UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case

Prosolov, Konstantin A.; Комарова, Е. Г.; Kazantseva, E. A.; Ложкомоев, А. С.; Kazantsev, Sergei O.; Бакина, О. В.; Mishina, Marina V.; Зима, А. П.; Кривощеков, С. В.; Хлусов, И. А.; Sharkeev, Yurii P.

doi:10.3390/ma15134643

Cited by 10 publications

(9 citation statements)

References 83 publications

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“…In this case, the behavior of M determines the regulation mechanism of HIF-1α interaction with oxygen in cells: with a lack of oxygen (OH–OH bond); the release of HIF-1α from a cell remains almost unchanged with increasing concentration, and with its excess (ON–O bond) the release is enhanced. It is this effect that is observed experimentally [ 18 , 47 ].…”

Section: Resultsmentioning

confidence: 53%

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Carboxyl Functionalization of N-MWCNTs with Stone–Wales Defects and Possibility of HIF-1α Wave-Diffusive Delivery

Shunaev

Bobenko

Корусенко

et al. 2023

IJMS

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Nitrogen-doped multi-walled carbon nanotubes (N-MWCNTs) are widely used for drug delivery. One of the main challenges is to clarify their interaction with hypoxia-inducible factor 1 alpha (HIF-1α), the lack of which leads to oncological and cardiovascular diseases. In the presented study, N-MWCNTs were synthesized by catalytic chemical vapor deposition and irradiated with argon ions. Their chemical state, local structure, interfaces, Stone–Wales defects, and doping with nitrogen were analyzed by high resolution transmission electron microscopy (HRTEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. Using experimental data, supercells of functionalized N-MWCNTs with an oxygen content of 2.7, 4 and 6 at. % in carboxyl groups were built by quantum chemical methods. Our analysis by the self-consistent charge density functional tight-binding (SCC DFTB) method shows that a key role in the functionalization of CNTs with carboxyl groups belongs to Stone–Wales defects. The results of research in the decoration of CNTs with HIF-1α demonstrate the possibility of wave-diffusion drug delivery. The nature of hybridization and relaxation determines the mechanism of oxygen regulation with HIF-1α molecules, namely, by OH-(OH–C) and OH-(O=C) chemical bonds. The concentration dependence of drug release in the diffusion mode suggests that the best pattern for drug delivery is provided by the tube with a carboxylic oxygen content of 6 at. %.

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Section: Resultsmentioning

confidence: 53%

“…The concentration of a drug released from its carrier varies linearly or exponentially with time, which is normally described by the diffusion equation [ 16 , 17 ]. However, as has been found experimentally, wavelike kinetics of drug release are also possible [ 18 ]. The mechanism of wave-diffusion release is currently unclear.…”

Section: Introductionmentioning

confidence: 94%

Carboxyl Functionalization of N-MWCNTs with Stone–Wales Defects and Possibility of HIF-1α Wave-Diffusive Delivery

Shunaev

Bobenko

Корусенко

et al. 2023

IJMS

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“…In addition, ultrasound might be applied during the MAO process (called UMAO = ultrasound MAO) [579]; there is also a more complicated hybrid UMAOH (=UMAO hybrid) process, which consists of two stages: UMAO with ultrasound treatment for 8 min and subsequent MAO without ultrasound for 2 min. The latter process produces CaPO 4 deposits more suitable for drug delivery applications [580].…”

Section: Micro-arc Oxidation (Mao) Techniquementioning

confidence: 99%

“…As briefly mentioned in Section 5 above, CaPO 4 can be deposited as various biocomposites with numerous additives. Among them, drugs, amino acids, and other biologically active compounds such as hormones, peptides, genes, growth factors and DNA are present [61,580,843,845,[1088][1089][1090][1091][1092][1093][1094][1095][1096][1097]. Antibiotic-containing CaPO 4 deposits were found to show significant in vivo improvements in infection prevention when compared to just CaPO 4 deposits [1089,[1094][1095][1096][1097].…”

Section: Biomedical Applications Of Capo 4 Depositsmentioning

confidence: 99%

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

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A The present overview describes various production techniques for biocompatible calcium orthophosphate (abbreviated as CaPO4) deposits (coatings, films and layers) on the surfaces of various types of substrates to impart the biocompatible properties for artificial bone grafts. Since, after being implanted, the grafts always interact with the surrounding biological tissues at the interfaces, their surface properties are considered critical to clinical success. Due to the limited number of materials that can be tolerated in vivo, a new specialty of surface engineering has been developed to desirably modify any unacceptable material surface characteristics while maintaining the useful bulk performance. In 1975, the development of this approach led to the emergence of a special class of artificial bone grafts, in which various mechanically stable (and thus suitable for load-bearing applications) implantable biomaterials and artificial devices were coated with CaPO4. Since then, more than 7500 papers have been published on this subject and more than 500 new publications are added annually. In this review, a comprehensive analysis of the available literature has been performed with the main goal of finding as many deposition techniques as possible and more than 60 methods (double that if all known modifications are counted) for producing CaPO4 deposits on various substrates have been systematically described. Thus, besides the introduction, general knowledge and terminology, this review consists of two unequal parts. The first (bigger) part is a comprehensive summary of the known CaPO4 deposition techniques both currently used and discontinued/underdeveloped ones with brief descriptions of their major physical and chemical principles coupled with the key process parameters (when possible) to inform readers of their existence and remind them of the unused ones. The second (smaller) part includes fleeting essays on the most important properties and current biomedical applications of the CaPO4 deposits with an indication of possible future developments.

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“…Conventionally, the immersion method is used to form thick polymer coatings, including on metal substrates. For example, Prosolov et al [ 13 ] successfully applied a calcium phosphate coating to Ti samples. However, this approach is used much less frequently for ceramic materials, which may be due to their low wettability.…”

Section: Introductionmentioning

confidence: 99%

Formation of Thick Immersion Coatings and Residual Stress Evaluation in the System ZrB2–ZrO2: Experimental and Numerical Investigation

et al. 2023

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The combination of various oxide ceramics in layered and functionally graded composites allows for the development of novel materials, including for high-temperature applications. This study demonstrates the possibility of obtaining a thick ZrO2-based coating on a ZrB2–SiC ceramic substrate by the immersion method. For better wettability, the porous ZrB2–SiC substrate is treated with cold plasma without changing the structure and phase composition of the surface. Immersion of the substrate in a ZrO2-based slurry results in the formation of a gradient transition layer due to ZrO2 particle penetration into the pore volume. The interfacial residual microstresses are evaluated experimentally. The residual macrostresses in the samples are calculated by finite element simulation. It is shown that the thermal residual stresses in the ZrB2–SiC substrate are compressive and do not exceed 43 MPa. In the ZrO2 coating and transition layers of the composite, the residual stresses are tensile. Their values increase as they get closer to the outer layer of the ZrO2 coating and reach 1525 MPa. This confirms the conclusions about the presence of tensile residual stresses made in the experimental part of the work when observing crack propagation in the surface layers during indentation.

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UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case

Cited by 10 publications

References 83 publications

Carboxyl Functionalization of N-MWCNTs with Stone–Wales Defects and Possibility of HIF-1α Wave-Diffusive Delivery

Carboxyl Functionalization of N-MWCNTs with Stone–Wales Defects and Possibility of HIF-1α Wave-Diffusive Delivery

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Formation of Thick Immersion Coatings and Residual Stress Evaluation in the System ZrB2–ZrO2: Experimental and Numerical Investigation

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