Umbilical activin A concentration as an early marker of perinatal hypoxia

Fiala, Małgorzata; Baumert, Małgorzata; Walencka, Zofia; Paprotny, Magdalena

doi:10.3109/14767058.2012.675373

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…AcA concentrations in cord blood were assessed in 26 hypoxic infants and 60 controls. AcA was higher in hypoxic preterm newborns in a gender-dependent manner [110].…”

Section: Bloodmentioning

confidence: 88%

Early predictors of perinatal brain damage: the role of neurobiomarkers

Bersani

Pluchinotta

Dotta

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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The early detection of perinatal brain damage in preterm and term newborns (i.e. intraventricular hemorrhage, periventricular leukomalacia and perinatal asphyxia) still constitute an unsolved issue. To date, despite technological improvement in standard perinatal monitoring procedures, decreasing the incidence of perinatal mortality, the perinatal morbidity pattern has a flat trend. Against this background, the measurement of brain constituents could be particularly useful in the early detection of cases at risk for short-/long-term brain injury. On this scenario, the main European and US international health-care institutions promoted perinatal clinical and experimental neuroprotection research projects aimed at validating and including a panel of biomarkers in the clinical guidelines. Although this is a promising attempt, there are several limitations that do not allow biomarkers to be included in standard monitoring procedures. The main limitations are: (i) the heterogeneity of neurological complications in the perinatal period, (ii) the small cohort sizes, (iii) the lack of multicenter investigations, (iv) the different techniques for neurobiomarkers assessment, (iv) the lack of consensus for the validation of assays in biological fluids such as urine and saliva, and (v), the lack of reference curves according to measurement technique and biological fluid. In the present review we offer an up-to-date overview of the most promising developments in the use of biomarkers in the perinatal period such as calcium binding proteins (S100B protein), vasoactive agents (adrenomedullin), brain biomarkers (activin A, neuron specific enolase, glial fibrillary acidic protein, ubiquitin carboxyl-terminal hydrolase-L1) and oxidative stress markers.

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“…AcA concentrations in cord blood were assessed in 26 hypoxic infants and 60 controls. AcA was higher in hypoxic preterm newborns in a gender-dependent manner [110].…”

Section: Bloodmentioning

confidence: 88%

Early predictors of perinatal brain damage: the role of neurobiomarkers

Bersani

Pluchinotta

Dotta

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The diagnosis of suspected sepsis was established when at least three clinical signs and two laboratory findings of infection were present. Activin-A is increased during perinatal asphyxia/hypoxia and intraventricular hemorrhage (11)(12)(13)(14)29,38). In addition, maternal activin-A levels are associated with preeclampsia (39) and the use of antidepressants (30).…”

Section: Subjectsmentioning

confidence: 99%

“…Peripheral blood (4 ml) was obtained from healthy neonates (BW > 2,800 g; GA >38 wk (37)(38)(39)(40)(41); n = 9-10), and PBMCs were isolated by Histopaque (Sigma-Aldrich, St Louis, MO). PBMCs were cultured in Roswell Park Memorial Institute medium with GlutaMAX (Invitrogen, Carlsbad, CA) supplemented with 2% penicillin/streptomycin (SigmaAldrich) at 37 °C , 5% CO 2 for 1 h. Nonadherent lymphocytes were collected and cultured for 4, 24, or 48 h in the presence or absence of PHA (0.1 mg/ml; Sigma-Aldrich), as previously described (40).…”

Section: In Vitro Stimulation Of Neonatal Peripheral Blood Leukocytesmentioning

confidence: 99%

Activin-A exerts a crucial anti-inflammatory role in neonatal infections

et al. 2013

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Background: Activin-A is a cytokine with a critical role in infections and associated inflammation in experimental models and humans. Still, the effects of activin-A on neonatal infections remain elusive. Here, we investigated the expression of activin-A in the serum of septicemic preterm and term neonates and in peripheral blood leukocytes stimulated with inflammatory agents in vitro. The role of activin-A in the regulation of inflammatory responses by neonatal leukocytes was delineated. Methods: Peripheral blood was obtained from 37 septicemic neonates between the first and fifth days postinfection and from 35 healthy controls. Isolated monocytes and lymphocytes were stimulated with lipopolysaccharide (LPS) or phytohemagglutinin (PHA) in vitro in the presence of activin-A. Cell proliferation, cytokine, and chemokine release were investigated. results: Activin-A was significantly increased in the serum of preterm septicemic neonates. Neonatal leukocytes secreted copious amounts of activin-A following stimulation, pointing to these cells as an essential source of activin-A in the circulation. Of note, treatment of neonatal leukocytes with activin-A during PHA and LPS stimulation resulted in significantly decreased interleukin (IL)-1β, IL-6, and CXCL8 production, concomitant with a striking increase in the anti-inflammatory mediator, IL-10. conclusion: Our findings uncover activin-A as a novel immunomodulatory agent critical for the control of inflammatory responses in septicemic neonates.

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“…42 In addition, high activin A concentrations were found in serum of newborns with clinical symptoms of perinatal hypoxia. 43 Despite these promising clinical observations, mechanisms, and influencing factors of activin A regulation in neonates have not been consistently explained. Preterm neonates developing intracerebral hemorrhage showed elevated activin A levels in cord blood postnatally compared with preterms without these complications.…”

Section: Activin a In Perinatal Brain Injurymentioning

confidence: 99%

“…44 However, others could not reproduce this association. 43 Timing of the insult, extent of injury, and postinjury interval might be a possible explanation of these discrepancies.…”

Section: Activin a In Perinatal Brain Injurymentioning

confidence: 99%

Activin A in Perinatal Brain Injury

2015

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Activin A is a multifunctional growth and differentiation factor belonging to the transforming growth factor β (TGF-β) family. Growing evidence indicates its role as a neurotrophic factor and regulator of synaptic transmission as well as its functional importance in several types of cerebral injury. We recently described age-dependent expression of activin A and its regulation at the mRNA and protein level under different conditions of global hypoxia in the neonatal mouse brain. This review discusses the current knowledge of the function and regulation of activin A from human studies as well as from experimental models of brain injury focusing on acquired lesions of the developing rodent brain during the early stages of brain maturation.

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Umbilical activin A concentration as an early marker of perinatal hypoxia

Abstract: Umbilical artery activin A combined with other markers of hypoxia could be a useful marker of perinatal hypoxia. Concentration of activin A is significantly higher in male newborns. The mode and time of delivery have no influence on activin A concentration.

Cited by 7 publications

References 27 publications

Early predictors of perinatal brain damage: the role of neurobiomarkers

Early predictors of perinatal brain damage: the role of neurobiomarkers

Activin-A exerts a crucial anti-inflammatory role in neonatal infections

Activin A in Perinatal Brain Injury

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