Understanding desiccation patterns of blood sessile drops

Chen, Ruoyang; Zhang, Liyuan; Zang, Duyang; Shen, Wei

doi:10.1039/c7tb02290e

Cited by 31 publications

(28 citation statements)

References 26 publications

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“…Recently, we found that, after evaporation, polytetrafluoroethylene (PTFE) colloidal droplets can form radial cracks, owing to the formation of a similarly shaped stress field within droplets during evaporation process, which has been confirmed via formed radial 2 Advances in Condensed Matter Physics wrinkles during evaporation (confirmed by the formation of radial wrinkles) [16]. Moreover, evaporation of biological drops, such as blood, often leads to interesting crack patterns which contain valuable information for diagnosis [18].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Coffee-Ring Effect via Substrate Roughness in Evaporation of Colloidal Droplets

Zhang

Chen

Liu

et al. 2018

Advances in Condensed Matter Physics

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The analysis of dried drop patterns has various applications in research fields like archeology, medical practice, printing, and so on. In this paper, we studied the evaporation and pattern formation of polytetrafluoroethylene (PTFE) colloid droplets on smooth substrate and rough substrates with different roughness. We found that the evaporation of droplets shows remarkable coffee-ring effect on smooth substrate and that the cross-section of the ring is wedge-shaped with its thickness decreasing from the edge to the center. However, with increasing roughness, the effect strengthened, with the section of the coffee-ring changing from wedge- to hill-shaped. The contact angle decreased with increasing roughness, leading to an increase in evaporation rate. Moreover, wicking led to additional evaporation, which also enhanced capillary flow, moving more particles to the edge. In addition, the rough structure of the substrate inhibited the back-flow of the capillary flow, preventing the particles’ move to the center. The formation of radial wrinkles on the edge also led to particle retention, preventing them from moving to the center. All these factors contribute to the decreased width and increased height of the coffee-ring pattern after evaporation on rough surfaces. It is an effective method to regulate the deposition pattern of evaporating droplet by changing the substrate roughness.

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Section: Introductionmentioning

confidence: 99%

Enhanced Coffee-Ring Effect via Substrate Roughness in Evaporation of Colloidal Droplets

Zhang

Chen

Liu

et al. 2018

Advances in Condensed Matter Physics

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“…The dried drop patterns of blood serum were also suggested to be useful for disease diagnosis because some featured morphologies of blood serum patterns could be used to acquire information about the health state of human organisms [138]. However, the use of whole blood patterns for medical diagnosis was rarely reported [42,153], and more systematic experiments are expected.…”

Section: Biomedical Applicationmentioning

confidence: 99%

Droplet Drying Patterns on Solid Substrates: From Hydrophilic to Superhydrophobic Contact to Levitating Drops

Tarafdar

Tarasevich

Choudhury

et al. 2018

Advances in Condensed Matter Physics

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This review is devoted to the simple process of drying a multicomponent droplet of a complex fluid which may contain salt or other inclusions. These processes provide a fascinating subject for study. The explanation of the rich variety of patterns formed is not only an academic challenge but also a problem of practical importance, as applications are growing in medical diagnosis and improvement of coating/printing technology. The fundamental scientific problem is the study of the mechanism of microand nanoparticle self-organization in open systems. The specific fundamental problems to be solved, related to this system, are the investigation of the mass transfer processes, the formation and evolution of phase fronts, and the identification of mechanisms of pattern formation. The drops of liquid containing dissolved substances and suspended particles are assumed to be drying on a horizontal solid insoluble smooth substrate. The chemical composition and macroscopic properties of the complex fluid, the concentration and nature of the salt, the surface energy of the substrate, and the interaction between the fluid and substrate which determines the wetting all affect the final morphology of the dried film. The range of our study encompasses the fully wetting case with zero contact angle between the fluid and substrate to the case where the drop is levitated in space, so there is no contact with a substrate and angle of contact can be considered as 180 ∘ .

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“…Regarding the study of fracture occurrence in drying droplets, the investigation of biological fluids has recently attracted an increasing interest because of possible biomedical, forensic, archaeological and industrial applications. For example, the observation of the final crack pattern in dried droplets of biological fluids (saliva, urine, plasma) [15][16][17] and suspensions (blood) [18][19][20][21] has been used to detect pathological states and develop innovative diagnostic methodologies. The study of the evaporation of biological suspensions represents a scientific challenge due to the high complexity of the system, which is essentially composed by deformable objects (cells) dispersed in an aqueous fluid rich in proteins and salts.…”

Section: Introductionmentioning

confidence: 99%

The solute mechanical properties impact on the drying of dairy and model colloidal systems

et al. 2019

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Understanding desiccation patterns of blood sessile drops

Abstract: Formation mechanisms of cracking patterns in different regions of a desiccation blood sessile drop.

Cited by 31 publications

References 26 publications

Enhanced Coffee-Ring Effect via Substrate Roughness in Evaporation of Colloidal Droplets

Enhanced Coffee-Ring Effect via Substrate Roughness in Evaporation of Colloidal Droplets

Droplet Drying Patterns on Solid Substrates: From Hydrophilic to Superhydrophobic Contact to Levitating Drops

The solute mechanical properties impact on the drying of dairy and model colloidal systems

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