The utilization of blockchain technology (BT) has arisen as a viable remedy for tackling crucial challenges in financial system (bitcoin) and the healthcare sector, including data security, interoperability, and transparency. The integration of BT in the healthcare industry has significant promise, but it is a complex process that is impacted by several variables. This systematic review seeks to provide a thorough comprehension of the models, obstacles, and forthcoming research pertaining to the use of BT in the healthcare sector. The paper examines the fundamental ideas and models that are crucial in comprehending the implementation of BT in the healthcare sector. The theories encompassed in this list are the Technology Acceptance Model (TAM), Innovation Diffusion Theory, Trust and Transparency Theories. These theories together provide a systematic framework for evaluating the process of adoption. The systematic review results provide an overview of the present state of blockchain implementation in the healthcare sector. The challenges that have been highlighted include obstacles related to regulations, difficulties in achieving interoperability, concerns over data privacy, and the need for a strong and reliable infrastructure. Furthermore, the advantages of using BT, including heightened data protection and increased healthcare services.