Uncommon glial tumors

Chen, Thomas C.; Elder, J. Bradley; González-Gómez, Ignacio; McComb, J. Gordon

doi:10.1016/b978-0-443-06967-3.00026-0

Cited by 4 publications

(5 citation statements)

References 330 publications

(306 reference statements)

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“…6 This single-center experience supports the notion that a substantial portion of pediatric GGs demonstrate an atypical imaging appearance and clinical presentation. These tumors are associated with a less favorable clinical course.…”

Section: Discussionsupporting

confidence: 64%

Atypical pediatric ganglioglioma is common and associated with a less favorable clinical course

Patibandla¹,

Ridder²,

Dorris³

et al. 2016

Journal of Neurosurgery: Pediatrics

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OBJECT Ganglioglioma (GG) is commonly recognized as a low-grade tumor located in the temporal lobe, often presenting with seizures. Most are amenable to complete resection and are associated with excellent oncological outcome. The authors encountered several GGs in various locations, which seem to have a less favorable clinical course than GGs in the temporal lobe. METHODS The authors performed a single-center retrospective review of all children with a histological diagnosis of GG who were treated at Children’s Hospital Colorado between 1997 and 2013. Each tumor was categorized by 2 pediatric neuroradiologists as typical or atypical based on preoperative MRI appearance. Typical lesions were cortically based, within a single cerebral lobe, well-circumscribed, and solid or mixed solid/cystic. The treatment and clinical course of each patient was analyzed. RESULTS Thirty-seven children were identified, with a median age at presentation of 8.2 years and median follow-up of 38.0 months. Eighteen tumors (48.6%) were typical and 19 (51.4%) were atypical. All typical lesions presented with seizures, whereas no atypical lesions did so. Sixteen (88.9%) typical lesions were located in the temporal lobe. In the atypical group, tumor location was variable, including 11 (57.9%) in the brainstem. Death during follow-up was statistically more common in the atypical group (31.6% vs 0%, p = 0.02). Gross-total resection (GTR) was achieved for 15 of 16 typical tumors (93.8%), compared with 3 atypical tumors (15.8%, p < 0.0001). Presentation with seizure or non-brainstem location were each associated with survival (p = 0.02 and 0.004, respectively). The presence of mutation in BRAF exon 15 did not differ between the 2 groups. CONCLUSIONS Pediatric GG with typical imaging features is associated with excellent rates of GTR and overall survival. Atypical GG is commonly encountered, less amenable to GTR, and associated with a worse outcome. This may relate to anatomical or biological characteristics and merits further investigation.

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Section: Discussionsupporting

confidence: 64%

Atypical pediatric ganglioglioma is common and associated with a less favorable clinical course

Patibandla¹,

Ridder²,

Dorris³

et al. 2016

Journal of Neurosurgery: Pediatrics

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“…Hypothalamic hamartomas are non-neoplastic, heterotopic nodules, resembling the normal gray matter of the hypothalamus. [ 10 ] HHs occurs due to tissue displacement during the fifth or sixth week of gestation, when the ventral aspect of the neuraxis approaches the anterior tip of the end of the notochord. HH is associated with endocrinological, neurological symptoms, and symptoms due to the accompanying anomaly.…”

Section: Discussionmentioning

confidence: 99%

Central precocious puberty due to hypothalamic hamartoma in a six-month-old infant girl

Kotwal

Yanamandra

Menon

et al. 2012

Indian J Endocr Metab

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Precocious puberty defined as an onset of puberty below eight years in girls and nine years in boys, has an incidence of approximately 1 / 5,000 – 1 / 10,000 subjects with a female / male ratio of 20: 1. It is etiologically classified broadly as central and peripheral. We present to you a case of isosexual (central), precocious puberty in a 16-month-old girl, who was symptomatic since the age of six months, and was later, diagnosed to have hypothalamic hamartoma. It is one of the earliest case records ever in the medical literature of menarche, at an extremely early age (six-month-old child) secondary to a central cause.

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“…Our patient was middle-aged, which is rather uncommon for this type of tumour, occurring typically in younger patients [19][20][21]. During the surgery we noticed the sessile form of a lesion that was non-pedunculated and of a broad base, joined to the ventral part of the hypothalamus [22].…”

Section: Discussionmentioning

confidence: 99%

Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment

Majchrzak

Bierzyńska-Macyszyn

Bobek-Billewicz

et al. 2010

Neurologia i Neurochirurgia Polska

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The bifrontal basal interhemispheric trans-lamina terminalis approach allows for radical resection of primary tumours of the hypothalamus while avoiding serious post-operative deficits. This approach enabled the preservation of the olfactory bulb and tract and prevented damage of the frontal lobes. The use of DTI helped to establish the location and borders of the lamina terminalis, to establish the posterior surface of the optic chiasm and the optic tracts, and to save the anterior and lateral wall of the hypothalamus.

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Uncommon glial tumors

Cited by 4 publications

References 330 publications

Atypical pediatric ganglioglioma is common and associated with a less favorable clinical course

Atypical pediatric ganglioglioma is common and associated with a less favorable clinical course

Central precocious puberty due to hypothalamic hamartoma in a six-month-old infant girl

Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment

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