In this paper, we aim to replace in the definitions of covariance and correlation the usual trace Tr by a tracial positive map between unital C * -algebras and to replace the functions x α and x 1−α by functions f and g satisfying some mild conditions. These allow us to define the generalized covariance, the generalized variance, the generalized correlation and the generalized Wigner-Yanase-Dyson skew information related to the tracial positive maps and functions f and g. We present a generalization of Heisenberg's uncertainty relation in the noncommutative framework. We extend some inequalities and properties for the generalized correlation and the generalized Wigner-Yanase-Dyson skew information. Furthermore, we extend some inequalities for the generalized skew information such as uncertainty relation and the relation between the generalized variance and the generalized skew information.2010 Mathematics Subject Classification. Primary 46L05, 47A63; Secondary 81P15.