2023
DOI: 10.20944/preprints202308.1688.v1
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Understanding Cancer from an Evolutionary Perspective; DSCD Cells as Cell-of-Origin in Non-Mutational Sporadic Cancers

Vladimir F. Niculescu

Abstract: The life cycle of cancer follows the life cycle of the common ancestor of amoebozoans, metazoans, and fungi (AMF) and its systemic germline, which serves as a blueprint for all germlines capable of asymmetric cell division (ACD) and stem cell differentiation. Consequently, the oxygen sensitivity of the ancient non-gametogenic germline (Urgermline) was inherited by all germ and stem cell lines including the cancer germline. They all respond to Ugermline’s hyperoxia with loss of stemness and ACD ability and a dy… Show more

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Cited by 2 publications
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“…In contrast, ECCB demonstrates that the cell-of-origin for cancer is a defective, functionally impaired cell of adult stem cell origin. This cell type is characterized by severe DNA damage, loss of stemness and differentiation potential, and the capacity for asymmetric cell divisions [1][2][3][4]. From an evolutionary perspective, precancerous cells are more likely to be perceived as defective phenotypes that need repair.…”
mentioning
confidence: 99%
“…In contrast, ECCB demonstrates that the cell-of-origin for cancer is a defective, functionally impaired cell of adult stem cell origin. This cell type is characterized by severe DNA damage, loss of stemness and differentiation potential, and the capacity for asymmetric cell divisions [1][2][3][4]. From an evolutionary perspective, precancerous cells are more likely to be perceived as defective phenotypes that need repair.…”
mentioning
confidence: 99%