Umbilical artery hemodynamic features in diabetic and healthy pregnant women

Ermakova, L. B.; Lysenko, S. N.; Чечнева, М. А.; Petrukhin, V. A.; Burumkulova, F. F.

doi:10.17116/rosakush201616454-60

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Следует отметить, что при оценке темпов роста плода у матерей с мутацией в гене GCK необходимо учитывать показатели допплерометрии (объемный кровоток в артерии пуповины, отражающий перфузию между плацентой и плодом), так как причиной формирования маловесного плода может быть не только наличие мутации, но и ФПН или присоединение преэклампсии. При ФПН, как основной причине патологической маловесности плода, определяющим фактором является снижение объемного кровотока в артерии пуповины [42]. диться начиная с момента постановки диагноза и до родоразрешения.…”

Section: Discussionunclassified

Ultrasonic predictors of macrosomia in gestational diabetes mellitus

Lysenko¹,

Чечнева²,

Burumkulova³

et al. 2019

Diabetes mellitus

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BACKGROUND: The basis of early ultrasound (US) diagnosis of diabetic fetopathy (DF) in pregnant with gestational diabetes mellitus (GDM) is the forehanded detection of macrosomia, especially its asymmetric forms. In pregnant with GDM on a diet therapy, the detection of macrosomia may be an indication for starting the insulin therapy. In pregnant with hyperglycemia due to mutation in the glucokinase gene (GCK), US fetal growth dynamics helps to assume the fetal genotype, as well as to stratify the risks of insulin therapy. AIM: To determine the prognostic significance of asymmetric form of macrosomia and the value of the coefficients of proportionality for the diagnosis of DF in pregnant with GDM, including hyperglycemia due to mutation in the GCK gene. MATERIALS AND METHODS: US fetometry was performed in 95 pregnant with GDM (including 22 pregnant with hyperglycemia caused by mutation in the GCK gene) (main group) and 427 healthy pregnant women (control group). Estimated fetal weight, standard fetometric indicators and coefficients of proportionality were evaluated. Retrospective analysis of US predictors of macrosomia was carried out after evaluating the weight of the newborn and clarifying the signs of DF. RESULTS: In the group with GDM, 51 (53.7%) pregnant had children with phenotypic symptoms of DF, including macrosomia 66,7% (34 children). We found statistically significant differences in fetal weight between the control group and the main group who gave birth to children with DF starting from 32 weeks. The coefficients of proportionality (femur length/abdominal circumference and the head circumference/abdominal circumference), characterizing the formation of the asymmetric macrosomia were significantly from 34 weeks (Р0,05). CONCLUSION: The most effective predictive fetometric indicators for the diagnosis of fetal macrosomia are the dimensions of fetal abdomen and fetal weight 90 percentile for gestational age. A specific sign of DF in pregnant with GDM is the asymmetric macrosomia. In pregnant with a mutation in the GCK gene, the tendency to macrosomia was revealed only in the absence of a mutation in the fetus, but insulin therapy in the presence of a similar mutation in fetus did not lead to a significant decrease in its percentile ranges.

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Section: Discussionunclassified

Ultrasonic predictors of macrosomia in gestational diabetes mellitus

Lysenko¹,

Чечнева²,

Burumkulova³

et al. 2019

Diabetes mellitus

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“…Помимо макросомии, дети рождаются с диспластическим ожирением, имеют фенотипические особенности: лунообразное лицо, короткая шея, заплывшие глаза, гипертрихоз, пастозность, отеки на ногах и пояснице, непропорционально выраженный плечевой пояс, длинное туловище, короткие конечности, что входит в понятие диабетической фетопатии (ДФ). Клинически последняя проявляет себя кардиомиопатией, гепато-и спленомегалией [8,9,10].…”

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Nutritional status of children born to mothers with gestational diabetes mellitus

Богомаз

Папышева

Шурыгина

et al. 2021

jour

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Objective: to optimize the diagnosis of nutritional status disorders in children born at different gestational periods from mothers with diabetes mellitus by assessing their nutritional status to predict the development of morphofunctional changes in different periods of childhoodMaterials and methods: 84 children from mothers with gestational diabetes mellitus, born in the maternity hospital of the Bauman State Clinical Hospital. The assessment of children’s physical development was carried out in accordance with WHO Anthro standards (2006). A comparative analysis of the variables of children in different groups was carried out using the Student’s T-test. “Statistica 10 programm” was used.Results: preterm children by the age of 3 are not only aligned with full-term children in terms of nutritional status, but also begin to exceed the latter in terms of body weight and length. In further age periods, their indicators do not go beyond the population. In full-term children from 4 years of age, there is a tendency to overweight and obesity.Conclusion: the nutritional status and physical development of children born to mothers with gestational diabetes mellitus depends on the gestational age and undergoes dramatic changes in different age periods of childhood.

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Umbilical artery hemodynamic features in diabetic and healthy pregnant women

Cited by 2 publications

References 6 publications

Ultrasonic predictors of macrosomia in gestational diabetes mellitus

Ultrasonic predictors of macrosomia in gestational diabetes mellitus

Nutritional status of children born to mothers with gestational diabetes mellitus

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