Unbalanced translocation (1; 7) and inversion 16 in a patient with acute myelocytic leukemia

Tasaka, Taizo; Nagai, Masami; Bando, Syuji; Sayo, Yoshitaka; Murata, Michio; Sasaki, Kazunori; Ikeda, Kazuma; Takahara, Jiro

doi:10.1016/0145-2126(93)90077-x

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2002

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“…Despite the presence of inv(16), eosinophilia was not observed throughout the clinical course of our patient. As we previously reported, patients with inv(16) might not always present with eosinophilia [14], especially when this appears in the presence of other chromosome aberrations. Furthermore, the absence of abnormal eosinophilia might be related to refractoriness to chemotherapy.…”

Section: Discussionmentioning

confidence: 75%

Marked Thrombocytosis Following Relapse of Acute Myeloblastic Leukemia Associated with Development of Translocation (2;14) (p13;q32)

Tasaka

Nagai

Matsuhashi

et al. 2002

Leukemia & Lymphoma

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Thrombocytosis is a rare finding in acute myeloblastic leukemia (AML). Here, we describe a patient with AML who relapsed with marked thrombocytosis. The patient was initially diagnosed as having AML (M4) with a low platelet count. The patient was started on combination chemotherapy including high-dose etoposide and achieved complete remission. However, the patient relapsed six months later with an extremely high platelet count (72.5 x 10(4)/microl). Cytogenetic analysis at relapse revealed the development of t(2;14)(p13;q32). Despite the repeated combination chemotherapy, the patient died with progressive disease. This case suggests that the additional chromosomal aberration t(2;14)(p13;q32) may be related to abnormal thrombocytosis in AML.

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Section: Discussionmentioning

confidence: 75%