxicity of short wavelength light, the recently emerged therapies based on long-wavelength irradiation, e.g., near-infrared (NIR) light (700-1000 nm), have displayed distinct advantages in biomedical applications. The light irradiation at NIR window indicates minimized photodamage, deep penetration, and low autofluorescence in living cells and tissues, which are of clinical importance in the desired diagnosis and therapy. In this review article, we introduce the recent advances in light-activated drug release and biological imaging mainly for anticancer treatment. Various types of strategies such as photocage, photo-induced isomerization, optical upconversion, and photothermal release by which different wavelength ranges of light can play the important roles in the controlled therapeutic or imaging agents delivery, and activation will be systemically discussed. In addition, the challenges and future perspectives for photo-based cancer theranostics will be also summarized. WIREs Nanomed Nanobiotechnol 2017, 9:e1408. doi: 10.1002/wnan.1408 For further resources related to this article, please visit the WIREs website.

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Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

Cited by 148 publications

References 114 publications

Multiply repeatable and adjustable on-demand phototriggered local anesthesia

Multiply repeatable and adjustable on-demand phototriggered local anesthesia

Polymer-based drug delivery systems for cancer treatment

Photoactivated drug delivery and bioimaging

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