Under-response correction for EBT3 films in the presence of proton spread out Bragg peaks

Fiorini, F.; Kirby, D.; Thompson, James; Green, S.; Parker, D.J.; Jones, Bleddyn; Hill, Mark A.

doi:10.1016/j.ejmp.2013.12.006

Cited by 45 publications

(67 citation statements)

References 18 publications

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“…The GAFCHROMIC (Ashland Inc., Cincinnati, OH, USA) EBT, EBT2 and EBT3 radiochromic film models, are widely used for particle beams commissioning and QA procedures . On the other hand it is non‐negligible the decrease in response due to the high specific ionization of ions at Bragg peak …”

Section: Detectors For Absorbed Dose In Nonreference Conditionsmentioning

confidence: 99%

Dose detectors, sensors, and their applications

Giordanengo

2018

Medical Physics

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This article is intended to present the different types of particle and radiation detectors available for applications in particle therapy. Several types of detectors and sensors exist for measurements of absorbed dose in reference and nonreference conditions and the ones in use for beam monitoring. Therefore, this manuscript focuses on the following applications: (a) primary methods for dosimetry in ion beams, (b) measurements of absorbed dose in realistic patient‐specific scenarios with different dose delivery configurations, and (c) beam monitoring. Water and graphite calorimeters, Faraday cups, ionization based gas detectors are described first, followed by the description of the protocols for proton and ion dosimetry. Then films, scintillator and solid‐state detectors are reviewed. Finally, several types of ionization chambers (large, pinpoint, arrays of chambers arranged in regular 1D or 2D pattern, parallel‐plate configuration with large integral electrodes or with anode segmented in strips or pixels, multi‐wire, and the multi‐gap prototype) have been considered. New beam monitors to deal with a wide range of intensity and pulsed beams expected from new accelerators, different dose fractionation and advanced delivery techniques are presented. The existing detectors available for particle therapy have been described taking into account the different requirements for devices used in reference and nonreference conditions and the ones designed for beam monitoring.

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Section: Detectors For Absorbed Dose In Nonreference Conditionsmentioning

confidence: 99%

Dose detectors, sensors, and their applications

Giordanengo

2018

Medical Physics

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“…The problem lies in the fact that the correction procedure is not simple. Various methods have been suggested and investigated to make a proper correction of the dose profiles measured with EBT2 and EBT3 Gafchromic films (Park et al, 2011;Carnicer et al, 2013;Fiorini et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Measurements of 2D distributions of absorbed dose in protontherapy with Gafchromic EBT3 films

Gambarini

Regazzoni

Artuso

et al. 2015

Applied Radiation and Isotopes

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“…Figure compares the Bragg peaks generated with Geant 4, Pstar , and the PSD function to the experimental data described in Section 2.B The corresponding χ 2 / ndf and P ‐values are presented in Table . The experimental data, Pstar and the PSD function are in good agreement for 29.06 [Fig.…”

Section: Resultsmentioning

confidence: 94%

Analytical dose modeling for preclinical proton irradiation of millimetric targets

et al. 2017

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Purpose: Due to the considerable development of proton radiotherapy, several proton platforms have emerged to irradiate small animals in order to study the biological effectiveness of proton radiation. A dedicated analytical treatment planning tool was developed in this study to accurately calculate the delivered dose given the specific constraints imposed by the small dimensions of the irradiated areas. Methods: The treatment planning system (TPS) developed in this study is based on an analytical formulation of the Bragg peak and uses experimental range values of protons. The method was validated after comparison with experimental data from the literature and then compared to Monte Carlo simulations conducted using GEANT4. Three examples of treatment planning, performed with phantoms made of water targets and bone-slab insert, were generated with the analytical formulation and GEANT4. Each treatment planning was evaluated using dose-volume histograms and gamma index maps. Results: We demonstrate the value of the analytical function for mouse irradiation, which requires a targeting accuracy of 0.1 mm. Using the appropriate database, the analytical modeling limits the errors caused by misestimating the stopping power. For example, 99% of a 1-mm tumor irradiated with a 24-MeV beam receives the prescribed dose. The analytical dose deviations from the prescribed dose remain within the dose tolerances stated by report 62 of the International Commission on Radiation Units and Measurements for all tested configurations. In addition, the gamma index maps show that the highly constrained targeting accuracy of 0.1 mm for mouse irradiation leads to a significant disagreement between GEANT4 and the reference. This simulated treatment planning is nevertheless compatible with a targeting accuracy exceeding 0.2 mm, corresponding to rat and rabbit irradiations. Conclusion: Good dose accuracy for millimetric tumors is achieved with the analytical calculation used in this work. These volume sizes are typical in mouse models for radiation studies. Our results demonstrate that the choice of analytical rather than simulated treatment planning depends on the animal model under consideration.

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Under-response correction for EBT3 films in the presence of proton spread out Bragg peaks

Cited by 45 publications

References 18 publications

Dose detectors, sensors, and their applications

Dose detectors, sensors, and their applications

Measurements of 2D distributions of absorbed dose in protontherapy with Gafchromic EBT3 films

Analytical dose modeling for preclinical proton irradiation of millimetric targets

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