Umbilical cord blood application analysis of Guangdong Cord Blood Bank

Shi, Cong-Ying; Wei, Wei; Lyu, Lijuan; Wang, Qi

doi:10.1097/cm9.0000000000000924

Cited by 4 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All UCB samples were prepared in accordance with the requirements of relevant Chinese laws and regulations. [9] Trained nurses, obstetricians, and midwives collected the UCB samples from mothers who provided informed consent. All participants tested negative for hepatitis B surface antigen, hepatitis C antibody, syphilis antibody, and acquired immune deficiency syndrome (AIDS) antibody, and none had thalassemia and G-6-phosphate glucose dehydrogenase deficiency.…”

Section: Methodsmentioning

confidence: 99%

“…[7] The ease of collection, immunological naivety, physical storage, [8] and potential as a new source of hematopoietic stem cell transplantation are the advantages of UCB. [9] In an extensive clinical application and in-depth study of UCB by researchers, it was reported that cord blood is not only used to treat blood system diseases but also widely used to treat various immune deficiencies, metabolic diseases, and neurological diseases and used in regenerative medicine. [10] At the UCB public bank, cord blood is available for patients in need of hematopoietic stem cell transplantation nationwide.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of cord blood double collection method on cord blood hematopoietic stem cell transplantation-related indices and blood gas analysis

Shi,

Rao,

Huang

et al. 2023

Medicine

Self Cite

View full text Add to dashboard Cite

Background: Umbilical cord blood has been widely used in clinical transplantation. Blood gas analysis of umbilical cord blood is routinely used to evaluate neonatal asphyxia. This study aimed to evaluate an improved umbilical cord blood collection method that does not affect the results of umbilical cord blood gas analysis and hematopoietic stem cell transplantation-related indices. Methods: Three hundred pregnant women were recruited between December 2019 and August 2022. In total, 270 umbilical cord blood samples were included and randomly divided into 3 groups. Group A was defined as the group in which both umbilical cord blood samples for hematopoietic stem cell transplantation and blood gas analysis were collected. Group B was defined as the group from which umbilical cord blood was collected for hematopoietic stem cell transplantation. Group C was defined as that wherein umbilical cord blood was collected only for blood gas analysis. Hematopoietic stem cell transplantation-related indices were detected in groups A and B, and blood gas analysis was performed in groups A and C. Results: Hematopoietic stem cell transplantation-related indices were not significantly different between groups A and B. The pH, base excess, and lactic acid values were not significantly different between groups A and C. Conclusion: The cord blood double collection method would not affect the results of umbilical cord blood gas analysis and hematopoietic stem cell transplantation-related indices. It is suitable for cord blood collection when preparing for hematopoietic stem cell transplantation and blood gas analysis.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of cord blood double collection method on cord blood hematopoietic stem cell transplantation-related indices and blood gas analysis

Shi,

Rao,

Huang

et al. 2023

Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cord blood is a rich source of hematopoietic stem cells widely used to treat blood-borne diseases, including blood cancers, leukemia, thalassemia, congenital anemia, and some defective immune system diseases [ 1 ]. Cord blood is the blood remaining in the umbilical cord and placenta after birth and is often discarded, but it is rich in stem cells [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Ethical challenges of cord blood banks: a scoping review

et al. 2022

View full text Add to dashboard Cite

Cord blood is a rich source of hematopoietic stem cells used to treat many diseases of blood origin. Thus, storage banks were created to store and provide umbilical cord cells. With the development of diagnostic and therapeutic technologies and techniques in medicine, ethical issues have also become more widespread and complex. After the creation of the cord blood banks, efforts were made to address the ethical issues associated with such banks. The present study attempts to identify the ethical challenges in these banks in the published studies. Databases including PubMed, Scopus, Web of Science (WOS), Embase, Proquest, and Google Scholar were searched from January 1996 to January 2021. Then, the ethical challenges of the cord blood bank were extracted from the results section using thematic content analysis. 22 studies were selected based on inclusion and exclusion criteria. The ethical challenges raised in the studies included private or public ownership of the bank, fair access to banking services, informed and voluntary consent, failure to provide sufficient information to individuals about the process, confidentiality of user's information, conflict of interest of bank founders (who are commonly doctors). The findings of this study indicated that there are serious ethical concerns regarding umbilical cord blood banks. Responding clearly to these ethical challenges calls for the attention of policymakers and medical ethics professionals; this will require a clear statement of the various aspects of these banks for society.

show abstract